5-fluoro-2-methyl-indanone-3-acetic acid | 38226-47-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 5-fluoro-2-methyl-indanone-3-acetic acid
• 英文别名: 2-(6-Fluoro-2-methyl-3-oxo-1,2-dihydroinden-1-yl)acetic acid
• CAS: 38226-47-0
• 化学式: C₁₂H₁₁FO₃
• 分子量: 222.216
• InChiKey: QPOYQXHNRNSHEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-fluoro-2-methyl-indanone-3-acetic acid 在 sodium hydroxide 、 sodium borohydrid 作用下， 以 异丙醇 为溶剂， 生成 5-fluoro-2-methyl-indanol-3-acetic acid
  参考文献：
  名称：

  Process of preparing

  摘要：

  该发明涉及改进的制备5-氟-2-甲基-1-(对甲磺基苯基亚甲基)-茚基-3-乙酸的过程，以及其中间体的制备，以及所述中间体的制备。

  公开号：

  US03998875A1
• 作为产物：
  描述：

  benzyl 3-(2-benzyloxy-2-oxoethylidene)-5-fluoro-2-methyl-1-oxo-2,3-dihydro-1H-indene-2-carboxylate 在 10% Pt/activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 20.0 ℃ 、2.0 MPa 条件下， 以91%的产率得到5-fluoro-2-methyl-indanone-3-acetic acid
  参考文献：
  名称：

  Synthesis of Functionalized Alkylidene Indanes and Indanones through Tandem Phosphine–Palladium Catalysis

  摘要：

  Densely functionalized alkylidene indanes and indanones can be prepared efficiently in On pot, in high yields with good stereoselectivities (in some cases exclusively the Z-isomer), through a route involving phosphine-catalyzed Michael addition followed by palladium-catalyzed Heck cyclization. These transformations tolerate substrates bearing various substituents around the indane/indanone motif. Employing this technology, a concise formal synthesis of sulindac, nonsteroidal anti-inflammatory drug, has been established.

  DOI：

  10.1021/acs.orglett.5b00554

文献信息

• Method for treating patients with diabetic retinopathy by administering substituted sulfonyl indenyl acetic acids and alcohols
  申请人：——

  公开号：US20010006965A1

  公开（公告）日：2001-07-05

  Substituted indenyl sulfonyl acetic acids, esters and alcohols are useful in the treatment of diabetic retinopathy.

  取代基苯并磺酰乙酸、酯和醇在糖尿病视网膜病变的治疗中很有用。
• Method for treating patients with macular degeneration by administering substituted sulfonyl indenyl acetic acids and alcohols
  申请人：——

  公开号：US20010020020A1

  公开（公告）日：2001-09-06

  Substituted indenyl sulfonyl acetic acids, esters and alcohols are useful in the treatment of macular degeneration.

  取代基苯甲酸、酯和醇在治疗黄斑变性中是有用的。
• Method for treating patients with neoplasia by administering substituted sulfonyl indenyl acetic and propionic acids and esters thereof
  申请人：——

  公开号：US20020107248A1

  公开（公告）日：2002-08-08

  Substituted indenyl sulfonyl acetic acids are useful in the treatment of precancerous lesions.

  取代的茚基磺酰乙酸在治疗癌前病变方面是有用的。
• Esters and amides of substituted indenyl acetic acids
  申请人：FGN, INC.

  公开号：EP0485172A2

  公开（公告）日：1992-05-13

  Esters and amides of substituted indenyl acetic acids of the formula : n is an integer of at least 2 ; Q is a deprotonated residue of polymer or macromolecular structure having a molecular weight of at least about 1000 containing at least two primary and/or secondary amino groups and/or hydroxy groups ; R1 is selected from hydrogen, lower alkyl, or haloalkyl ; R2 is selected from hydrogen or alkyl ; R3 and R4 are one or more members each independently chosen from hydrogen, alkyl, acyloxy, alkoxy, nitro, amino, acylamino, alkylamino, diakylamino, dialkylaminoalkyl, sulfamyl, alkythio, mercapto, hydroxy, hydroxyalkyl, alkylsulfonyl, halogen, cyano, carboxyl, carbalkoxy, carbamido, haloalkyl or cycloalkoxy ; and R5 is selected from alkylsulfenyl, alkylsulfinyl or alkylsulfonyl. are useful in the treatment of colonic polyps.

  式中的取代茚基乙酸的酯和酰胺： n 至少为 2 的整数； Q 是聚合物或大分子结构的去质子化残基，分子量至少约为 1000，含有至少两个伯氨基和/或仲氨基和/或羟基； R1 选自氢、低级烷基或卤代烷基； R2 选自氢或烷基； R3 和 R4 是各自独立选自氢、烷基、酰氧基、烷氧基、硝基、氨基、酰氨基、烷基氨基、二烷基氨基、二烷基氨基烷基、氨基磺酰基、烷硫基、巯基、羟基、羟烷基、烷基磺酰基、卤素、氰基、羧基、羰基烷氧基、氨基甲酰基、卤代烷基或环烷氧基的一个或多个成员；和 R5 选自烷基亚磺酰基、烷基亚磺酰基或烷基磺酰基。
• Substituted indenyl compounds
  申请人：FGN, INC.

  公开号：EP0508586A1

  公开（公告）日：1992-10-14

  Substituted indenyl sulfonyl acetic acids are seful in the treatment of precancerous lesions.

  取代的茚磺酰基乙酸可用于治疗癌前病变。