1-(2,6-dimethylphenoxy)-N-ethylpropan-2-amine hydrochloride | 194027-12-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(2,6-dimethylphenoxy)-N-ethylpropan-2-amine hydrochloride
• 英文别名: [2-(2,6-Dimethylphenoxy)-1-methylethyl]-ethylamine hydrochloride salt；1-(2,6-dimethylphenoxy)-N-ethylpropan-2-amine;hydrochloride
• CAS: 194027-12-8
• 化学式: C₁₃H₂₁NO*ClH
• 分子量: 243.777
• InChiKey: JQXTVBRGJSIIJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  21.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(2,6-二甲基苯氧基)-2-丙酮 在 盐酸 、 sodium cyanoborohydride 作用下， 以 乙醚 、 乙醇 、 二氯甲烷 为溶剂， 反应 1.0h， 生成 1-(2,6-dimethylphenoxy)-N-ethylpropan-2-amine hydrochloride
  参考文献：
  名称：

  Antiarrhythmic Hit to Lead Refinement in a Dish Using Patient-Derived iPSC Cardiomyocytes

  摘要：

  DOI：

  10.1021/acs.jmedchem.0c01545

文献信息

• Treatment of neuropathic pain
  申请人：Syntex (U.S.A.) Inc.

  公开号：US05688830A1

  公开（公告）日：1997-11-18

  This invention relates to a compound of the Formula I: ##STR1## as a racemic mixture and its individual enantiomers, in particular the (R)-enantiomer, and their pharmaceutically acceptable salts. These compounds are useful as sodium channel blockers, and are particularly useful for the alleviation of neuropathic pain.

  这项发明涉及公式I的化合物：##STR1## 作为外消旋混合物及其单一对映体，特别是(R)-对映体，以及它们的药用盐。这些化合物可用作钠通道阻滞剂，特别适用于缓解神经病理性疼痛。
• AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS
  申请人：LICHTER Jay

  公开号：US20090306225A1

  公开（公告）日：2009-12-10

  Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

  本文公开了使用免疫调节剂和耳压调节剂治疗耳部疾病的组合物和方法。在这些方法中，通过将免疫调节剂和/或耳压调节剂组合物和配方直接应用于耳媒介和/或耳内靶区，或通过灌注进入耳媒介和/或耳内结构，局部给患有耳部疾病的个体进行治疗。
• Auris Formulations for Treating Otic Diseases and Conditions
  申请人：Otonomy, Inc.

  公开号：US20160228357A1

  公开（公告）日：2016-08-11

  Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

  本文介绍了使用免疫调节剂和耳压调节剂治疗耳部疾病的组合物和方法。在这些方法中，通过直接将免疫调节剂和/或耳压调节剂组合物和配方局部应用于患有耳部疾病的个体的耳媒体和/或耳内靶区，或通过灌注到耳媒体和/或耳内结构中。
• Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders
  申请人：Lichter Jay

  公开号：US10092580B2

  公开（公告）日：2018-10-09

  Disclosed herein are compositions and methods for the treatment of otic disorders with otic structure modulating compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).

  本文公开了用于治疗耳部疾病的组合物和方法，通过将这些组合物和成分直接施用到或通过灌注到目标虹膜结构，对患有耳部疾病的人局部施用调节耳部结构的组合物。
• Auris formulations for treating otic diseases and conditions
  申请人：Otonomy, Inc.

  公开号：US10272034B2

  公开（公告）日：2019-04-30

  Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

  本文公开了使用免疫调节剂和耳压调节剂治疗耳部疾病的组合物和方法。在这些方法中，通过将免疫调节剂和/或免疫调节压力调节剂组合物和制剂直接施用到耳道介质和/或耳道间质目标区域，或通过灌注到耳道介质和/或耳道间质结构中，对耳道疾病患者进行局部给药。