(E)-3-(t-butyldimethylsilyl)-2-propen-1-ol-methanesulfonate | 154673-62-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: (E)-3-(t-butyldimethylsilyl)-2-propen-1-ol-methanesulfonate
• 英文别名: [(E)-3-[tert-butyl(dimethyl)silyl]prop-2-enyl] methanesulfonate
• CAS: 154673-62-8
• 化学式: C₁₀H₂₂O₃SSi
• 分子量: 250.434
• InChiKey: ONRYTUNGHUUTQN-VQHVLOKHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.57
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-脱氧野尻霉素 、 (E)-3-(t-butyldimethylsilyl)-2-propen-1-ol-methanesulfonate 在 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 1,5-Dideoxy-1,5-{[(E)-3-(t-butyldimethylsilyl)-2-propenyl]imino}-d-glucitol
  参考文献：
  名称：

  New deoxynojirimycin derivatives as potent inhibitors of intestinal α-glucohydrolases

  摘要：

  New N-alkyl, alkenyl and benzyl substituted DNJ derivatives incorporating a silicon atom in the substituent were synthesised. Kinetic parameters (K-i, t(1/2)) for inhibition of rat intestinal alpha-glucohydrolases as well as human lysosomal alpha-glucosidases were measured. New DNJ derivatives are potent and selective inhibitors of intestinal alpha-glucohydrolases. (C) 1997, Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00012-7
• 作为产物：
  描述：

  叔丁基二甲基氯硅烷 在 甲醇 、 正丁基锂 、 stannyl ether 、 三乙胺 、 红铝 作用下， 以 二氯甲烷 为溶剂， 生成 (E)-3-(t-butyldimethylsilyl)-2-propen-1-ol-methanesulfonate
  参考文献：
  名称：

  New deoxynojirimycin derivatives as potent inhibitors of intestinal α-glucohydrolases

  摘要：

  New N-alkyl, alkenyl and benzyl substituted DNJ derivatives incorporating a silicon atom in the substituent were synthesised. Kinetic parameters (K-i, t(1/2)) for inhibition of rat intestinal alpha-glucohydrolases as well as human lysosomal alpha-glucosidases were measured. New DNJ derivatives are potent and selective inhibitors of intestinal alpha-glucohydrolases. (C) 1997, Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00012-7

文献信息

• New deoxynojirimycin derivatives as potent inhibitors of intestinal α-glucohydrolases
  作者：Brigitte Lesur、Jean-Bernard Ducep、Marie-Noelle Lalloz、Anne Ehrhard、Charles Danzin

  DOI：10.1016/s0960-894x(97)00012-7

  日期：1997.2

  New N-alkyl, alkenyl and benzyl substituted DNJ derivatives incorporating a silicon atom in the substituent were synthesised. Kinetic parameters (K-i, t(1/2)) for inhibition of rat intestinal alpha-glucohydrolases as well as human lysosomal alpha-glucosidases were measured. New DNJ derivatives are potent and selective inhibitors of intestinal alpha-glucohydrolases. (C) 1997, Elsevier Science Ltd.