N-[(acetylamino)(4-nitrophenyl)methyl]acetamide | 40891-07-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(acetylamino)(4-nitrophenyl)methyl]acetamide
• 英文别名: N-[acetylamino(4-nitrophenyl)methyl]-acetamide；N-acetylamino(4-nitrophenyl)methyl acetamide；N,N'-nitrobenzylidenediacetamide；N,N'-(4-nitro-benzylidene)-bis-acetamide；N,N'-(4-Nitro-benzyliden)-bis-acetamid；N-[acetamido-(4-nitrophenyl)methyl]acetamide
• CAS: 40891-07-4
• 化学式: C₁₁H₁₃N₃O₄
• mdl: MFCD00193726
• 分子量: 251.242
• InChiKey: FBYZPCLLQOPFRK-UHFFFAOYSA-N

物化性质

• 熔点：
  272 °C
• 沸点：
  607.8±55.0 °C(Predicted)
• 密度：
  1.280±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 硝酸 作用下， 生成 N-[(acetylamino)(4-nitrophenyl)methyl]acetamide
  参考文献：
  名称：

  Brian; Lamberton, Journal of the Chemical Society, 1949, p. 1635

  摘要：

  DOI：

文献信息

• Choline peroxydisulfate oxidizing Bio-TSIL: triple role player in the one-pot synthesis of Betti bases and gem-bisamides from aryl alcohols under solvent-free conditions
  作者：Balu L. Gadilohar、Haribhau S. Kumbhar、Ganapati S. Shankarling

  DOI：10.1039/c4nj02295e

  日期：——

  The sequential one-pot multicomponent synthesis of Betti bases and bisamides using biodegradable choline persulfate.

  一锅法合成Betti碱和双酰胺，使用可生物降解的胆碱过硫酸盐。
• Synthesis of Symmetrical Bisamides by Reaction between Aromatic Aldehydes and Alkyl Nitriles in the Presence of Chlorosulfonic Acid
  作者：Mohammad Anary-Abbasinejad、Mohammad H. Mosslemin、Alireza Hassanabadi

  DOI：10.3184/030823409x435937

  日期：2009.4

  Reaction between aromatic aldehydes and alkyl nitriles in the presence of chlorosulfonic acid leads to N-[alkanoylamino-(aryl)-methyl]- amide derivatives in excellent yields.

  在氯磺酸的存在下，芳香醛和烷基腈之间的反应会以极好的收率生成 N-[烷酰基氨基-(芳基)-甲基]-酰胺衍生物。
• <i>p</i>-Toluene Sulfonic Acid-Catalysed Microwave Synthesis of Symmetrical Bisamides by Reaction between Aromatic Aldehydes and Amides
  作者：Mohammad Anary-Abbasinejad、Alireza Hassanabadi、Motahareh Heidari-Barfeh

  DOI：10.3184/030823410x12812905400188

  日期：2010.8

  Reaction between aldehydes and amides catalysed by p-toluene sulfonic acid in microwave conditions provided a simple and efficient one-pot route for the synthesis of symmetrical bisamide derivatives in excellent yields.

  在微波条件下由对甲苯磺酸催化的醛和酰胺之间的反应为以优异的产率合成对称双酰胺衍生物提供了一种简单有效的一锅法。
• An Efficient Synthesis of Symmetrical Bisamides Catalysed by Molecular iodine under Neutral Conditions
  作者：Hongshe Wang、June Zeng

  DOI：10.3184/174751912x13383107316656

  日期：2012.8

  An efficient synthesis of symmetrical bisamides is described in which aldehydes are reacted with amides in the presence of 5 mol% of iodine to give the corresponding bisamides in high yields under neutral conditions.

  该方法描述了一种对称双酰胺的高效合成，在中性条件下，醛与酰胺在 5 摩尔%碘的存在下发生反应，得到高产率的相应双酰胺。
• <i>p</i>-Toluene Sulfonic Acid–Catalyzed, Solvent-Free Synthesis of Symmetrical Bisamides by Reaction Between Aldehydes and Amides
  作者：Mohammad Anary-Abbasinejad、Mohammad H. Mosslemin、Alireza Hassanabadi、Safiyeh Tajik Safa

  DOI：10.1080/00397910903219617

  日期：2010.7.12

  Reaction between aldehydes and amides catalyzed by p-toluene sulfonic acid in solvent-free conditions provided a simple and efficient one-pot route for the synthesis of symmetrical bisamide derivatives in excellent yields.

  在无溶剂条件下由对甲苯磺酸催化的醛和酰胺之间的反应为以优异的产率合成对称双酰胺衍生物提供了一种简单有效的一锅法。