2,2',2'',2'''-[1,4-phenylenebis(methylenenitrilo)]tetraethanol | 19926-06-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2',2'',2'''-[1,4-phenylenebis(methylenenitrilo)]tetraethanol
• 英文别名: α,α'-Bis--p-xylol；p-Xylylenbis(diaethanolamin)；2-[[4-[[Bis(2-hydroxyethyl)amino]methyl]phenyl]methyl-(2-hydroxyethyl)amino]ethanol
• CAS: 19926-06-8
• 化学式: C₁₆H₂₈N₂O₄
• 分子量: 312.409
• InChiKey: JNNFTWFLYSNTHN-UHFFFAOYSA-N

物化性质

• 熔点：
  63-65 °C
• 沸点：
  530.0±45.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  22
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  87.4
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,2',2'',2'''-[1,4-phenylenebis(methylenenitrilo)]tetraethanol 、 氢溴酸 以 水 为溶剂， 以84%的产率得到1,4-bis(morpholinomethyl)benzene
  参考文献：
  名称：

  Synthesis of Novel Aromatic Core Zero Generation Dendrimers

  摘要：

  Bromomethyl arenes used as polyfunctional core of dendrimers were derivatized with diethanolamine branches. The obtained compounds containing 4 or 6 hydroxyl terminal surface groups are highly water-soluble.

  DOI：

  10.5562/cca2568
• 作为产物：
  描述：

  二乙醇胺 、 1,4-对二氯苄 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以89%的产率得到2,2',2'',2'''-[1,4-phenylenebis(methylenenitrilo)]tetraethanol
  参考文献：
  名称：

  [EN] AMINE SYNERGISTS
  [FR] SYNERGISTES AMINES

  摘要：

  本公开涉及一种胺协同剂，包括一种包括带有取代苯环的三级苄胺的胺。该三级胺可以通过多个水溶性基团进行修饰。

  公开号：

  WO2018143923A1

文献信息

• Use of compounds for the prevention of drug-induced cell toxicity
  申请人：Nykjaer Anders

  公开号：US20090110720A1

  公开（公告）日：2009-04-30

  The present invention relates to the use of compounds for the manufacture of a medicament for the prophylaxis and/or treatment of induced cell toxicity, such as nephewrotoxicity and ototoxicity, in particular where the cell toxicity is induced by a medical treatment. In a preferred embodiment, the compounds have at least two nitrogen atoms, more preferably at least two amino groups. The compounds according to the invention are capable of docking binding of cell toxic compounds to the megalin receptor, and thereby inhibiting uptake of the cell toxic compounds into cells. The invention further relates to novel compounds for use in said treatment, as well as a method for reducing the cell toxicity of cell toxic compounds.
• AMINE SYNERGISTS
  申请人：Hewlett-Packard Development Company, L.P.

  公开号：US20200040018A1

  公开（公告）日：2020-02-06

  The present disclosure is drawn to an amine synergist including a tertiary benzylamine with a substituted benzene ring attached to a tertiary amine. The tertiary amine can be modified with multiple water soluble groups.
• [EN] METHODS AND COMPOSITIONS FOR TREATING OPHTHALMIC CONDITIONS VIA MODULATION OF MEGALIN ACTIVITY<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR TRAITER DES CONDITIONS OPHTALMIQUES PAR LA MODULATION DE L'ACTIVITÉ DE MÉGALINE
  申请人：SIRION THERAPEUTICS INC

  公开号：WO2007150046A2

  公开（公告）日：2007-12-27

  [EN] Compounds that cause reversible night blindness may be used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. Provided are methods and compositions using such compounds and their derivatives to treat, for example, the macular degenerations and dystrophies or to alleviate symptoms associated with such ophthalmic conditions. Such compounds and their derivatives may be used as single agent therapy or in combination with other agents or therapies.
  [FR] Cette invention a pour objet des composés qui provoquent une cécité nocturne réversible et qui peuvent être utilisés pour traiter des conditions ophtalmiques associées à la surproduction de produits de déchets qui s'accumulent pendant l'évolution du cycle visuel. Des procédés et compositions sont fournis utilisant de tels composés et leurs dérivés pour traiter, par exemple, les dégénérations maculaires et dystrophies ou pour atténuer les symptômes associés à de telles conditions ophtalmiques. De tels composés et leurs dérivés peuvent être utilisés en tant que thérapie à un seul agent ou en combinaison avec d'autres agents ou thérapies.
• Synthesis of Novel Aromatic Core Zero Generation Dendrimers
  作者：Melinda-Emese Füstös、Tímea-Anita Sipos、Mircea V. Diudea、Gabriel Katona

  DOI：10.5562/cca2568

  日期：——

  Bromomethyl arenes used as polyfunctional core of dendrimers were derivatized with diethanolamine branches. The obtained compounds containing 4 or 6 hydroxyl terminal surface groups are highly water-soluble.
• [EN] AMINE SYNERGISTS<br/>[FR] SYNERGISTES AMINES
  申请人：HEWLETT PACKARD DEVELOPMENT CO

  公开号：WO2018143923A1

  公开（公告）日：2018-08-09

  The present disclosure is drawn to an amine synergist including a tertiary benzylamine with a substituted benzene ring attached to a tertiary amine. The tertiary amine can be modified with multiple water soluble groups.

  本公开涉及一种胺协同剂，包括一种包括带有取代苯环的三级苄胺的胺。该三级胺可以通过多个水溶性基团进行修饰。