15-hydroxypentadecanal | 22054-18-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 15-hydroxypentadecanal
• 英文别名: 15-Hydroxypentadecanal
• CAS: 22054-18-8
• 化学式: C₁₅H₃₀O₂
• 分子量: 242.402
• InChiKey: UBRAGNSHRHJVCL-UHFFFAOYSA-N

物化性质

• 沸点：
  353.2±15.0 °C(Predicted)
• 密度：
  0.894±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  17
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  15-hydroxypentadecanal 在 cerium(III) chloride 、 三乙基硅基三氟甲磺酸酯 、 戴斯-马丁氧化剂 、 三苯基膦 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 2.0h， 生成 (3E,18E)-20-hydroxy-20-methylhenicosa-3,18-dien-2-one
  参考文献：
  名称：

  在烯酮存在下使用α，β-不饱和酯的高判别性双向转化法精确合成氧杂环化合物

  摘要：

  使用两种类型的phospho盐，在烯酮存在下对α，β-不饱和酯进行了高判别转化，并将其应用于一锅六步合成乙二环化合物。

  DOI：

  10.1039/c7cc03287k
• 作为产物：
  描述：

  环十五内酯 在 二异丁基氢化铝 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 2.0h， 生成 15-hydroxypentadecanal
  参考文献：
  名称：

  在烯酮存在下使用α，β-不饱和酯的高判别性双向转化法精确合成氧杂环化合物

  摘要：

  使用两种类型的phospho盐，在烯酮存在下对α，β-不饱和酯进行了高判别转化，并将其应用于一锅六步合成乙二环化合物。

  DOI：

  10.1039/c7cc03287k

文献信息

• METHODS AND MATERIALS FOR BIOSYNTHESIZING MULTIFUNCTIONAL, MULTIVARIATE MOLECULES VIA CARBON CHAIN MODIFICATION
  申请人：INVISTA NORTH AMERICA S.A.R.L.

  公开号：US20180023103A1

  公开（公告）日：2018-01-25

  This document describes biochemical pathways for producing a difunctional product having an odd number of carbon atoms in vitro or in a recombinant host, or salts or derivatives thereof, by forming two terminal functional groups selected from carboxyl, amine, formyl, and hydroxyl groups in an aliphatic carbon chain backbone having an odd number of carbon atoms synthesized from (i) acetyl-CoA and propanedioyl-CoA via one or more cycles of methyl ester shielded carbon chain elongation or (ii) propanedioyl-[acp] via one or more cycles of methyl ester shielded carbon chain elongation. The biochemical pathways and metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded aliphatic carbon chain backbones and maintaining the methyl ester shield for at least one further enzymatic step following one or more cycles of methyl ester shielded carbon chain elongation.

  本文档描述了在体外或在重组宿主中通过形成选择自羧基、胺基、甲酰基和羟基中的两个末端功能基团在具有奇数碳原子数量的脂肪碳链骨架中合成的具有双功能产品的生化途径，或其盐或衍生物，该脂肪碳链骨架是通过从（i）乙酰辅酶A和丙二酰辅酶A经过一个或多个甲酯屏蔽的碳链延长循环或（ii）丙二酰-[acp] 经过一个或多个甲酯屏蔽的碳链延长循环合成的奇数碳原子。本文中描述的生化途径、代谢工程和培养策略依赖于接受甲酯屏蔽脂肪碳链骨架并在一个或多个甲酯屏蔽的碳链延长循环之后至少保持甲酯屏蔽以进行至少一个进一步的酶催化步骤的酶或同源体。
• Methods and materials for biosynthesizing multifunctional, multivariate molecules via carbon chain modification
  申请人：INVISTA NORTH AMERICA S.A.R.L.

  公开号：US10801046B2

  公开（公告）日：2020-10-13

  This document describes biochemical pathways for producing a difunctional product having an odd number of carbon atoms in vitro or in a recombinant host, or salts or derivatives thereof, by forming two terminal functional groups selected from carboxyl, amine, formyl, and hydroxyl groups in an aliphatic carbon chain backbone having an odd number of carbon atoms synthesized from (i) acetyl-CoA and propanedioyl-CoA via one or more cycles of methyl ester shielded carbon chain elongation or (ii) propanedioyl-[acp] via one or more cycles of methyl ester shielded carbon chain elongation. The biochemical pathways and metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded aliphatic carbon chain backbones and maintaining the methyl ester shield for at least one further enzymatic step following one or more cycles of methyl ester shielded carbon chain elongation.

  本文件描述了在体外或重组宿主中生产具有奇数个碳原子的双官能团产物或其盐或衍生物的生化途径，其方法是在具有奇数个碳原子的脂肪族碳链骨架上形成两个末端官能团，这两个末端官能团选自羧基、胺、甲酰基和羟基、(i) 乙酰-CoA 和丙二酰-CoA 通过一次或多次循环的甲酯屏蔽碳链伸长或 (ii) 丙二酰-[acp]通过一次或多次循环的甲酯屏蔽碳链伸长合成的具有奇数个碳原子的脂肪族碳链骨架中的两个末端官能团。本文所述的生化途径和代谢工程及培养策略依赖于酶或同源物接受甲酯屏蔽的脂肪族碳链骨架，并在一个或多个甲酯屏蔽碳链伸长循环后维持甲酯屏蔽至少一个进一步的酶步骤。
• [EN] PEPTIDES FOR TREATMENT OF OBESITY<br/>[FR] PEPTIDES POUR LE TRAITEMENT DE L'OBÉSITÉ
  申请人：NOVO NORDISK AS

  公开号：WO2010060901A1

  公开（公告）日：2010-06-03

  The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of obesity as well as a variety of diseases or conditions associated with obesity.
• [EN] METHODS AND MATERIALS FOR BIOSYNTHESIZING MULTIFUNCTIONAL, MULTIVARIATE MOLECULES VIA CARBON CHAIN MODIFICATION<br/>[FR] PROCÉDÉS ET MATÉRIAUX POUR LA BIOSYNTHÈSE DE MOLÉCULES MULTIFONCTIONNELLES ET MULTIDIMENSIONELLES PAR MODIFICATION DE LA CHAÎNE CARBONÉE
  申请人：INVISTA TEXTILES (U K ) LTD

  公开号：WO2018022633A1

  公开（公告）日：2018-02-01

  This document describes biochemical pathways for producing a difunctional product having an odd number of carbon atoms in vitro or in a recombinant host, or salts or derivatives thereof, by forming two terminal functional groups selected from carboxyl, amine, formyl, and hydroxyl groups in an aliphatic carbon chain backbone having an odd number of carbon atoms synthesized from (i) acetyl-CoA and propanedioyl-CoA via one or more cycles of methyl ester shielded carbon chain elongation or (ii) propanedioyl-[acp] via one or more cycles of methyl ester shielded carbon chain elongation, The biochemical pathways and metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded aliphatic carbon chain backbones and maintaining the methyl ester shield for at least one further enzymatic step following one or more cycles of methyl ester shielded carbon chain elongation.
• Concise synthesis of oxacyclic compounds using highly discriminative two-way transformations of α,β-unsaturated esters in the presence of enones
  作者：Kenta Morita、Reiya Ohta、Hiroshi Aoyama、Kenzo Yahata、Mitsuhiro Arisawa、Hiromichi Fujioka

  DOI：10.1039/c7cc03287k

  日期：——

  Highly discriminative transformation of α,β-unsaturated esters in the presence of enones using two types of phosphonium salts, and their application to the synthesis of oxacyclic compounds in six steps in one pot have been achieved.

  使用两种类型的phospho盐，在烯酮存在下对α，β-不饱和酯进行了高判别转化，并将其应用于一锅六步合成乙二环化合物。