5-(2-氧代-3,3a,4,5,6,6a-六氢-1H-环戊二烯并[d]咪唑-6-基)戊酸 | 37842-47-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 5-(2-氧代-3,3a,4,5,6,6a-六氢-1H-环戊二烯并[d]咪唑-6-基)戊酸
• 英文名称: Carbobiotin
• 英文别名: 5-(2-oxo-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[d]imidazol-4-yl)pentanoic acid
• CAS: 37842-47-0
• 化学式: C₁₁H₁₈N₂O₃
• 分子量: 226.27
• InChiKey: HASKQZMOBUQJPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• QUINONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
  申请人：Kelley Mark R.

  公开号：US20100297113A1

  公开（公告）日：2010-11-25

  This application describes quinone derivatives which target the redox site of Ape1/Ref1. Also included in the invention are pharmaceutical formulations containing the derivatives and therapeutic uses of the derivatives.

  这个应用描述了目标为Ape1/Ref1的氧化还原位点的醌衍生物。发明还包括含有这些衍生物的药物制剂和这些衍生物的治疗用途。
• MODIFIED BIOTIN-BINDING PROTEINS FOR IMMOBILIZATION
  申请人：Pacific Biosciences Of California, Inc.

  公开号：EP3729090A1

  公开（公告）日：2020-10-28
• Use of compounds for the prevention of drug-induced cell toxicity
  申请人：Nykjaer Anders

  公开号：US20070004727A1

  公开（公告）日：2007-01-04

  The present invention relates to the use of compounds for the manufacture of a medicament for the prophylaxis and/or treatment of induced cell toxicity, such as nephrotoxicity and ototoxicity, in particular where the cell toxicity is induced by a medical treatment. In a preferred embodiment the compounds have at least two nitrogen atoms, more preferably at least two amino groups. The compounds according to the invention are capable of blocking binding of cell toxic compounds to the megalin receptor, and thereby inhibiting uptake of the cell toxic compounds into cells. The invention further relates to novel compounds for use in said treatment, as well as a method for reducing the cell toxicity of cell toxic compounds.
• US9089605B2
  申请人：——

  公开号：US9089605B2

  公开（公告）日：2015-07-28