6-(Pentan-3-yl)pyridin-2-amine | 89226-80-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-(Pentan-3-yl)pyridin-2-amine
• 英文别名: 6-pentan-3-ylpyridin-2-amine
• CAS: 89226-80-2
• 化学式: C₁₀H₁₆N₂
• 分子量: 164.25
• InChiKey: KOTYIRKFSTXHGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  氨基钠 、 油酸 、 2-(3-乙丙基)嘧啶 、 氢气 在 氮气 作用下， 以 水 、 邻二甲苯 为溶剂， 反应 10.5h， 以to give 258.6 g of 2 -amino-6-(3-pentyl)pyridine的产率得到6-(Pentan-3-yl)pyridin-2-amine
  参考文献：
  名称：

  Chichibabin reaction

  摘要：

  在有机溶剂中通过苏打胺对含氮杂环碱进行Chichibabin胺化反应的改进包括在反应混合物上方的气相中至少施加50 psi的压力，并添加足够的氨到混合物中，使氨在气相中的分压至少达到5 psi。公开了首选的温度和压力范围，以及催化剂和其他实施该反应的首选步骤。取得了显著的结果，包括改善和改变了Chichibabin胺化反应中经典预期的收率，包括至少三种新的物质组成。

  公开号：

  US05003069A1

文献信息

• Modified chichibabin reaction, and novel pyridine derivatives
  申请人：REILLY INDUSTRIES, INC.

  公开号：EP0098684A2

  公开（公告）日：1984-01-18

  In a Chichibabin amination of a nitrogen-containing heterocyclic base by sodamide in an organic solvent, the improvement comprising conducting the reaction under pressure of at least about 50 psi in the gas phase above the reaction mixture and adding ammonia to the mixture sufficient to produce a partial pressure of ammonia of at least about 5 psi in the gas phase. Preferred temperature and pressure ranges are disclosed, as are catalysts and other preferred steps for practicing the reaction. Significant results are obtained including improved and changed yields from those classically expected in Chichibabin aminations, including new composition of matter in at least three cases.

  在有机溶剂中用钠酰胺对含氮杂环基进行秩巴比胺化反应中，改进包括在反应混合物上方气相中至少约 50 psi 的压力下进行反应，并向混合物中加入氨，足以在气相中产生至少约 5 psi 的氨分压。公开了优选的温度和压力范围，以及催化剂和实施反应的其他优选步骤。与传统的 Chichibabin 氨基化反应相比，本发明取得了显著的成果，包括改进和改变了产率，在至少三种情况下获得了新的物质组成。
• 14-MEMBERED KETOLIDES AND METHODS OF THEIR PREPARATION AND USE
  申请人：President and Fellows of Harvard College

  公开号：US20200361980A1

  公开（公告）日：2020-11-19

  Provided herein are methods of preparing new 14-membered ketolides via coupling of an eastern and western half moiety, followed by macrocyclization, and optional functionalization. Intermediates in the synthesis of these ketolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using these ketolides are also provided.
• US5003069A
  申请人：——

  公开号：US5003069A

  公开（公告）日：1991-03-26
• Chichibabin reaction
  申请人：Reilly Industries, Inc.

  公开号：US05003069A1

  公开（公告）日：1991-03-26

  In a Chichibabin amination of a nitrogen-containing heterocyclic base by sodamide in an organic solvent, the improvement comprising conducting the reaction under pressure of at least about 50 psi in the gas phase above the reaction mixture and adding ammonia to the mixture sufficient to produce a partial pressure of ammonia of at least about 5 psi in the gas phase. Preferred temperature and pressure ranges are disclosed, as are catalysts and other preferred steps for practicing the reaction. Significant results are obtained including improved and changed yields from those classically expected in Chichibabin aminations, including new compositions of matter in at least three cases.

  在有机溶剂中通过苏打胺对含氮杂环碱进行Chichibabin胺化反应的改进包括在反应混合物上方的气相中至少施加50 psi的压力，并添加足够的氨到混合物中，使氨在气相中的分压至少达到5 psi。公开了首选的温度和压力范围，以及催化剂和其他实施该反应的首选步骤。取得了显著的结果，包括改善和改变了Chichibabin胺化反应中经典预期的收率，包括至少三种新的物质组成。