selenous acid dimethyl ester | 7600-22-8

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: selenous acid dimethyl ester
• 英文别名: Dimethylselenit；Dimethyl selenite
• CAS: 7600-22-8
• 化学式: C₂H₆O₃Se
• 分子量: 157.028
• InChiKey: NTEFHFJOCXLHIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.31
• 重原子数：
  6
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  selenous acid dimethyl ester 在 氯 作用下， 以 四氯化碳 为溶剂， 生成 dichloro-dimethoxy-λ4-selane
  参考文献：
  名称：

  Mehrotra,R.C.; Mathur,S.N., Indian Journal of Chemistry, 1967, vol. 5, p. 375 - 378

  摘要：

  DOI：
• 作为产物：
  描述：

  甲醇 在 selenium(IV) oxide 作用下， 生成 selenous acid dimethyl ester
  参考文献：
  名称：

  Production and Application of Polyclonal Antibody to Human Thyroid Transcription Factor 2 Reveals Thyroid Transcription Factor 2 Protein Expression in Adult Thyroid and Hair Follicles and Prepubertal Testis

  摘要：

  Germline mutations in thyroid transcription factor 2 (TTF2) cause thyroid agenesis, spiky hair, and cleft palate, indicating thyroidal and extrathyroidal expression. We sought to investigate this by producing and applying an antibody to human TTF2. The coding region of human TTF2 was cloned into a bacterial expression vector, production of the soluble TTF2 protein optimized, and pure TTF2 obtained by nickel chromatography. Rabbits were immunized and the resulting TTF2 polyclonal titrated on formalin-fixed, paraffin-embedded sections of thyroid. The optimized protocol was applied to a range of tissues. Nine milligrams of TTF2 protein was obtained per liter of culture and a high-titer antibody produced. This displayed specific staining of thyroid follicular cell nuclei/cytoplasm and not of the interstitium, connective tissue, smooth muscle, or endothelium. No staining was obtained with the preimmune serum in the same conditions, or with the majority of other tissues tested with the TTF2 polyclonal. The exceptions were testis and skin, in which nuclear TTF2 immunoreactivity was present in the seminiferous tubules and cells in the follicular outer root sheath, respectively. In conclusion, we have produced a polyclonal antibody for human TTF2 and demonstrated immunoreactivity for this transcription factor in adult human thyroid and hair follicles and prepubertal testis.

  DOI：

  10.1089/105072503322511328
• 作为试剂：
  描述：

  Fluorocortexolone acetonide 在 selenous acid dimethyl ester 作用下， 以 乙酸丁酯 为溶剂， 以65.7%的产率得到6α-Fluoro-16α,17α-isopropylidenedihydroxypregna-1,4-diene-21-ol-3,20-dione 21-acetate
  参考文献：
  名称：

  Fluorosteroids VII. Synthesis and biological activity of derivatives of 6α-fluoro-16α,17α-isopropylidenedihydroxypregna-1,4-diene-11β, 21-diol--3,20-dione

  摘要：

  DOI：

  10.1007/bf00777274

文献信息

• Cesium Fluoride Catalyzed Trifluoromethylation of Esters, Aldehydes, and Ketones with (Trifluoromethyl)trimethylsilane
  作者：Rajendra P. Singh、Ganfeng Cao、Robert L. Kirchmeier、Jean'ne M. Shreeve

  DOI：10.1021/jo982494c

  日期：1999.4.1

  low reactivity of carboxylic esters toward (trifluoromethyl)trimethylsilane (TMS-CF(3)) was investigated. A universal cesium fluoride catalyzed procedure for nucleophilic trifluoromethylation was developed. At room temperature (25 degrees C), with catalytic amounts of cesium fluoride, carboxylic esters were found to react to give the silyl ether intermediates, which afforded the trifluoromethyl ketones

  研究了羧酸酯对（三氟甲基）三甲基硅烷（TMS-CF（3））的低反应性。建立了通用的氟化铯催化亲核三氟甲基化反应的方法。在室温（25摄氏度）下，催化量的氟化铯被发现与羧酸酯反应生成甲硅烷基醚中间体，在水解后得到三氟甲基酮。磺酸酯，亚磺酸酯和亚硒酸酯也显示出良好的反应活性，得到了新颖的三氟甲基化化合物。三氟甲基化方法也适用于醛和酮，将其转化为三氟甲基甲硅烷基醚中间体，并在酸水解后以优异的产率得到三氟甲基化的醇。乙二醇二甲醚用作固体或高沸点底物的溶剂，
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Se: MVol.B, 49, page 108 - 111
  作者：

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  日期：——
• Hesse,G.; Majmudar,S., Chemische Berichte, 1960, vol. 93, p. 1129 - 1137
  作者：Hesse,G.、Majmudar,S.

  DOI：——

  日期：——
• Paetzold,R.; Reichenbaecher,M., Zeitschrift fur Chemie, 1970, vol. 10, p. 307 - 308
  作者：Paetzold,R.、Reichenbaecher,M.

  DOI：——

  日期：——
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Se: MVol.B, 64, page 142 - 143
  作者：

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