L-aspartic acid ; choline salt | 143896-91-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-aspartic acid ; choline salt
• 英文别名: L-Asparaginsaeure; Cholin-Salz
• CAS: 143896-91-7
• 化学式: C9H20N2O5
• 分子量: 236.27
• InChiKey: FCCOUWYDJMINGX-WNQIDUERSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -4.0
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Cholinium-amino acid based ionic liquids: a new method of synthesis and physico-chemical characterization
  作者：Serena De Santis、Giancarlo Masci、Francesco Casciotta、Ruggero Caminiti、Eleonora Scarpellini、Marco Campetella、Lorenzo Gontrani

  DOI：10.1039/c5cp01612f

  日期：——

  Fourteen cholinium-amino acid based room temperature ionic liquids were prepared using a cleaner synthetic method. Chemicophysical properties were well correlated with the wide range of amino acid chemical structures.

  使用更清洁的合成方法制备了十四种基于氨基酸的胆碱盐室温离子液体。化学物理性质与多样的氨基酸化学结构广泛相关。
• Ionic liquids from renewable biomaterials: synthesis, characterization and application in the pretreatment of biomass
  作者：Qiu-Ping Liu、Xue-Dan Hou、Ning Li、Min-Hua Zong

  DOI：10.1039/c2gc16128a

  日期：——

  A series of room temperature ionic liquids (ILs), in which cholinium acts as the cation and amino acids as the anions, were prepared via a simple and green chemical route, and characterized. Most of the ILs dissolved lignin efficiently and selectively (with solubilities of 140–220 mg of lignin per g of IL). The solubility of xylan in these ILs (which ranged from <1 to 85 mg g−1) depended on the nature of the anion, while cellulose was scarcely soluble (<5 mg g−1). In addition, enzymatic hydrolysis of microcrystalline cellulose and rice straw was enhanced significantly after pretreatment using the IL [Ch][Gly].

  一系列室温离子液体（ILs）被制备，其中胆碱作为阳离子，氨基酸作为阴离子，通过一种简单且环保的化学路线进行制备和表征。大多数ILs能够高效且选择性地溶解木质素（溶解度为每克IL 140–220毫克木质素）。这些ILs中木聚糖的溶解度（范围为<1到85毫克每克）依赖于阴离子的性质，而纤维素几乎不溶解（<5毫克每克）。此外，经过IL [Ch][Gly] 预处理后，微晶纤维素和稻草的酶解水解显著增强。
• Yeast host cells and methods for producing fatty alcohols
  申请人：D'Espaux Leopold

  公开号：US10557152B2

  公开（公告）日：2020-02-11

  The present invention provides for a genetically modified yeast cell comprising at least six or more of the following modifications: increased expression of Mus musculus fatty acid reductase, acetyl-CoA carboxylase, fatty acid synthase 1, fatty acid synthase 2, a mutant of the bottleneck enzyme encoded by ACC1 insensitive to post-transcriptional and post-translational repression, and/or a desaturase encoded by OLE1, and reduced expression of DGA1, HFD1, ADH6, and/or GDH1. The present invention provides a method for constructing the genetically modified yeast cell, and a method for producing a fatty alcohol from the genetically modified yeast cell.

  本发明提供了一种转基因酵母细胞，该细胞包含至少六种或六种以上的下列修饰：增加麝香草脂肪酸还原酶、乙酰-CoA羧化酶、脂肪酸合成酶1、脂肪酸合成酶2、对转录后和翻译后抑制不敏感的ACC1编码的瓶颈酶突变体和/或OLE1编码的去饱和酶的表达，以及减少DGA1、HFD1、ADH6和/或GDH1的表达。本发明提供了一种构建转基因酵母细胞的方法，以及一种利用转基因酵母细胞生产脂肪醇的方法。
• Adjusting the pH of a pretreatment solution using carbon dioxide useful for integrating saccharification and fermentation
  申请人：National Technology & Engineering Solutions of Sandia, LLC

  公开号：US10837038B2

  公开（公告）日：2020-11-17

  The present invention provides for a method of fermenting or saccharifying a biomass comprising: (a) (i) contacting a biomass comprising a polysaccharide, and an ionic liquid (IL) to form a first solution, or (ii) providing the first solution comprising the biomass and the IL, (b) contacting the first solution and carbon dioxide such that the first solution results in a lower pH, (c) introducing (i) an enzyme capable of enzymatically to breakdown at least one bond in the polysaccharide or a breakdown product of the polysaccharide, and/or (ii) a microorganism that capable of producing the enzyme and/or fermenting the polysaccharide or a breakdown product of the polysaccharide, such that the polysaccharide is at least partially broken down and the first solution is transformed into a second solution.

  本发明提供了一种发酵或糖化生物质的方法，包括(a) (i) 将包含多糖的生物质与离子液体（IL）接触以形成第一溶液，或 (ii) 提供包含生物质和离子液体的第一溶液，(b) 将第一溶液与二氧化碳接触，使第一溶液的 pH 值降低、(c) 引入 (i) 能够酶解多糖中至少一个键的酶或多糖的分解产物，和/或 (ii) 能够产生酶和/或发酵多糖或多糖分解产物的微生物，从而至少部分分解多糖，将第一种溶液转化为第二种溶液。
• High gravity, fed-batch ionic liquid based process for deconstructing biomass
  申请人：NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC

  公开号：US11118197B2

  公开（公告）日：2021-09-14

  In one aspect, the present invention provides methods for preparing a fermentation product. The methods include pre-treating a mixture of biomass and ionic liquid, wherein the ionic liquid comprises a choline cation and the biomass comprises polysaccharide and lignin. The methods further include forming hydrolysates from the introduction of glycoside hydrolase to the pre-treated mixture at conditions sufficient to produce a sugar composition mixture for fermentation steps. The present invention provides methods for loading biomass mixtures in a batch-fed process, wherein the biomass slurries can be loaded into water or a concentrated sugar composition for hydrolysate production. The methods can be performed in a one-pot process, wherein the ionic liquids are present in the mixtures throughout each step. Aspects of the invention provide compositions of sugar composition mixtures and fermentation product mixtures.

  一方面，本发明提供了制备发酵产品的方法。这些方法包括预处理生物质和离子液体的混合物，其中离子液体包括胆碱阳离子，生物质包括多糖和木质素。该方法还包括在足以产生用于发酵步骤的糖成分混合物的条件下，将糖苷水解酶引入预处理混合物，形成水解物。本发明提供了在分批进料工艺中装载生物质混合物的方法，其中生物质浆料可装入水或浓缩的糖组合物中以生产水解物。这些方法可以在单锅工艺中进行，其中离子液体在每个步骤中都存在于混合物中。本发明的各个方面提供了糖组合物混合物和发酵产物混合物的组成。