[2-(2,6-Dimethoxy-4-prop-2-enylphenoxy)-1-(3,4,5-trimethoxyphenyl)propyl] acetate | 1345412-95-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [2-(2,6-Dimethoxy-4-prop-2-enylphenoxy)-1-(3,4,5-trimethoxyphenyl)propyl] acetate
• CAS: 1345412-95-4
• 化学式: C₂₅H₃₂O₈
• 分子量: 460.5
• InChiKey: ZFRZPRJLJSQUNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  33
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  81.7
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  [2-(2,6-Dimethoxy-4-prop-2-enylphenoxy)-1-(3,4,5-trimethoxyphenyl)propyl] acetate 在 甲醇 、 sodium methylate 作用下， 以99%的产率得到erythro-Δ^8'-7-hydroxy-3,4,5,3',5'-pentaamethoxy-8-O-4'-neolignan
  参考文献：
  名称：

  A new shortcut synthesis route for (±)raphidecursinol

  摘要：

  The new shortcut synthesis route of (+/-)raphidecursinol 1, a racemic 8,4'-oxyneolignan compound, can be more easily achieved by the synthesis route, starting front readily available inexpensive 3,4,5-trimethoxybenzaldehyde and 1,2,3-trihydroxybenzene. All structures were confirmed by (1)H NMR, IR and MS. (C) 2009 Yong Wu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2009.10.027
• 作为产物：
  描述：

  4-烯丙基-2,6-二甲氧基苯酚 、 [2-methylsulfonyloxy-1-(3,4,5-trimethoxyphenyl)propyl] acetate 在 18-冠醚-6 、 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 120.0 ℃ 、200.0 kPa 条件下， 反应 0.17h， 以72%的产率得到[2-(2,6-Dimethoxy-4-prop-2-enylphenoxy)-1-(3,4,5-trimethoxyphenyl)propyl] acetate
  参考文献：
  名称：

  A new shortcut synthesis route for (±)raphidecursinol

  摘要：

  The new shortcut synthesis route of (+/-)raphidecursinol 1, a racemic 8,4'-oxyneolignan compound, can be more easily achieved by the synthesis route, starting front readily available inexpensive 3,4,5-trimethoxybenzaldehyde and 1,2,3-trihydroxybenzene. All structures were confirmed by (1)H NMR, IR and MS. (C) 2009 Yong Wu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2009.10.027

文献信息

• A new shortcut synthesis route for (±)raphidecursinol
  作者：Hua Jie Yuan、Yao Yao Cheng、Shan Qian、Xiang Xiao、Yong Wu

  DOI：10.1016/j.cclet.2009.10.027

  日期：2010.2

  The new shortcut synthesis route of (+/-)raphidecursinol 1, a racemic 8,4'-oxyneolignan compound, can be more easily achieved by the synthesis route, starting front readily available inexpensive 3,4,5-trimethoxybenzaldehyde and 1,2,3-trihydroxybenzene. All structures were confirmed by (1)H NMR, IR and MS. (C) 2009 Yong Wu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.