3-[2-[2-(2,6-Dichloroanilino)phenyl]acetyl]oxypropyl pyridine-3-carboxylate | 1447306-09-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-[2-[2-(2,6-Dichloroanilino)phenyl]acetyl]oxypropyl pyridine-3-carboxylate
• 英文别名: 3-[2-[2-(2,6-dichloroanilino)phenyl]acetyl]oxypropyl pyridine-3-carboxylate
• CAS: 1447306-09-3
• 化学式: C₂₃H₂₀Cl₂N₂O₄
• 分子量: 459.329
• InChiKey: OGAQQTJUKMKACX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  77.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  双氯芬酸 在 caesium carbonate 、 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 生成 3-[2-[2-(2,6-Dichloroanilino)phenyl]acetyl]oxypropyl pyridine-3-carboxylate
  参考文献：
  名称：

  Nicotinic acid conjugates of nonsteroidal anti-inflammatory drugs (NSAID’s) and their anti-inflammatory properties

  摘要：

  A series of nicotinic acid conjugates with non-steroidal anti-inflammatory drugs (NSAID's) have been effectively synthesized using TBTU in high yield and purity. All the synthesized conjugates were evaluated for their in vitro anti-inflammatory activity. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ejps.2013.02.007

文献信息

• Nicotinic acid conjugates of nonsteroidal anti-inflammatory drugs (NSAID’s) and their anti-inflammatory properties
  作者：Machhindra Gund、Fazlur-Rahman Nawaz Khan、Amit Khanna、Varadhan Krishnakumar

  DOI：10.1016/j.ejps.2013.02.007

  日期：2013.5

  A series of nicotinic acid conjugates with non-steroidal anti-inflammatory drugs (NSAID's) have been effectively synthesized using TBTU in high yield and purity. All the synthesized conjugates were evaluated for their in vitro anti-inflammatory activity. (C) 2013 Elsevier B.V. All rights reserved.