erythro-3-hydroxyglutamic acid | 533-62-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: erythro-3-hydroxyglutamic acid
• 英文别名: DL-erythro-3-hydroxy-glutamic acid；DL-erythro-2-Amino-3-hydroxy-glutarsaeure；DL-erythro-3-Hydroxy-glutaminsaeure；(+/-)-2-Amino-3-hydroxy-pentandisaeure；Erythro-beta-hydroxy-D-glutamic acid；(2R,3R)-2-amino-3-hydroxypentanedioic acid
• CAS: 533-62-0；5985-23-9；6208-97-5；6208-98-6；6208-99-7；6209-00-3；10303-67-0；13593-84-5；17093-76-4；17598-55-9；18304-61-5；25541-20-2；50896-27-0
• 化学式: C₅H₉NO₅
• 分子量: 163.13
• InChiKey: LKZIEAUIOCGXBY-VVJJHMBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.5
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  121
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  erythro-3-hydroxyglutamic acid 在 盐酸 、 sodium nitrite 作用下， 生成 (2R,3R)-3-hydroxy-5-oxooxolane-2-carboxylic acid
  参考文献：
  名称：

  Synthesis of beta-L-2'-deoxy nucleosides

  摘要：

  提供了一种改进的2'-改性核苷和2'-脱氧核苷的制备工艺，例如，β-L-2'-脱氧胸苷（LdT）。特别是，改进的工艺针对的是2'-脱氧核苷的合成，该合成可能使用不同的起始材料，但都通过氯糖中间体或通过2,2'-脱水-1-呋喃糖核苷中间体进行。当使用2,2'-脱水-1-呋喃糖碱基中间体时，会采用还原剂（如Red-Al）和隔离剂（如15-冠-5醚），它们能引起分子内位移反应，并形成所需核苷产品的高收率。本发明的一种替代工艺使用2,2'-脱水-1-呋喃糖碱基中间体而不使用隔离剂，也能以高收率获得2'-脱氧核苷。根据本发明制成的化合物可以作为制备其他核苷类似物的中间体，或者可以直接用作抗病毒和/或抗肿瘤剂。

  公开号：

  US20050059632A1
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 作用下， 生成 erythro-3-hydroxyglutamic acid
  参考文献：
  名称：

  Kaneko et al., Nippon Kagaku Zasshi, 1959, vol. 80, p. 316,320

  摘要：

  DOI：

文献信息

• Abderhalden; Murke, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1937, vol. 247, p. 227,234
  作者：Abderhalden、Murke

  DOI：——

  日期：——
• Harington; Randall, Biochemical Journal, 1931, vol. 25, p. 1921
  作者：Harington、Randall

  DOI：——

  日期：——
• Dakin, Journal of Biological Chemistry, 1941, vol. 140, p. 849
  作者：Dakin

  DOI：——

  日期：——
• Chibnall; Westall, Biochemical Journal, 1932, vol. 26, p. 127
  作者：Chibnall、Westall

  DOI：——

  日期：——
• The impact of gender, body dimension and body composition on hand-grip strength in healthy children
  作者：A. Sartorio、C. L. Lafortuna、S. Pogliaghi、L. Trecate

  DOI：10.1007/bf03344033

  日期：2002.5

  Maximum hand-grip (HG) strength, body composition and main anthropometric variables were evaluated in 278 children with normal weight and growth, aged 5-15 yr divided into 3 age groups: group 1, age+/-SD: 7.6+/-0.9 yr 7.6+/-0.9 SD (Tanner stage 1); group 2, age: 10.8+/-0.7 yr (Tanner stage: 2-3); group 3, age: 1 3.2+/-0.9 yr (Tanner stage: 4-5). Weight, height, body surface area (BSA), BMI, percent body fat (BF) and fat free mass (FFM) increased progressively and significantly from the younger to the older age group. A significant difference between genders was detected only for BF and FFM, females having a higher fat mass and a lower FFM compared to males. Most children were right-handed (91%). In either genders, a curvilinear relation was detected between HG strength and age, with best fit for the dominant (d) hand given by the equations: dHG=5.891 *10(0.051 age), r(2)=0.986, p<0.001 in males and dHG=6.163 *10(0.045 age), r(2)=0.973, p<0.001 in females. The increase in HG strength after 11 yr appears to be steeper in males as compared with that found in females. In both d and non-dominant (nd) hand, a significant difference in HG strength was detected between males and females, the average difference being about 10% at all ages. For both genders, nd hand was significantly weaker than d hand in the older age groups (2 and 3), but not in the younger group 1. Age and gender-dependent differences in HG strength (but not differences between d and nd hand) disappear if HG strength is normalized for FFM. Thus, in general, dHG strength normalized for FFM resulted on average to be 0.67+/-0.11 kg/kg. A multiple linear regression analysis indicated that HG was positively correlated with BMI, BSA, stature, stature(2) and FFM (p<0.001 for all correlations) without differences between genders, while a negative correlation was found between HG strength and %BF. The most significant correlation was found between HG strength and FFM, without any significant difference between genders, so that the overall equation describing the line for the d hand was: dHG strength = 2.32+0.63 FFM, r(2)=0.72, p<0.001. In conclusion, the present study indicates that the age-dependent increase of HG strength as well as the between-gender differences are strongly related to changes of FFM values occurring during childhood. Moreover, the study provides a standard normative value of maximal HG strength for the healthy children population in Northern Italy.