| 1257307-92-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 1257307-92-8
• 化学式: C₅₄H₄₈N₄O₁₂S₂
• 分子量: 1009.13
• InChiKey: XNSNLROPJJXJEF-ULHREZCRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.36
• 重原子数：
  72.0
• 可旋转键数：
  22.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  222.26
• 氢给体数：
  2.0
• 氢受体数：
  14.0

反应信息

• 作为反应物：
  描述：

  反应 3.0h， 生成
  参考文献：
  名称：

  Design, synthesis and reactivity of C2-symmetric azobenzene-based amino acid-bis(propargyl sulfones)

  摘要：

  C-2-Symmetric azobenzene-amino acid linked bis(propargyl sulfones) 1 and 2 containing stable E azo moiety have been synthesized. Upon irradiation with long wavelength UV these compounds isomerized to the Z-form, whose thermal reisomerization to the E-isomer slowed down considerably Under basic pH, the compounds showed DNA cleavage in mu molar concentrations with the Z-isomers showing better cleaving efficiency. The difference in cleaving efficiency between the Z and the E-isomer is more than the corresponding pair of sulfones without amino acid linker. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.08.085
• 作为产物：
  描述：

  在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 以75%的产率得到
  参考文献：
  名称：

  Design, synthesis and reactivity of C2-symmetric azobenzene-based amino acid-bis(propargyl sulfones)

  摘要：

  C-2-Symmetric azobenzene-amino acid linked bis(propargyl sulfones) 1 and 2 containing stable E azo moiety have been synthesized. Upon irradiation with long wavelength UV these compounds isomerized to the Z-form, whose thermal reisomerization to the E-isomer slowed down considerably Under basic pH, the compounds showed DNA cleavage in mu molar concentrations with the Z-isomers showing better cleaving efficiency. The difference in cleaving efficiency between the Z and the E-isomer is more than the corresponding pair of sulfones without amino acid linker. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.08.085

文献信息

• Design, synthesis and reactivity of C2-symmetric azobenzene-based amino acid-bis(propargyl sulfones)
  作者：Debarati Mitra、Deb Ranjan Banerjee、Amit Kumar Das、Amit Basak

  DOI：10.1016/j.bmcl.2010.08.085

  日期：2010.11

  C-2-Symmetric azobenzene-amino acid linked bis(propargyl sulfones) 1 and 2 containing stable E azo moiety have been synthesized. Upon irradiation with long wavelength UV these compounds isomerized to the Z-form, whose thermal reisomerization to the E-isomer slowed down considerably Under basic pH, the compounds showed DNA cleavage in mu molar concentrations with the Z-isomers showing better cleaving efficiency. The difference in cleaving efficiency between the Z and the E-isomer is more than the corresponding pair of sulfones without amino acid linker. (C) 2010 Elsevier Ltd. All rights reserved.