2-ethyl-2-hydroxy-succinic acid | 1944-62-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-ethyl-2-hydroxy-succinic acid
• 英文别名: β-Oxy-butan-α.β-dicarbonsaeure；α-Oxy-α-aethyl-bernsteinsaeure；3-Methylsaeure-pentanol-(3)-saeure-(1)；2-Aethyl-2-hydroxy-bernsteinsaeure；α-Aethyl-aepfelsaeure；α-ethylmalic acid；2-Hydroxy-2-ethylsuccinic acid；2-ethyl-2-hydroxybutanedioic acid
• CAS: 1944-62-3
• 化学式: C₆H₁₀O₅
• 分子量: 162.142
• InChiKey: YVYGHRNLPUMVBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium carbonate 作用下， 生成 2-ethyl-2-hydroxy-succinic acid 、 2-乙基丙烯酸
  参考文献：
  名称：

  Ssemenow, Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1899, vol. 31, p. 286

  摘要：

  DOI：

文献信息

• [EN] PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS, THEIR PREPARATION AND USE AS SIGMA LIGANDS<br/>[FR] COMPOSÉS DE PYRAZOLO[3,4-D]PYRIMIDINE, LEUR PRÉPARATION ET UTILISATION EN TANT QUE LIGANDS SIGMA
  申请人：ESTEVE LABOR DR

  公开号：WO2013010950A1

  公开（公告）日：2013-01-24

  The present invention relates to new pyrazolo[3,4-d]pyrimidine compounds having a great affinity for sigma receptors, especially sigma-1 receptors as well as to the process for the preparation thereof, to composition comprising them and to their use as medicaments.

  本发明涉及具有对σ受体，特别是σ-1受体具有很强亲和力的新吡唑[3,4-d]嘧啶化合物，以及其制备过程、包含它们的组合物和作为药物的用途。
• BIOFUEL PRODUCTION BY RECOMBINANT MICROORGANISMS
  申请人：Liao James C.

  公开号：US20090081746A1

  公开（公告）日：2009-03-26

  Provided herein are metabolically-modified microorganisms useful for producing biofuels. More specifically, provided herein are methods of producing high alcohols including isobutanol, 1-butanol, 1-propanol, 2-methyl-1-butanol, 3-methyl-1-butanol and 2-phenylethanol from a suitable substrate.

  本文提供了用于生产生物燃料的代谢修饰微生物。更具体地，本文提供了从适当底物中生产高醇类化合物的方法，包括异丁醇、1-丁醇、1-丙醇、2-甲基-1-丁醇、3-甲基-1-丁醇和2-苯乙醇。
• Process for preparation of 1-(2s,3s)-2-benzhydryl-n-(5- tert-butyl-2-methoxybenzyl)quinuclidin-3-amine
  申请人：Basford Patricia A.

  公开号：US20090099364A1

  公开（公告）日：2009-04-16

  This invention relates to an improved process for the preparation of (2S,3S)-2-benzhydryl-N-(5-tent-butyl-2-methoxybenzyl)quinuclidin-3-amine, (hereinafter “compound of Formula I”) and its pharmaceutically acceptable salts. In particular, the invention is directed to an improved synthesis of the monohydrate citrate salt of the compound of Formula (Ia).

  本发明涉及一种改进的制备(2S,3S)-2-苯甲基-N-(5-叔丁基-2-甲氧基苯基)喹诺啉-3-胺(以下简称"公式I化合物")及其药学上可接受的盐的方法。特别地，本发明涉及一种改进的合成公式(Ia)化合物的单水合柠檬酸盐的方法。
• DESIGNER CALVIN-CYCLE-CHANNELED PRODUCTION OF BUTANOL AND RELATED HIGHER ALCOHOLS
  申请人：Lee James Weifu

  公开号：US20110177571A1

  公开（公告）日：2011-07-21

  Designer Calvin-cycle-channeled and photosynthetic NADPH-enhanced pathways, the associated designer genes and designer transgenic photosynthetic organisms for photobiological production of butanol and related higher alcohols from carbon dioxide and water are provided. The butanol and related higher alcohols include 1-butanol, 2-methyl-1-butanol, isobutanol, 3-methyl-1-butanol, 1-hexanol, 1-octanol, 1-pentanol, 1-heptanol, 3-methyl-1-pentanol, 4-methyl-1-hexanol, 5-methyl-1-heptanol, 4-methyl-1-pentanol, 5-methyl-1-hexanol, and 6-methyl-1-heptanol. The designer photosynthetic organisms such as designer transgenic oxyphotobacteria and algae comprise designer Calvin-cycle-channeled and photosynthetic NADPH-enhanced pathway gene(s) and biosafety-guarding technology for enhanced photobiological production of butanol and related higher alcohols from carbon dioxide and water.

  本发明提供了设计师卡尔文循环通道和光合作用NADPH增强途径、相关设计师基因和转基因光合生产丁醇和相关高级醇的生物体，这些生物体利用二氧化碳和水进行光生物生产。所述丁醇和相关高级醇包括1-丁醇、2-甲基-1-丁醇、异丁醇、3-甲基-1-丁醇、1-己醇、1-辛醇、1-戊醇、1-庚醇、3-甲基-1-戊醇、4-甲基-1-己醇、5-甲基-1-庚醇、4-甲基-1-戊醇、5-甲基-1-己醇和6-甲基-1-庚醇。设计师光合生产丁醇和相关高级醇的生物体，例如设计师转基因氧光合细菌和藻类，包括设计师卡尔文循环通道和光合作用NADPH增强途径基因和生物安全防护技术，以增强从二氧化碳和水中光生物生产丁醇和相关高级醇的产量。
• SHIP INHIBITORS AND USES THEREOF
  申请人：Kerr William G.

  公开号：US20130102577A1

  公开（公告）日：2013-04-25

  The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject; (ii) a method of inhibiting a SHIP1 protein in a cell; (iii) a method of selectively inhibiting a SHIP1 protein in a cell; (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant; (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2; (vi) a method of ex vivo or in vitro treatment of transplants; (vii) a method of inhibiting tumor growth and metastasis in a subject; (viii) a method of treating a hematologic malignancy in a subject; (ix) a method of inducing apoptosis of multiple myeloma cells; (x) a method of treating multiple myeloma in a subject; (xi) a method of inhibiting the proliferation of a human breast cancer cell; and (xii) a method of treating breast cancer in a subject.

  本发明涉及SHIP抑制剂化合物及使用这些化合物的方法。具体而言，本发明揭示了以下方法：（i）治疗移植物抗宿主病的方法；（ii）抑制细胞中SHIP1蛋白的方法；（iii）选择性抑制细胞中SHIP1蛋白的方法；（iv）治疗或预防器官或组织移植接受者的移植物抗宿主病（GVHD）的方法；（v）调节表达SHIP1或SHIP2的细胞中SHIP活性的方法；（vi）移植物的离体或体外治疗方法；（vii）抑制主体中肿瘤生长和转移的方法；（viii）治疗主体的血液恶性肿瘤的方法；（ix）诱导多发性骨髓瘤细胞凋亡的方法；（x）治疗主体的多发性骨髓瘤的方法；（xi）抑制人乳腺癌细胞增殖的方法；（xii）治疗主体的乳腺癌的方法。