S,S'-(1,3-phenylenebis(1,2-ethanediyl))bisisothiourea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: S,S'-(1,3-phenylenebis(1,2-ethanediyl))bisisothiourea
• 英文别名: phenylene-1,3-bis(ethane-2-isothiourea)；1,3-bis-(2-carbamimidoylmercapto-ethyl)-benzene；1.3-Bis-(2-guanylmercapto-aethyl)-benzol；1,3-Bis-(2-carbamimidoylmercapto-aethyl)-benzol；2-{2-[3-(2-Carbamimidoylsulfanyl-ethyl)-phenyl]-ethyl}-isothiourea；2-[3-(2-carbamimidoylsulfanylethyl)phenyl]ethyl carbamimidothioate
• 化学式: C₁₂H₁₈N₄S₂
• 分子量: 282.434
• InChiKey: YEUSLPIIQGZHQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  150
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,3-双(2-氨基乙基)苯 在 乙醇 、 氢溴酸 、 溶剂黄146 、 sodium nitrite 作用下， 生成 S,S'-(1,3-phenylenebis(1,2-ethanediyl))bisisothiourea
  参考文献：
  名称：

  Über间苯撑-β，β-二萘啶溴; 贝特拉格·祖尔·德萨米尼隆·阿利帕蒂谢尔·二胺。（56. MitteilungüberStickstoff-Heterocyclen）

  摘要：

  DOI：

  10.1002/hlca.660280197

文献信息

• AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS
  申请人：LICHTER Jay

  公开号：US20090306225A1

  公开（公告）日：2009-12-10

  Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

  本文公开了使用免疫调节剂和耳压调节剂治疗耳部疾病的组合物和方法。在这些方法中，通过将免疫调节剂和/或耳压调节剂组合物和配方直接应用于耳媒介和/或耳内靶区，或通过灌注进入耳媒介和/或耳内结构，局部给患有耳部疾病的个体进行治疗。
• Auris Formulations for Treating Otic Diseases and Conditions
  申请人：Otonomy, Inc.

  公开号：US20160228357A1

  公开（公告）日：2016-08-11

  Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

  本文介绍了使用免疫调节剂和耳压调节剂治疗耳部疾病的组合物和方法。在这些方法中，通过直接将免疫调节剂和/或耳压调节剂组合物和配方局部应用于患有耳部疾病的个体的耳媒体和/或耳内靶区，或通过灌注到耳媒体和/或耳内结构中。
• AGENT FOR REGENERATION AND/OR PROTECTION OF NERVES
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1886693A1

  公开（公告）日：2008-02-13

  An EP2 agonist which may have an EP3 agonistic effect has an effect of regenerating and/or protecting nerves, and is therefore useful as a therapeutic agent for a disease of the peripheral nervous system, such as a lower or upper motor neuron disease, a nerve root disease, plexopathy, thoracic outlet compression syndrome, peripheral neuropathy, neurofibromatosis and neuromuscular transmission disease. An EP2 agonist which has an EP3 agonistic effect is a safe and effective agent for the regeneration and/or protection of nerves which has little influence on the circulatory system.

  可能具有 EP3 激动效应的 EP2 激动剂具有再生和/或保护神经的作用，因此可用作外周神经系统疾病的治疗剂，例如下运动神经元或上运动神经元疾病、神经根疾病、神经丛病、胸廓出口压迫综合征、外周神经病、神经纤维瘤病和神经肌肉传导疾病。具有 EP3 激动效应的 EP2 激动剂是一种安全有效的神经再生和/或保护剂，对循环系统的影响很小。
• Agent for regeneration and/or protection of nerves
  申请人：Ono Pharmaceutical Co., Ltd.

  公开号：EP2308510A1

  公开（公告）日：2011-04-13

  An EP2 agonist which may have an EP3 agonistic effect has an effect of regenerating and/or protecting nerves, and is therefore useful as a therapeutic agent for a disease of the peripheral nervous system, such as a lower or upper motor neuron disease, a nerve root disease, plexopathy, thoracic outlet compression syndrome, peripheral neuropathy, neurofibromatosis and neuromuscular transmission disease. An EP2 agonist which has an EP3 agonistic effect is a safe and effective agent for the regeneration and/or protection of nerves which has little influence on the circulatory system.

  可能具有 EP3 激动效应的 EP2 激动剂具有再生和/或保护神经的作用，因此可用作外周神经系统疾病的治疗剂，例如下运动神经元或上运动神经元疾病、神经根疾病、神经丛病、胸廓出口压迫综合征、外周神经病、神经纤维瘤病和神经肌肉传导疾病。具有 EP3 激动效应的 EP2 激动剂是一种安全有效的神经再生和/或保护剂，对循环系统的影响很小。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。