cholinium lysinate | 1361335-94-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cholinium lysinate
• 英文别名: choline lysinate；[Ch][Lys]；2-Hydroxy-N,N,N-trimethylethanaminium (S)-2,6-diaminohexanoate；(2S)-2,6-diaminohexanoate;2-hydroxyethyl(trimethyl)azanium
• CAS: 1361335-94-5
• 化学式: C₅H₁₄NO*C₆H₁₃N₂O₂
• 分子量: 249.354
• InChiKey: JFRJUCVTNKRXFH-JEDNCBNOSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.12
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  L-赖氨酸 、 胆碱 以 水 为溶剂， 以91%的产率得到cholinium lysinate
  参考文献：
  名称：

  Cholinium-amino acid based ionic liquids: a new method of synthesis and physico-chemical characterization

  摘要：

  使用更清洁的合成方法制备了十四种基于氨基酸的胆碱盐室温离子液体。化学物理性质与多样的氨基酸化学结构广泛相关。

  DOI：

  10.1039/c5cp01612f

文献信息

• Ionic liquids from renewable biomaterials: synthesis, characterization and application in the pretreatment of biomass
  作者：Qiu-Ping Liu、Xue-Dan Hou、Ning Li、Min-Hua Zong

  DOI：10.1039/c2gc16128a

  日期：——

  A series of room temperature ionic liquids (ILs), in which cholinium acts as the cation and amino acids as the anions, were prepared via a simple and green chemical route, and characterized. Most of the ILs dissolved lignin efficiently and selectively (with solubilities of 140–220 mg of lignin per g of IL). The solubility of xylan in these ILs (which ranged from <1 to 85 mg g−1) depended on the nature of the anion, while cellulose was scarcely soluble (<5 mg g−1). In addition, enzymatic hydrolysis of microcrystalline cellulose and rice straw was enhanced significantly after pretreatment using the IL [Ch][Gly].

  一系列室温离子液体（ILs）被制备，其中胆碱作为阳离子，氨基酸作为阴离子，通过一种简单且环保的化学路线进行制备和表征。大多数ILs能够高效且选择性地溶解木质素（溶解度为每克IL 140–220毫克木质素）。这些ILs中木聚糖的溶解度（范围为<1到85毫克每克）依赖于阴离子的性质，而纤维素几乎不溶解（<5毫克每克）。此外，经过IL [Ch][Gly] 预处理后，微晶纤维素和稻草的酶解水解显著增强。
• Soybean oil-based monoacylglycerol synthesis using bio-compatible amino acid ionic liquid as a catalyst at low temperature
  作者：Shangde Sun、Yaping Lv、Gaoshang Wang、Xiaowei Chen

  DOI：10.1016/j.molliq.2021.117231

  日期：2021.10

  green and safe food additive. This project mainly focused on a nontoxic and biodegradable catalyst, amino acid-based ionic liquids (AAILs), for the glycerolysis of soybean oil triacylglycerol (TAG) to prepare MAG at low temperature. Seven AAILs, from arginine, lysine, histidine, tryptophan, or glutamic acid and choline hydroxide, tetramethylhydroxide ammonium, or tetrabutylammonium hydroxide, were successfully

  食用油中的单酰基甘油（MAG）是一种绿色安全的食品添加剂。该项目主要关注一种无毒且可生物降解的催化剂，氨基酸基离子液体（AAILs），用于在低温下甘油解大豆油三酰甘油（TAG）制备MAG。在这项工作中成功合成了七种 AAIL，分别来自精氨酸、赖氨酸、组氨酸、色氨酸或谷氨酸以及氢氧化胆碱、氢氧化四甲基铵或氢氧化四丁基铵。评价了底物比例、AAIL 负载、温度和反应时间对 AAIL 催化大豆油甘油分解的影响。此外，还探讨了MAG形成的活化能，并提出了反应机理。最后，通过响应面法优化反应条件。结果表明，在所有测试的 AAIL 中，由精氨酸 (Arg) 和四甲基氢氧化铵 (TMAOH) 制备的 [TMA][Arg] 显示出优异的大豆油甘油解催化性能。在以下优化条件下实现了最大 MAG 产率 (64.89 ± 1.26%) 和 TAG 转化率 (86.31 ± 1.68%)：105 °C，0.5 h，[TMA][Arg]
• Yeast host cells and methods for producing fatty alcohols
  申请人：D'Espaux Leopold

  公开号：US10557152B2

  公开（公告）日：2020-02-11

  The present invention provides for a genetically modified yeast cell comprising at least six or more of the following modifications: increased expression of Mus musculus fatty acid reductase, acetyl-CoA carboxylase, fatty acid synthase 1, fatty acid synthase 2, a mutant of the bottleneck enzyme encoded by ACC1 insensitive to post-transcriptional and post-translational repression, and/or a desaturase encoded by OLE1, and reduced expression of DGA1, HFD1, ADH6, and/or GDH1. The present invention provides a method for constructing the genetically modified yeast cell, and a method for producing a fatty alcohol from the genetically modified yeast cell.

  本发明提供了一种转基因酵母细胞，该细胞包含至少六种或六种以上的下列修饰：增加麝香草脂肪酸还原酶、乙酰-CoA羧化酶、脂肪酸合成酶1、脂肪酸合成酶2、对转录后和翻译后抑制不敏感的ACC1编码的瓶颈酶突变体和/或OLE1编码的去饱和酶的表达，以及减少DGA1、HFD1、ADH6和/或GDH1的表达。本发明提供了一种构建转基因酵母细胞的方法，以及一种利用转基因酵母细胞生产脂肪醇的方法。
• Compositions and methods for the dissolution and depolymerization of lignin
  申请人：National Technology & Engineering Solutions of Sandia, LLC

  公开号：US10703770B2

  公开（公告）日：2020-07-07

  The present invention provides for a method for dissolving and/or depolymerizing lignin comprising: (a) providing a composition comprising lignin, (b) contacting the composition with a strong hydrogen donor, such as a polyol, to form a first solution, (c) incubating the first solution at a temperature equal to or less than 100° C., whereby at least 20% by weight of the lignin is dissolved, (d) optionally introducing an oxidation agent to the first solution to form a second solution, wherein the temperature of the second solution is equal to or less than 100° C., whereby lignin is depolymerized, and (e) optionally introducing an anti-solvent to the second solution to precipitate the depolymerized lignin.

  本发明提供了一种溶解和/或解聚木质素的方法，该方法包括：(a) 提供包含木质素的组合物，(b) 将该组合物与强氢供体（如多元醇）接触以形成第一溶液，(c) 在等于或低于 100°C 的温度下培养第一溶液，其中至少 20% （重量）的木质素被溶解，(d) 可选地将氧化剂引入第一溶液以形成第二溶液，其中第二溶液的温度等于或低于 100°C 、(d) 可选地将氧化剂引入第一溶液以形成第二溶液，其中第二溶液的温度等于或低于 100°C，从而使木质素解聚，以及 (e) 可选地将抗溶剂引入第二溶液以沉淀解聚的木质素。
• Lignin valorization in ionic liquids and deep eutectic solvent via catalysis and biocatalysis
  申请人：University of Kentucky Research Foundation

  公开号：US10723859B2

  公开（公告）日：2020-07-28

  This invention relates to a method for extracting valorized compounds from lignin by contacting lignins with an ionic liquid and/or a deep eutectic solvent and adding a catalyst and/or a biocatalyst to assist in breaking down the source material. Converting lignin into high value chemicals adds revenues for a bio-refinery and helps to improve the economic viability of biofuel production.

  本发明涉及一种从木质素中提取有价化合物的方法，方法是将木质素与离子液体和/或深共晶溶剂接触，并加入催化剂和/或生物催化剂以帮助分解源材料。将木质素转化为高价值化学品可增加生物精炼厂的收入，并有助于提高生物燃料生产的经济可行性。