2,6-diisopropylphenol linoleic acid | 1338939-13-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,6-diisopropylphenol linoleic acid
• 英文别名: 2,6-Diisopropylphenol-Linoleic Acid；[2,6-di(propan-2-yl)phenyl] (9Z,12Z)-octadeca-9,12-dienoate
• CAS: 1338939-13-1
• 化学式: C₃₀H₄₈O₂
• 分子量: 440.71
• InChiKey: ISQFTVNKQIPPCZ-XVTLYKPTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.7
• 重原子数：
  32
• 可旋转键数：
  18
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (Z,Z)-9,12-十八烷二烯酸二聚物 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 10.17h， 生成 2,6-diisopropylphenol linoleic acid
  参考文献：
  名称：

  Synthesis and characterization of novel PUFA esters exhibiting potential anticancer activities: An in vitro study

  摘要：

  Polyunsaturated fatty acids (PUFAs) have been reported to play a regulatory role in tumour growth progression. In the present study, we have synthesized ester derivatives of two important PUFA viz., linoleic acid (LA) and arachidonic acid (AA) with propofol, a widely used general anaesthetic-sedative agent. The novel propofol ester analogues have been found to inhibit various cancer cell lines in a dose-dependent manner. Moreover, the compounds have been found to induce apoptotic cell death by enhancing the release of cytochrome c and expression of caspase-3. The data of the present study suggest that novel propofol PUFA esters have strong potential to emerge as effective anticancer agents. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.07.044

文献信息

• Synthesis and characterization of novel PUFA esters exhibiting potential anticancer activities: An in vitro study
  作者：Azmat Ali Khan、Mahboob Alam、Saba Tufail、Jamal Mustafa、Mohammad Owais

  DOI：10.1016/j.ejmech.2011.07.044

  日期：2011.10

  Polyunsaturated fatty acids (PUFAs) have been reported to play a regulatory role in tumour growth progression. In the present study, we have synthesized ester derivatives of two important PUFA viz., linoleic acid (LA) and arachidonic acid (AA) with propofol, a widely used general anaesthetic-sedative agent. The novel propofol ester analogues have been found to inhibit various cancer cell lines in a dose-dependent manner. Moreover, the compounds have been found to induce apoptotic cell death by enhancing the release of cytochrome c and expression of caspase-3. The data of the present study suggest that novel propofol PUFA esters have strong potential to emerge as effective anticancer agents. (C) 2011 Elsevier Masson SAS. All rights reserved.