| 1452161-55-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1452161-55-5
• 化学式: C₂₃H₃₀O₆
• 分子量: 402.488
• InChiKey: NMEMRKJFEYEWQJ-NUNAXRQHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.58
• 重原子数：
  29.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  66.38
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  (2S,6S)-1,2-O-isopropylidene-4,8-dioxaundeca-10-en-6-ol 在 4-二甲氨基吡啶 、 lithium tri(sec-butyl)borohydride 、 三氟化硼乙醚 、 四丁基氟化铵 、 水 、 sodium hydride 、 戴斯-马丁氧化剂 、 溶剂黄146 、 三乙胺 、 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 氯仿 为溶剂， 反应 67.0h， 生成 、
  参考文献：
  名称：

  Short and Stereocontrolled Cyclic Polyglycerols Synthesis Using BF3·OEt2 Mediated Intramolecular Epoxide-Opening Reaction

  摘要：

  We developed a new method for the stereocontrolled synthesis of cyclic oligoglycerols. Optically pure solketal and epichlorohydrin were coupled with allyl alcohol under aqueous basic conditions to construct a linear triglycerol skeleton. After subsequent steps, the epoxy alcohol (7) obtained was treated with a catalytic amount of BF3 center dot OEt2 in CH2Cl2 to produce in a high yield of the desired cyclic triglycerol through a regioselective, intramolecular epoxide ring-opening reaction.

  DOI：

  10.3987/com-12-s(n)67

文献信息

• Short and Stereocontrolled Cyclic Polyglycerols Synthesis Using BF3·OEt2 Mediated Intramolecular Epoxide-Opening Reaction
  作者：Masahiro Hamada、Takao Kishimoto、Noriyuki Nakajima

  DOI：10.3987/com-12-s(n)67

  日期：——

  We developed a new method for the stereocontrolled synthesis of cyclic oligoglycerols. Optically pure solketal and epichlorohydrin were coupled with allyl alcohol under aqueous basic conditions to construct a linear triglycerol skeleton. After subsequent steps, the epoxy alcohol (7) obtained was treated with a catalytic amount of BF3 center dot OEt2 in CH2Cl2 to produce in a high yield of the desired cyclic triglycerol through a regioselective, intramolecular epoxide ring-opening reaction.