(E)-3-(4-(9H-carbazole-9-yl)phenyl)acrylic acid | 937269-50-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (E)-3-(4-(9H-carbazole-9-yl)phenyl)acrylic acid
• 英文别名: (E)-3-(4-(9H-carbazol-9-yl)phenyl)acrilic acid；(e)-3-(4-(9h-Carbazol-9-yl)phenyl) acrylic acid；(E)-3-(4-carbazol-9-ylphenyl)prop-2-enoic acid
• CAS: 937269-50-6
• 化学式: C₂₁H₁₅NO₂
• 分子量: 313.356
• InChiKey: OWCLDRMYOJGLMQ-SDNWHVSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-3-(4-(9H-carbazole-9-yl)phenyl)acrylic acid 、 二正丁基氧化锡 以 苯 为溶剂， 反应 24.0h， 以80%的产率得到{[n-Bu2SnO((E)-3-(4-(9H-carbazole-9-yl)phenyl)acrylato)]2O}2
  参考文献：
  名称：

  Synthesis, crystal structure, and in vitro antitumor activity of a novel tetranuclear Di-n-butyltin(IV)

  摘要：

  A di-n-butyltin(IV) complex with (E)-3-(4-(9H-carbazole-9-yl)phenyl) acrylic acid (HL) of the formula {[n-Bu2SnOL](2)O}(2) was synthesized and characterized by X-ray crystallography. This complex is a tetranuclear one with ladder framework. Furthermore, this complex was tested in vitro for its cytotoxic activity, using human hepatocellular carcinoma cell line (BEL-7402) and human hepatocellular liver carcinoma cell line (HepG2); 5-Fluorouracil was used as a positive control substance. This complex showed cytotoxicity greater than that of 5-Fluorouracil.

  DOI：

  10.1134/s1070328413070026

文献信息

• Synthesis, crystal structure and in vitro antibacterial activity of two novel silver(I) complexes
  作者：Banfeng Ruan、Yupeng Tian、Hongping Zhou、Jieying Wu、Zhaodi Liu、Chenhao Zhu、Jiaxiang Yang、Hailiang Zhu

  DOI：10.1016/j.jorganchem.2009.04.020

  日期：2009.8

  confirming that 1 is a binuclear complex whereas 2 is a tetranuclear one. Both complexes were assayed for antibacterial activity against two Gram-positive bacterial strains (Bacillus subtilis ATCC 6633 and Staphylococcus aureus ATCC 6538) and two Gram-negative bacterial strains (Pseudomonas aeruginosa ATCC 13525 and Escherichia coli ATCC 35218) by MTT method. Complex 2 exhibited powerful antibacterial activities

  两种银（I）络合物[Ag 2（dppm）2（L 1）2（CH 2 Cl 2）2 ]（1）和[Ag 4（dppm）2（L 2）2（NO 3）2 ]（2）是通过[Ag 2（dppm）2（NO 3）2 ]与HL 1和HL 2反应制备的[dppm =双（二苯基膦基）甲烷，HL 1  = 2-（9H-咔唑-9-基）乙酸和HL 2 ＝（E）-3-（4-（9H-咔唑-9-基）苯基）丙烯酸]。两种配合物的结构均已通过X射线晶体学表征，证实1是双核配合物，而2是四核配合物。通过MTT法测定两种复合物对两种革兰氏阳性细菌菌株（枯草芽孢杆菌ATCC 6633和金黄色葡萄球菌ATCC 6538）和两种革兰氏阴性细菌菌株（铜绿假单胞菌ATCC 13525和大肠杆菌ATCC 35218）的抗菌活性。复合物2对枯草芽孢杆菌具有强大的抗菌活性 ATCC 6633的MIC为0.78μg/ mL，优于阳性对照青霉素G。根据生物学结果，讨论了构效关系。