6-tert-butyl-2-(2'-methoxy-3'-tert-butyl-5'-methylbenzyl)-4-methylphenol | 27996-19-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-tert-butyl-2-(2'-methoxy-3'-tert-butyl-5'-methylbenzyl)-4-methylphenol
• 英文别名: 2-Tert.butyl-4-methyl-6-(2-methoxy-3-tert.butyl-5-methylbenzyl)phenol；2-tert-Butyl-6-(3-tert-butyl-2-methoxy-5-methylbenzyl)-4-methylphenol；2-tert-butyl-6-[(3-tert-butyl-2-methoxy-5-methylphenyl)methyl]-4-methylphenol
• CAS: 27996-19-6
• 化学式: C₂₄H₃₄O₂
• 分子量: 354.533
• InChiKey: FJHIUHYZVJWJPO-UHFFFAOYSA-N

物化性质

• 沸点：
  436.4±33.0 °C(Predicted)
• 密度：
  0.992±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-tert-butyl-2-(2'-methoxy-3'-tert-butyl-5'-methylbenzyl)-4-methylphenol 在 zinc(II) oxide 、 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 12.0h， 生成 2,4-二甲基-6-叔丁基苯酚
  参考文献：
  名称：

  About selective methods of synthesis of 6-tert-butyl-2-methylphenol and 6-tert-butyl-2,4-dimethylphenol

  摘要：

  Vapor phase catalytic methylation with methanol of 2-tert-butylphenol at the temperature 280-300A degrees C proceeds selectively with formation of 6-tert-butyl-2-methylphenol. Elevating reaction temperature above 300A degrees C leads to formation of 2,6-dimethylphenol. Reaction of 2-tert-butylphenol with methanol in alkaline medium in the presence of zinc oxide is shown to lead initially to formation of a mixture of calixarenes and methylenebisphenols that at elevated temperature exert splitting leading in future to 6-tert-butyl-2,4-dimethylphenol. Obtaining it in this reaction from 2,2'-methylenebis-(6-tert-butyl-4-methylphenol) proceeds selectively. Pathways of the reductive methylation of methylenebisphenols with methanol in alkaline medium is considered.

  DOI：

  10.1134/s1070363209060218
• 作为产物：
  描述：

  2,2'-亚甲基双-(4-甲基-6-叔丁基苯酚) 、 硫酸二甲酯 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 生成 6-tert-butyl-2-(2'-methoxy-3'-tert-butyl-5'-methylbenzyl)-4-methylphenol
  参考文献：
  名称：

  Jirackova,L.; Pospisil,J., Collection of Czechoslovak Chemical Communications, 1974, vol. 39, p. 2792 - 2795

  摘要：

  DOI：

文献信息

• Treating arteriosclerosis using benzimidazole compositions
  申请人：Fuji Photo Film Co., Ltd.

  公开号：US05387600A1

  公开（公告）日：1995-02-07

  Disclosed are an antihyperlipidemia or antiarteriosclerosis agent comprising a certain benzimidazole or 2,2'-methylenebisphenol derivative such as 5-dodecanoylamino-2-mercaptobenzimidazole or 2,2'-isobutylidenebis(4,6-dimethyphenol).

  本发明涉及一种抗高脂血症或抗动脉硬化药剂，包括一种苯并咪唑或2,2'-亚甲基双酚衍生物，例如5-十二烷氨基-2-巯基苯并咪唑或2,2'-异丁基亚甲基双(4,6-二甲基苯酚)。
• Pharmaceutical composition and method for treating hyperlipidemia and arteriosclerosis
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0583665A2

  公开（公告）日：1994-02-23

  Disclosed are an antihyperlipidemia or antiarteriosclerosis agent comprising a certain benzimidazole or 2,2'-methylenebisphenol derivative such as 5-dodecanoylamino-2-mercaptobenzimidazole or 2,2'-isobutylidenebis(4,6-dimethyphenol).

  本发明公开了一种抗高脂血症或抗动脉硬化药剂，其中包含某种苯并咪唑或 2,2'-亚甲基双酚衍生物，如 5-十二烷酰氨基-2-巯基苯并咪唑或 2,2'-异亚丁基双(4,6-二甲酚)。
• ESR spectra and kinetics of the disproportionation of substituted phenoxy radicals Coomunication 2. Radicals of 2,4,6-trialkyl-substituted mono-, p-bis-, p-tris-, and p-tetraphenols
  作者：V. A. Roginskii

  DOI：10.1007/bf00953918

  日期：1985.9
• About selective methods of synthesis of 6-tert-butyl-2-methylphenol and 6-tert-butyl-2,4-dimethylphenol
  作者：A. P. Krysin、T. B. Khlebnikova、B. M. Khlebnikov、L. M. Pokrovskii、V. G. Vasil’ev

  DOI：10.1134/s1070363209060218

  日期：2009.6

  Vapor phase catalytic methylation with methanol of 2-tert-butylphenol at the temperature 280-300A degrees C proceeds selectively with formation of 6-tert-butyl-2-methylphenol. Elevating reaction temperature above 300A degrees C leads to formation of 2,6-dimethylphenol. Reaction of 2-tert-butylphenol with methanol in alkaline medium in the presence of zinc oxide is shown to lead initially to formation of a mixture of calixarenes and methylenebisphenols that at elevated temperature exert splitting leading in future to 6-tert-butyl-2,4-dimethylphenol. Obtaining it in this reaction from 2,2'-methylenebis-(6-tert-butyl-4-methylphenol) proceeds selectively. Pathways of the reductive methylation of methylenebisphenols with methanol in alkaline medium is considered.
• Jirackova,L.; Pospisil,J., Collection of Czechoslovak Chemical Communications, 1974, vol. 39, p. 2792 - 2795
  作者：Jirackova,L.、Pospisil,J.

  DOI：——

  日期：——