O,O-Diethyl-O-(2,5-dichlor-4-bromphenyl)-phosphat | 4855-63-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: O,O-Diethyl-O-(2,5-dichlor-4-bromphenyl)-phosphat
• 英文别名: 4-Bromo-2,5-dichlorophenyl diethyl phosphate；(4-bromo-2,5-dichlorophenyl) diethyl phosphate
• CAS: 4855-63-4
• 化学式: C₁₀H₁₂BrCl₂O₄P
• 分子量: 377.987
• InChiKey: PVCKTKKWMRHDFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  乙基溴硫磷 在 二甲基二环氧乙烷 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 0.08h， 生成 O,O-Diethyl-O-(2,5-dichlor-4-bromphenyl)-phosphat
  参考文献：
  名称：

  Dimethyldioxirane conversion of phosphine sulfides and phosphorothioates into their corresponding oxygen analogues

  摘要：

  DOI：

  10.1016/s0040-4039(00)89065-6

文献信息

• Dimethyldioxirane conversion of phosphine sulfides and phosphorothioates into their corresponding oxygen analogues
  作者：Francisco Sánchez-Baeza、Gaël Durand、Damiá Barceló、Angel Messeguer

  DOI：10.1016/s0040-4039(00)89065-6

  日期：1990.1
• SANCHEZ-BAEZA, FRANCISCO;DURAND, GAEL;BARCELO, DAMIA;MESSEGUER, ANGEL, TETRAHEDRON LETT., 31,(1990) N3, C. 3359-3362
  作者：SANCHEZ-BAEZA, FRANCISCO、DURAND, GAEL、BARCELO, DAMIA、MESSEGUER, ANGEL

  DOI：——

  日期：——
• Oxidation of organophosphorus pesticides for the sensitive detection by a cholinesterase-based biosensor
  作者：Hye-Sung Lee、Young Ah Kim、Young Ae Cho、Yong Tae Lee

  DOI：10.1016/s0045-6535(01)00005-4

  日期：2002.1

  A potentiometric flow injection-type biosensor developed in our laboratory was used for the determination of organophosphorus pesticides (OPs). The principle of the biosensor is that the degree of inhibition of a sensor enzyme by an OP is dependent on the concentration of the pesticide. The sensor system consisted of a reactor with acetylcholinesterase (AChE) immobilized on a controlled pore glass and a detector with a tubular H+-selective membrane electrode. In order to examine the possibility of enhancing the sensitivity of the sensor by converting OPs to oxidized forms (stronger inhibitors), a comparison of the degree of enzyme inhibition by OPs at 10(-6) M before and after their oxidation was made. All of the ten pesticides tested exhibited greater inhibitory power toward the sensor enzyme following oxidation. All of the oxidized pesticides at 10(-6) M inhibited the sensor enzyme to a considerable degree, demonstrating the utility of the developed method for the class-specific determination of OPs. A calibration curve for diazinon, over the concentration range of 10(-11)-10(-4) M, was obtained. The lower detection limit was 2 x 10(-10) M. Treatment of the inhibited enzyme with pyridine-2-aldoxime restored the enzyme to near full activity, allowing repeated use of the sensor. (C) 2002 Published by Elsevier Science Ltd.