N-benzyl-L-cysteine | 65776-14-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-benzyl-L-cysteine
• 英文别名: aktive β-Mercapto-α-benzylamino-propionsaeure；N-Benzyl-L-cystein；(R)-2-benzylamino-3-mercapto-propionic acid；(2R)-2-(benzylamino)-3-sulfanylpropanoic acid
• CAS: 65776-14-9
• 化学式: C₁₀H₁₃NO₂S
• 分子量: 211.285
• InChiKey: UAYNVVPNQUUEEZ-VIFPVBQESA-N

物化性质

• 沸点：
  350.9±37.0 °C(Predicted)
• 密度：
  1.220±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  50.3
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-benzyl-L-cysteine 在 sodium hydroxide 、 乙酰氯 作用下， 以 乙醇 为溶剂， 反应 33.0h， 生成 3-benzyl-4-methoxycarbonyl-1,3-thiazolidine-2-thione
  参考文献：
  名称：

  Ghiaci; Tabrizi, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1998, vol. 37, # 1, p. 10 - 14

  摘要：

  DOI：
• 作为产物：
  描述：

  (R)-2-Benzylamino-3-((R)-2-benzylamino-2-carboxy-ethyldisulfanyl)-propionic acid 在 盐酸 、 锌 作用下， 以 甲醇 为溶剂， 反应 0.75h， 以96%的产率得到N-benzyl-L-cysteine
  参考文献：
  名称：

  Ghiaci; Tabrizi, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1998, vol. 37, # 1, p. 10 - 14

  摘要：

  DOI：

文献信息

• [EN] COMPOUNDS<br/>[FR] COMPOSÉS
  申请人：M3 BIOTECHNOLOGY INC

  公开号：WO2017210489A1

  公开（公告）日：2017-12-07

  The present technology relates to compounds, kits, compositions, and methods useful for the treatment of numerous pathologies including dementia, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and other neurodegenerative diseases, spinal cord injury, traumatic brain injury, diabetes and metabolic syndrome, defective wound healing, and/or sensorineural hearing and vision loss.

  当前技术涉及化合物、试剂盒、组合物以及用于治疗多种病理状况的方法，包括痴呆症、阿尔茨海默病、帕金森病、肌萎缩侧索硬化症以及其他神经退行性疾病，脊髓损伤、创伤性脑损伤、糖尿病和代谢综合征、伤口愈合缺陷以及/或感音神经性听力和视力损失。
• Alpha-helical mimetics
  申请人：Lessene Guillaume Laurent

  公开号：US20080153802A1

  公开（公告）日：2008-06-26

  Benzoyl urea derivatives that are alpha helical peptides mimetics that mimic BH3-only proteins, compositions containing them, their conjugation to cell-targeting-moieties, and their use in the regulation of cell death are disclosed. The benzoyl urea derivatives are capable of binding to and neutralizing pro-survival Bcl-2 proteins. Use of benzoyl urea derivatives in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also described.

  公开了模拟α螺旋肽的苯甲酰脲衍生物，这些衍生物模拟BH3-仅蛋白，含有它们的组合物，它们与细胞靶向基团的结合，以及它们在调节细胞死亡中的用途。苯甲酰脲衍生物能够结合并中和促生存的Bcl-2蛋白。还描述了在治疗和/或预防与细胞死亡失调相关的疾病或症状中使用苯甲酰脲衍生物。
• Lipid probes and uses thereof
  申请人：THE SCRIPPS RESEARCH INSTITUTE

  公开号：US10168342B2

  公开（公告）日：2019-01-01

  Disclosed herein are methods, compositions, probes, assays and kits for identifying a lipid binding protein as a drug binding target. Also disclosed herein are methods, compositions, and probes for mapping a ligand binding site on a lipid binding protein, identification of lipid binding proteins, generating drug-lipid binding protein profiles, high throughput drug screening, and identification of drugs as potential lipid binding protein ligands.

  披露了用于识别脂质结合蛋白作为药物结合靶点的方法、组合物、探针、检测和试剂盒。此外，还披露了用于绘制脂质结合蛋白上的配体结合位点、识别脂质结合蛋白、生成药物-脂质结合蛋白轮廓、高通量药物筛选以及识别作为潜在脂质结合蛋白配体的药物的方法、组合物和探针。
• [EN] COMPOSITIONS USEFUL IN THERAPY OF AUTOPHAGY-RELATED PATHOLOGIES, AND METHODS OF MAKING AND USING THE SAME<br/>[FR] COMPOSITIONS UTILES EN THÉRAPIE DE PATHOLOGIES LIÉES À L'AUTOPHAGIE, ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：UNIV TOLEDO

  公开号：WO2017147440A1

  公开（公告）日：2017-08-31

  Lanthionine ketimine derivatives, and methods of making and using the same, are described. Included are lanthionine ketimine phosphonate (LK-P), lanthionine ketimine ester phosphonate (LKE-P) derivatives, as well as lanthionine ketimine derivatives having a tert-enamide moiety at the 2-position (NVP-LKE).

  兰硫氨酸酮亚胺衍生物的制备方法和用途被描述。包括兰硫氨酸酮亚胺磷酸酯（LK-P）、兰硫氨酸酮亚胺酯磷酸酯（LKE-P）衍生物，以及在2位点具有叔-烯酰胺基团的兰硫氨酸酮亚胺衍生物（NVP-LKE）。
• [EN] FLUORINATED 4' ALKYLUMBELLIFERYL α-D-GLUCOPYRANOSIDES, BIOLOGICAL STERILIZATION INDICATORS INCLUDING THE SAME AND METHODS OF USING THE SAME<br/>[FR] 4' ALKYLUMBELLIFERYL α-D-GLUCOPYRANOSIDES FLUORÉS, INDICATEUR DE STÉRILISATION BIOLOGIQUE LES COMPRENANT ET PROCÉDÉS D'UTILISATION ASSOCIÉS
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2020115661A1

  公开（公告）日：2020-06-11

  A self-contained biological sterilization indicator comprises: a housing; bacterial spores comprising, and/or capable of producing, an enzyme capable of catalyzing cleavage of an enzyme substrate; and a frangible container containing a composition, wherein the composition comprises the enzyme substrate, wherein if the frangible container is broken the composition will contact the bacterial spores to form a mixture having an initial pH in the range from 6.0 to 9.0. The enzyme substrate comprises a fluorinated 4'-alkylumbelliferyl α-D-glucopyranoside represented by the structural formula (I) wherein one of R1 and R2 is F and the other is H, and R3 is an alkyl group having from 1 to 12 carbon atoms. A biological sterilization indicator comprising a kit containing isolated components comprising (i) bacterial spores comprising, and/or capable of producing, an enzyme capable of catalyzing cleavage of the enzyme substrate and a method of assessing efficacy of a sterilization process are also disclosed.

  一个独立的生物灭菌指示器包括：一个外壳；包含细菌孢子的、和/或能够产生能催化酶底物裂解的酶的细菌孢子；以及一个易碎容器，其中容器内含有一种组合物，该组合物包括酶底物，如果易碎容器破裂，组合物将接触到细菌孢子以形成具有初始pH在6.0至9.0范围内的混合物。酶底物包括一种由结构式(I)表示的氟代的4'-烷基炔香豆蔻基α-D-葡萄糖吡喃苷，其中R1和R2中的一个是F，另一个是H，R3是具有1至12个碳原子的烷基。还公开了一种包含孤立组分的套件的生物灭菌指示器，其中组分包括（i）包含细菌孢子的、和/或能够产生能催化酶底物裂解的酶的细菌孢子，以及一种评估灭菌过程有效性的方法。