2-Aethylamino-bernsteinsaeure-dimethylester | 90205-63-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Aethylamino-bernsteinsaeure-dimethylester
• 英文别名: N-ethyl-aspartic acid dimethyl ester；Dimethyl 2-(ethylamino)butanedioate；dimethyl 2-(ethylamino)butanedioate
• CAS: 90205-63-3
• 化学式: C₈H₁₅NO₄
• 分子量: 189.211
• InChiKey: KGQHBVKQSPWWRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  乙胺 、 1,4-dimethyl but-2-enedioate 在 poly((2-methyl-5-sulfonylphenyl)methyl) 作用下， 反应 0.25h， 以94%的产率得到2-Aethylamino-bernsteinsaeure-dimethylester
  参考文献：
  名称：

  Highly efficient procedure for the conjugate addition of amines to electron deficient alkenes

  摘要：

  The novel efficient procedure has been developed for the conjugate addition of amines to electron deficient alkenes. The results showed that the catalyst was very efficient for the reactions with the excellent yields in several minutes. Operational simplicity, without need of any solvent, low cost of the catalyst used, high yields, reusability, excellent chemoselectivity, applicability to large-scale reactions are the key features of this methodology. The article is published in the original.

  DOI：

  10.1134/s0023158410020096

文献信息

• Kralt,T. et al., Recueil des Travaux Chimiques des Pays-Bas, 1961, vol. 80, p. 313 - 324
  作者：Kralt,T. et al.

  DOI：——

  日期：——
• Highly efficient procedure for the conjugate addition of amines to electron deficient alkenes
  作者：An-ping Liao、Ping Lan、Mei Li、Li-hong Lan

  DOI：10.1134/s0023158410020096

  日期：2010.3

  The novel efficient procedure has been developed for the conjugate addition of amines to electron deficient alkenes. The results showed that the catalyst was very efficient for the reactions with the excellent yields in several minutes. Operational simplicity, without need of any solvent, low cost of the catalyst used, high yields, reusability, excellent chemoselectivity, applicability to large-scale reactions are the key features of this methodology. The article is published in the original.