N-chloroacetyl-DL-tyrosine | 23965-60-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-chloroacetyl-DL-tyrosine
• 英文别名: N-chloroacetyl-tyrosine；N-Chloracetyl-DL-tyrosin；N-Chloracetyl-tyrosin；N-Chloracetyl-dl-tyrosin；n-(Chloroacetyl)tyrosine；2-[(2-chloroacetyl)amino]-3-(4-hydroxyphenyl)propanoic acid
• CAS: 23965-60-8
• 化学式: C₁₁H₁₂ClNO₄
• 分子量: 257.674
• InChiKey: GDOGSOZOUAVIFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-chloroacetyl-DL-tyrosine 、 氨 生成 甘氨酰-L-酪氨酸
  参考文献：
  名称：

  Fischer,E., Chemische Berichte, 1904, vol. 37, p. 2490

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 作用下， 生成 N-chloroacetyl-DL-tyrosine
  参考文献：
  名称：

  Fischer,E., Chemische Berichte, 1904, vol. 37, p. 2490

  摘要：

  DOI：

文献信息

• Modified gangliosides and the functional derivatives thereof
  申请人：FIDIA S.p.A.

  公开号：EP0433112A1

  公开（公告）日：1991-06-19

  N-acyl-N,N′-di-lysogangliosides, N′-acyl-N,N′-di-­lysogangliosides and N,N′-diacyl-N,N′-di-­lysogangliosides, in which the acyl groups are derived from an organic acid of the aliphatic, aromatic, araliphatic, alicyclic or heterocyclic series and in which at least one of the two acyl groups is not aliphatic, and their preparation are disclosed. Also disclosed is the preparation of the esters, inner esters, amides and hydroxy peracylates of these compounds and salts thereof. These compounds are useful in the treatment of pathologies of the central and peripheral nervous systems.

  N-acyl-N,N′-di-lysogangliosides, N′-acyl-N,N′-di-lysogangliosides和N,N′-diacyl-N,N′-di-lysogangliosides，其中酰基来自脂肪族、芳香族、脂环族、脂环族或杂环族的有机酸，并且其中至少有一个酰基不是脂肪族、本发明公开了两个酰基中至少有一个不是脂肪族的二乙酰基-N，N′-二赖糖糖苷及其制备方法。此外，还公开了这些化合物的酯、内酯、酰胺和羟基过酰基化合物及其盐的制备方法。这些化合物可用于治疗中枢和外周神经系统的疾病。
• SUPER VERSATILE METHOD FOR PRESENTING CYCLIC PEPTIDE ON PROTEIN STRUCTURE
  申请人：The University Of Tokyo

  公开号：EP3666897A1

  公开（公告）日：2020-06-17

  The present invention provides a method of presenting a cyclic peptide on a protein having a loop structure. The cyclic peptide has a chemically crosslinked structure for forming an intramolecular cyclic structure. The method includes replacing the chemically crosslinked structure of the cyclic peptide with two amino acid residues constituting the loop structure, thereby fusing the cyclic peptide with the protein having a loop structure.

  本发明提供了一种在具有环状结构的蛋白质上呈现环肽的方法。环肽具有化学交联结构，可形成分子内环结构。该方法包括用构成环状结构的两个氨基酸残基取代环肽的化学交联结构，从而将环肽与具有环状结构的蛋白质融合在一起。
• MODIFICATION OF D AND T ARMS OF TRNA ENHANCING D-AMINO ACID AND BETA-AMINO ACID UPTAKE
  申请人：The University Of Tokyo

  公开号：EP3699276A1

  公开（公告）日：2020-08-26

  The purpose of the present invention is to provide, for translation in a cell-free translation system, a novel translation system capable of synthesizing a peptide having therein consecutive non-proteinogenic amino acids. The present invention provides a tRNA containing the base sequence represented by SEQ ID NO: 1 and encoding a non-proteinogenic amino acid.

  本发明的目的是为在无细胞翻译系统中的翻译提供一种新型翻译系统，该系统能够合成具有连续非蛋白源氨基酸的多肽。本发明提供了一种含有 SEQ ID NO: 1 所代表的碱基序列并编码非蛋白源氨基酸的 tRNA。
• NTCP INHIBITOR
  申请人：The University of Tokyo

  公开号：EP3738603A1

  公开（公告）日：2020-11-18

  The present invention provides a sodium taurocholate cotransporting polypeptide (NTCP) inhibitor comprising a cyclic peptide having a Xw1-W-Xw2-W structure, wherein Xw1 and Xw2 are each independently T, S, I, L, or V, or a N-alkylamino acid thereof, or having a P-Xp1-Xp2-H structure, wherein Xp1 is any amino acid, and Xp2 is I, L, or V, or a N-alkylamino acid thereof, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种牛磺胆酸钠共转运多肽（NTCP）抑制剂，该抑制剂包含具有 Xw1-W-Xw2-W 结构的环肽，其中 Xw1 和 Xw2 各自独立地为 T、S、I、或具有 P-Xp1-Xp2-H 结构，其中 Xp1 是任何氨基酸，Xp2 是 I、L 或 V，或其 N-烷基氨基酸，或其药学上可接受的盐。
• SUPER VERSATILE METHOD FOR IMPARTING NEW BINDING SPECIFICITY TO ANTIBODY
  申请人：The University of Tokyo

  公开号：EP3831846A1

  公开（公告）日：2021-06-09

  The purpose of the present invention is to provide an efficient and versatile method for granting an additional binding activity to an antibody by inserting a peptide sequence into the antibody. The present invention provides a method of granting a binding ability to a second target molecule to an antibody, comprising inserting an internal peptide sequence of a cyclic peptide into an Fc region of the antibody, wherein the cyclic peptide has the binding ability to the second target molecule different from a first target molecule to be recognized by the antibody.

  本发明的目的是提供一种高效、通用的方法，通过在抗体中插入多肽序列，赋予抗体额外的结合活性。本发明提供了一种赋予抗体与第二靶分子结合能力的方法，包括将环肽的内部肽序列插入抗体的 Fc 区，其中环肽与第二靶分子的结合能力不同于抗体识别的第一靶分子。