4-(4-methoxyphenyl)-but-2-en-1-ol | 42238-19-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(4-methoxyphenyl)-but-2-en-1-ol
• 英文别名: 4-(4-methoxyphenyl)but-2-en-1-ol
• CAS: 42238-19-7
• 化学式: C₁₁H₁₄O₂
• 分子量: 178.231
• InChiKey: CKSVZVKDDKRBBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(4-methoxyphenyl)-but-2-en-1-ol 、 三氯乙腈 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 二氯甲烷 为溶剂， 以98%的产率得到(E)-4-(4-methoxyphenyl)but-2-enyl 2,2,2-trichloroacetimidate
  参考文献：
  名称：

  Asymmetric Synthesis of Unsaturated Monocyclic and Bicyclic Nitrogen Heterocycles

  摘要：

  Hydrolysis of scalemic trichloroacetamides Cl3CCONHCH(R)CHCH2 and allylation, or acylation with but-3-enoic acid, followed by ring-closing metathesis resulted in the formation of unsaturated pyrrolidine and piperidine building blocks. These were employed in the synthesis of (S)-coniine (R = Pr) and a formal synthesis of (+)-anisomycin (R = p-MeOC5H4). Extension of this methodology with R = CH2CHCH2 employing two ring-closing metatheses resulted in the synthesis of unsaturated quinolizidinone and indolizidinone frameworks.

  DOI：

  10.1021/ol900880w
• 作为产物：
  描述：

  甲氧苯胺 、 1,3-丁二烯 生成 4-(4-methoxyphenyl)-but-2-en-1-ol
  参考文献：
  名称：

  Ganushchak,N.I. et al., Journal of Organic Chemistry USSR (English Translation), 1973, vol. 9, p. 1030 - 1032

  摘要：

  DOI：

文献信息

• Asymmetric Synthesis of Unsaturated Monocyclic and Bicyclic Nitrogen Heterocycles
  作者：Hiroshi Nomura、Christopher J. Richards

  DOI：10.1021/ol900880w

  日期：2009.7.2

  Hydrolysis of scalemic trichloroacetamides Cl3CCONHCH(R)CHCH2 and allylation, or acylation with but-3-enoic acid, followed by ring-closing metathesis resulted in the formation of unsaturated pyrrolidine and piperidine building blocks. These were employed in the synthesis of (S)-coniine (R = Pr) and a formal synthesis of (+)-anisomycin (R = p-MeOC5H4). Extension of this methodology with R = CH2CHCH2 employing two ring-closing metatheses resulted in the synthesis of unsaturated quinolizidinone and indolizidinone frameworks.
• Ganushchak,N.I. et al., Journal of Organic Chemistry USSR (English Translation), 1973, vol. 9, p. 1030 - 1032
  作者：Ganushchak,N.I. et al.

  DOI：——

  日期：——