(S)-tert-butyl 1-octanoylpyrrolidine-2-carboxylate | 1422144-61-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-tert-butyl 1-octanoylpyrrolidine-2-carboxylate
• 英文别名: tert-butyl (2S)-1-octanoylpyrrolidine-2-carboxylate
• CAS: 1422144-61-3
• 化学式: C₁₇H₃₁NO₃
• 分子量: 297.438
• InChiKey: JKDLDPNYNVLYMD-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  辛酸 、 L-脯氨酸叔丁酯 在 ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以84%的产率得到(S)-tert-butyl 1-octanoylpyrrolidine-2-carboxylate
  参考文献：
  名称：

  XtalFluor-E, an Efficient Coupling Reagent for Amidation of Carboxylic Acids

  摘要：

  Amides were produced from carboxylic acids and amines by using XtalFluor-E as an activator. Even poorly reactive carboxylic acids can be transformed to amides. In addition, optically active amines and/or carboxylic acids were not epimerized/racemized during the process.

  DOI：

  10.1021/ol400045d

文献信息

• XtalFluor-E, an Efficient Coupling Reagent for Amidation of Carboxylic Acids
  作者：Aurélie Orliac、Domingo Gomez Pardo、Agnès Bombrun、Janine Cossy

  DOI：10.1021/ol400045d

  日期：2013.2.15

  Amides were produced from carboxylic acids and amines by using XtalFluor-E as an activator. Even poorly reactive carboxylic acids can be transformed to amides. In addition, optically active amines and/or carboxylic acids were not epimerized/racemized during the process.