12,13-epoxy octadecenoic acid | 503-07-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 12,13-epoxy octadecenoic acid
• 英文别名: 12(13)-EpOME；11-(3-pentyl-oxiranyl)-undec-9-enoic acid；Vernolinsaeure；Vemolsaeure；(E)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
• CAS: 503-07-1；6799-85-5；17966-13-1；28396-98-7；31263-20-4；32381-42-3；38003-78-0；75918-47-7；110658-05-4；126639-26-7；133965-00-1
• 化学式: C₁₈H₃₂O₃
• 分子量: 296.45
• InChiKey: CCPPLLJZDQAOHD-DHZHZOJOSA-N

物化性质

• 沸点：
  395.8±15.0 °C(Predicted)
• 密度：
  0.969±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  21
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2918990090

反应信息

• 作为产物：
  描述：

  (Z,Z)-9,12-十八烷二烯酸二聚物 、 亚麻酸 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 生成 12,13-epoxy octadecenoic acid 、 9,10-trans-epoxy-octadeca-9E-enoic acid
  参考文献：
  名称：

  哺乳动物环氧化物水解酶与顺式和反式脂肪酸环氧化物的催化活性与皮肤屏障功能相关。

  摘要：

  脂氧合酶 (LOX) 催化必需脂肪酸亚油酸的氧化，是构建哺乳动物表皮渗透屏障的重要步骤。表皮脂质分析表明，亚油酸酯通过环氧羟基前体的水解转化为三羟基衍生物。我们评估了不同的环氧化物水解酶（EH）在皮肤相关脂肪酸环氧化物水解中的作用，并将产物与酸催化水解的产物进行了比较。在没有酶的情况下，在 37°C 下暴露于 pH 5 或 pH 6 中 30 分钟，将脂肪酸烯丙环氧醇水解为四种三羟基产物。相比之下，人可溶性 EH [sEH (EPHX2)] 和人或鼠环氧化物水解酶 3 [EH3 (EPHX3)] 将顺式或反式烯丙环氧化物水解为单一非对映体，与表皮中检测到的主要异构体相同。微粒体 EH [mEH (EPHX1)] 对这些底物没有活性。在低底物浓度 (<10 μM) 下，EPHX2 水解 14,15-环氧二十碳三烯酸 (EET) 的速度是表皮环氧醇 9R,10R-反式-环氧-11E-13R-羟基-十八烯酸的两倍，而人类或小鼠

  DOI：

  10.1194/jlr.m082701

文献信息

• Amphiphilic derivatives for the production of vesicles, micelles and complexants, and precursors thereof
  申请人：Grinberg Sarina

  公开号：US20050118248A1

  公开（公告）日：2005-06-02

  Amphiphilic derivatives composed of at least one fatty acid chain are derived from natural vegetable oils such as vernonia oil, lesquerella oil and castor oil, in which the several reactive groups such as epoxy, hydroxy and double bonds can be modified to polar and ionic groups. The head group of the amphiphilic derivative may be in the main fatty acid chain or in a side chain. The amphiphiles are useful for the formation of vesicles and micelles and for use as complexants and surfactants.

  由至少一个脂肪酸链组成的亲水亲油衍生物是从天然植物油中派生出来的，例如vernonia油、lesquerella油和蓖麻油，在这些油中，几种反应性基团如环氧、羟基和双键可以改性为极性和离子基团。这种亲水亲油衍生物的头基团可以在主要的脂肪酸链或侧链中。这些亲水亲油分子可用于形成囊泡和胶束，并可用作络合剂和表面活性剂。
• NANO-SIZED PARTICLES COMPRISING MULTI-HEADED AMPHIPHILES FOR TARGETED DRUG DELIVERY
  申请人：Linder Charles

  公开号：US20120164072A1

  公开（公告）日：2012-06-28

  Nano-sized particles are provided comprising at least one multi-headed amphiphilic compound, in which at least one headgroup of said multi-headed amphiphilic compound is selectively cleavable or contains a selectively cleavable group, and at least one biologically active agent, which is both encapsulated within the nano-particle and non-covalently associated thereto.

  提供了一种纳米级颗粒，其中包含至少一种多头亲疏水化合物，其中至少一个头基团是可选择性断裂的或含有可选择性断裂基团，并且至少一种生物活性剂被封装在纳米粒子内并与其非共价结合。
• A method of inducing antitumor immunocytes, and a process for producing antitumor immunocytes and antitumor immunocytes produced by the process
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0147689A2

  公开（公告）日：1985-07-10

  A method of inducing antitumor immunocytes which is simple in operation and suitable for inducing antitumor immunocytes having not only excellent cytotoxic activity against tumor cells but also high safety, which method comprises contacting leucocytes with an insoluble, antitumor immunocyte-inducing material capable of linking with T cells, said antitumor immunocyte-inducing material comprising an insoluble carrier and a ligand linked therewith. The induced antitumor immunocytes can be simply separated in substantially ligand-free form from the insoluble, antitumor immunocyte-inducing material. The obtained antitumor immunocytes have not only excellent cytotoxic activity against tumor cells but also high safety.

  一种诱导抗肿瘤免疫细胞的方法，该方法操作简单，适用于诱导抗肿瘤免疫细胞，不仅对肿瘤细胞具有优异的细胞毒活性，而且安全性高，该方法包括使白细胞与不溶性的、能与 T 细胞连接的抗肿瘤免疫细胞诱导材料接触，所述抗肿瘤免疫细胞诱导材料包括不溶性载体和与之连接的配体。 可以简单地将诱导的抗肿瘤免疫细胞以基本上不含配体的形式从不溶性的抗肿瘤免疫细胞诱导材料中分离出来。 获得的抗肿瘤免疫细胞不仅对肿瘤细胞具有优异的细胞毒活性，而且安全性高。
• Thermal dye sublimation transfer receiving element
  申请人：AGFA-GEVAERT naamloze vennootschap

  公开号：EP0481130A1

  公开（公告）日：1992-04-22

  Dye-image receiving element for use according to thermal dye sublimation transfer comprising a support having thereon a dye-image receiving layer containing a (co)polyester comprising condensation residues of one or more diols and one or more dicarboxylic acids and further comprising condensation residues of one or more hydroxy-carboxylic acids containing a long chain alkyl or alkylene group having at least 8 carbon atoms.

  用于热染料升华转移的染料图像接收元件，包括一个支架，支架上有一个染料图像接收层，染料图像接收层含有一种（共）聚酯，该聚酯由一种或多种二元醇和一种或多种二羧酸的缩合残留物组成，还包括一种或多种羟基羧酸的缩合残留物，该羟基羧酸含有至少 8 个碳原子的长链烷基或亚烷基。
• Codon-optimized epoxygenases / hydroxylases
  申请人：Divergence, Inc.

  公开号：EP2182062A2

  公开（公告）日：2010-05-05

  The present invention provides DNA constructs, transgenic plants containing such constructs, and methods of making the plants. The DNA constructs encode a polypeptide that when expressed results in the production of fatty acid compounds having anthelmintic activity. Transgenic plants expressing such a polypeptide can exhibit enhanced resistance to plant parasitic nematodes, particularly when expressed in vegetative tissues. Transgenic plants expressing such a polypeptide can also be useful for non-pesticidal industrial uses.

  本发明提供了 DNA 构建体、含有这种构建体的转基因植物以及制造这种植物的方法。DNA 构建体编码一种多肽，该多肽表达后可产生具有驱虫活性的脂肪酸化合物。表达这种多肽的转基因植物对植物寄生线虫的抗性增强，尤其是在无性组织中表达时。表达这种多肽的转基因植物还可用于非杀虫工业用途。