2-hydroxyethylammonium lactate | 68815-69-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 2-hydroxyethylammonium lactate
• 英文别名: ethanolamine lactate；2-Hydroxy ethylammonium lactate；2-hydroxyethylazanium;2-hydroxypropanoate
• CAS: 68815-69-0
• 化学式: C₂H₇NO*C₃H₆O₃
• 分子量: 151.163
• InChiKey: NEQXUPRFDXNNTA-UHFFFAOYSA-N

物化性质

• 熔点：
  -58.6 °C (decomp)
• 密度：
  1.21020 g/cm3(Temp: 25.00 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.61
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  乳酸 、 C.I.酸性橙108 以 乙醇 为溶剂， 反应 20.0h， 生成 2-hydroxyethylammonium lactate
  参考文献：
  名称：

  离子液体乙醇胺乳酸盐从煤焦油中分离甲酚的提取及机理探索

  摘要：

  从煤焦油中分离甲酚对化学工业具有重要意义。在这项工作中，高效率的和绿色的羟基铵离子液体乙醇胺乳酸（[HMEA] L）涂布作为萃取剂提取三个不同的甲酚（邻- ，间- ，和对-从低温煤焦油甲酚） 。离子液体[HMEA] L由乙醇胺和乳酸合成，并经1 H NMR，TGA和FT-IR表征。确定提取效率和分配系数以评估[HMEA] L的提取性能。结果表明，[HMEA] L画面高提取效率和分配系数，用于分离p-来自模型油的甲酚。此外，分子动力学（MD）模拟已被用于探索从模型油中提取甲酚的机理。从MD模拟结果计算出相互作用能，径向和空间分布函数以及自扩散系数，并通过FT-IR进一步探索了萃取机理。可以得出结论，阳离子和阴离子都对萃取起作用。但是，阴离子在从模型油中提取甲酚时显示出更重要的作用。最后，在这项工作中探讨了[HMEA] L的回收和再利用。

  DOI：

  10.1016/j.molliq.2020.112845

文献信息

• Thermophysical Properties of Protic Ionic Liquids Monoethanolamine, Diethanolamine, and Triethanolamine Lactate in Water
  作者：Hemayat Shekaari、Mohammed Taghi Zafarani-Moattar、Saeid Faraji

  DOI：10.1021/acs.jced.0c00831

  日期：2021.5.13

  behavior of the mentioned ionic liquids in water bulk by using apparent molar isobaric expansions Eφ0 and . The viscosity measurements were used to determine the viscosity B-coefficient. Finally, the solute–solvent interactions were explained with the obtained results. The results suggest that ionic liquid [2-HTEA]La has a stronger interaction with water compared to other ionic liquids.

  在不同的过程中，必须具备应用质子链烷醇胺离子液体的绝对知识以及对这些材料的多种热物理性质的理解。在这方面，离子液体（ILs），乳酸2-羟乙基铵[2-HEA] La，乳酸双（2-羟乙基）铵[2-HDEA]的水溶液的密度，声速，粘度和折射率数据在87.1 kPa压力下，在T = 288.15–318.125 K的ILs稀浓度区域中，测定了La和三（2-羟乙基）乳酸铵[2-HTEA] La 。标准偏摩尔体积和偏摩尔熵压缩（V φ 0和Κ φ 0）由Redlich-Mayer方程的参数确定。此外，皮兹相互作用理论被用于实验值的相关性。标准偏摩尔体积的温度依赖性涂敷了用于确定所述结构制造，或通过使用表观摩尔等压膨胀打破水散装所提到的离子液体的行为Ë φ 0和。粘度测量用于确定粘度B系数。最后，用所获得的结果解释了溶质与溶剂之间的相互作用。结果表明，与其他离子液体相比，离子液体[2-HTEA] La与水的相互作用更强。
• Compositions and method for promoting the growth of human hair
  申请人：——

  公开号：US20040247554A1

  公开（公告）日：2004-12-09

  Provided are compositions comprising monoethanolamine salts of thioglycolic, salicylic, lactic and glycolic acids in combination with an organic enzyme, preferably papain, and an oxidizing aged their methods of use to induce hair growth in the scalp of humans and other mammals.

  提供的是由巯基乙醇胺盐、水杨酸、乳酸和乙醇酸单乙醇胺盐组成的混合物，与有机酶（最好是木瓜蛋白酶）以及一种氧化剂一起使用的方法，用于促进人类和其他哺乳动物头皮上的毛发生长。
• Repurposing cycloaddition of β-carbonyl phosphonate and azide to synthesize triazolyl phosphonates <i>via</i> ionic-liquid-based data-driven screening
  作者：Anlian Zhu、Dongshuang Fan、Yanbo You、Honglei Wang、Yang Zhao、Jianji Wang、Lingjun Li

  DOI：10.1039/d2gc02461f

  日期：——

  liquids for discovering new reactivity, developing potent synthetic reactions, and even simplifying bioactivity evaluations. Using ILDDS, we repurposed the cycloaddition of β-carbonyl phosphonate and azide to synthesize triazolyl phosphonates that usually produced phosphonate-leaving products under the traditional conditions. And then, the repurposed cycloaddition reaction allows the access of triazolyl

  膦酸是一类广泛存在于天然产物和人工合成的功能分子中的重要结构单元。Nature 使用 β-羰基膦酸作为通用结构单元来获取结构多样的膦酸衍生物，这为化学家提供了一种仿生方法，但是，它受到化学反应过程中 C-P 键断裂的不利趋势的限制。为了应对这一挑战，我们在此开发了一种基于离子液体的数据驱动筛选 (ILDDS)，该方法可以综合利用离子液体的多功能效应来发现新的反应性、开发有效的合成反应，甚至简化生物活性评估。使用 ILDDS，我们重新利用 β-羰基膦酸酯和叠氮化物的环加成来合成三唑基膦酸酯，在传统条件下通常会产生膦酸酯离去产物。然后，重新利用的环加成反应允许在温和条件下使用带有各种取代基的三唑基膦酸酯。此外，一个集成的工作流程结合了模块化和组合合成、简单的纯化和原位生物活性评估可以从头设计并以高通量方式实施，最终导致快速获得膦酸盐化合物以抑制立枯丝核菌的生长。
• An Efficient Catalytic System Based on CuI and Ionic Liquid for the Synthesis of Propargylamines Through One-Pot A3 Coupling Reactions
  作者：Anlian Zhu、Jingyi Wang、Mingyue Wang、Dongshuang Fan、Lingjun Li

  DOI：10.1007/s10562-022-04109-w

  日期：——

  mild reaction conditions and simple operation procedures, no volatile organic solvents and other additives were involved, and no inert gas protection were needed. In addition, the ionic liquid utilized in this work was easy to be prepared and its utilization made the catalytic system recyclable. All of these superiorities made this catalytic system efficient and eco-friendly for the synthesis of propargylamines

  合成了一系列离子液体，并研究了它们对 Cu 催化的一锅法 A 3偶联反应合成炔丙胺的协同作用。结果表明，基于离子液体[MEA][H 2 PO 4的复合催化体系]和CuI对目标炔丙胺具有优异的催化活性和选择性，一系列具有吸电和给电基团的芳香醛和杂芳醛均能达到良好至优异的分离产率。该催化体系反应条件温和，操作程序简单，不涉及挥发性有机溶剂和其他添加剂，也不需要惰性气体保护。此外，该工作中使用的离子液体易于制备，其利用使催化体系可回收。所有这些优势使得该催化体系高效且环保地用于炔丙胺的合成。 图形概要
• Hydroxyl alkyl ammonium ionic liquid assisted green and one-pot regioselective access to functionalized pyrazolodihydropyridine core and their pharmacological evaluation
  作者：Divyang M. Patel、Mayank G. Sharma、Ruturajsinh M. Vala、Irene Lagunes、Adrián Puerta、José M. Padrón、Dhanji P. Rajani、Hitendra M. Patel

  DOI：10.1016/j.bioorg.2019.01.029

  日期：2019.5

  Herein our team explored a promising synthetic trail to Functionalized pyrazolodihydropyridine core using hydroxyl alkyl ammonium ionic liquid via one-pot fusion of 3-methyl-1-phenyl-1H-pyrazole-5-amine, different heterocyclic aldehydes and 1, 3-Cyclic diones. The aimed compounds were obtained by Domino-Knoevenagel condensation and Michael addition followed by cyclization. The reaction transformation involves the formation of two CeC and one CeN bond formation. The perspective of the present work is selectively approached to Functionalized pyrazolodihydropyridine core excluding other potential parallel reactions under environmentally benign reaction condition. The present protocol show features such as the low E-factor, ambiphilic behavior of ionic liquid during reaction transformation, scale-up to a multigram scale, reusability of the ionic liquid, mild reaction condition, and produce water as a byproduct. All newly derived compounds were evaluated for their in vitro biological activities. In preliminary biological studies compound, 4c showed better potency than the standard drug ampicillin against Gram-negative bacteria (E. coli); the compound 4i exhibited outstanding activity against S. aeruginosa which is far better than ampicillin, chloramphenicol, and ciprofloxacin. The compound 4m was found more potent against C. albicans, than that of griseofulvin and show equipotency to nystatin whereas, in preliminary antitubercular screening, compound 4o was exhibited more potency than rifampicin. Noteworthy compounds 4f and 4i were found most active in antiproliferative screening.