Provided is a drug substance and a method of treating an ailment comprising administering an oral dose of a drug product comprising the drug substance wherein the drug substance comprises an organic acid addition salt of methadone. The organic acid addition salt is selected from the group consisting of pamoate and xinafoate wherein the drug substance is bioavailable under gastrointestinal administration but is not bioavailable under administration at a mucosal membrane other than gastrointestinal or release from a depot injectable product.
本文提供了一种药物物质和治疗方法,包括给予一种药物产品的口服剂量,该药物产品包括所述药物物质,其中所述药物物质包括
美沙酮的有机酸加成盐。所述有机酸加成盐选自沙酸盐和西那福酸盐的群体,其中所述药物物质在胃肠道给药下具有
生物利用度,但在黏膜膜以外的其他部位给药或从释放出的深层注射产品中不具有
生物利用度。