2,2-Dimethyl-propionic acid 2-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-oxo-cyclohex-1-enylmethyl ester | 193334-92-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2-Dimethyl-propionic acid 2-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-oxo-cyclohex-1-enylmethyl ester
• CAS: 193334-92-8
• 化学式: C₂₄H₃₆O₄Si
• 分子量: 416.633
• InChiKey: MZRNJCYPDUVHRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.17
• 重原子数：
  29.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  52.6
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2,2-Dimethyl-propionic acid 2-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-oxo-cyclohex-1-enylmethyl ester 在 1,3-二甲基-2-咪唑啉酮 、 potassium cyanide 、 tris(dibenzylideneacetone)dipalladium(0) chloroform complex 、 copper(l) iodide 、 正丁基锂 、 sodium hydride 、 二异丁基氢化铝 、 silver nitrate 、 正丁胺 作用下， 以 甲苯 、 苯 为溶剂， 反应 27.5h， 生成 [(R)-2-[3-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-3-methoxy-3-((Z)-6-trimethylsilanyl-hex-3-ene-1,5-diynyl)-cyclohex-1-enyl]-methanol
  参考文献：
  名称：

  Cross-coupling approach towards dynemicin analogs without the nitrogen

  摘要：

  Utilizing a cross-coupling reaction between the arylstannane 5 and the iodoenone 7, the arylcyclohexenone 8 was prepared. This compound was then transformed into the enediyne aldehydes 16a,b. Treatment of 16a with cat. amounts of TBAF gave rise to the macrocyclic dynemicin analog 17a. This was converted to the phenolic enediyne 18. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00616-9
• 作为产物：
  描述：

  (3-oxocyclohex-1-en-1-yl)methyl pivalate 在 吡啶 、 tris(dibenzylideneacetone)dipalladium(0) chloroform complex 、 copper(l) iodide 、 三苯胂 、 叠氮基三甲基硅烷 、 碘 作用下， 以 various solvent(s) 为溶剂， 反应 47.0h， 生成 2,2-Dimethyl-propionic acid 2-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-oxo-cyclohex-1-enylmethyl ester
  参考文献：
  名称：

  Cross-coupling approach towards dynemicin analogs without the nitrogen

  摘要：

  Utilizing a cross-coupling reaction between the arylstannane 5 and the iodoenone 7, the arylcyclohexenone 8 was prepared. This compound was then transformed into the enediyne aldehydes 16a,b. Treatment of 16a with cat. amounts of TBAF gave rise to the macrocyclic dynemicin analog 17a. This was converted to the phenolic enediyne 18. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00616-9

文献信息

• Cross-coupling approach towards dynemicin analogs without the nitrogen
  作者：Folkert Boße、Ashok Rao Tunoori、Martin E. Maier

  DOI：10.1016/s0040-4020(97)00616-9

  日期：1997.7

  Utilizing a cross-coupling reaction between the arylstannane 5 and the iodoenone 7, the arylcyclohexenone 8 was prepared. This compound was then transformed into the enediyne aldehydes 16a,b. Treatment of 16a with cat. amounts of TBAF gave rise to the macrocyclic dynemicin analog 17a. This was converted to the phenolic enediyne 18. (C) 1997 Elsevier Science Ltd.