ethyl 2-cyano-2-methylcyclopropanecarboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 2-cyano-2-methylcyclopropanecarboxylate
• 英文别名: ethyl (1R,2R)-2-cyano-2-methylcyclopropanecarboxylate；ethyl (1R,2R)-2-cyano-2-methylcyclopropane-1-carboxylate
• 化学式: C₈H₁₁NO₂
• 分子量: 153.181
• InChiKey: RYOKVXOPSCPLNI-XPUUQOCRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  50.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  cis-tetracarbonylbis(piperidine)molybdenum 生成 ethyl 2-cyano-2-methylcyclopropanecarboxylate
  参考文献：
  名称：

  DOYLE, M. P.;DOROW, R. L.;TAMBLYN, W. H., J. ORG. CHEM., 1982, 47, N 21, 4059-4068

  摘要：

  DOI：

文献信息

• ASYMMETRIC CYCLOPROPANATION OF ELECTRON-DEFICIENT OLEFINS WITH DIAZO REAGENTS
  申请人：Zhang X. Peter

  公开号：US20100076239A1

  公开（公告）日：2010-03-25

  Cobalt-catalyzed asymmetric cyclopropanation of electron-deficient olefins.

  钴催化的电子不足烯烃不对称环丙烷化。
• Cyclopropanation of .alpha.,.beta.-unsaturated carbonyl compounds and nitriles with diazo compounds. The nature of the involvement of transition-metal promoters
  作者：Michael P. Doyle、Robert L. Dorow、William H. Tamblyn

  DOI：10.1021/jo00142a013

  日期：1982.10
• Cobalt-Catalyzed Asymmetric Cyclopropanation of Electron-Deficient Olefins
  作者：Ying Chen、Joshua V. Ruppel、X. Peter Zhang

  DOI：10.1021/ja074613o

  日期：2007.10.1

  The cobalt(II) complex of a D 2-Symmetric chiral porphyrin [Co(1)] is an effective catalyst for asymmetric cyclopropanation of electron-deficient olefins, including M,P-unsaturated esters, amides, ketones, and nitriles. Due to the absence of dimerization of diazo compounds, the catalytic reactions can be performed in one-pot protocol using olefins as the limiting reagent, forming the desired electrophilic cyclopropane derivatives in high yields and selectivities under mild conditions. In most cases, both excellent diastereo- and enantioselectivity were achieved.
• DOYLE, M. P.;DOROW, R. L.;TAMBLYN, W. H., J. ORG. CHEM., 1982, 47, N 21, 4059-4068
  作者：DOYLE, M. P.、DOROW, R. L.、TAMBLYN, W. H.

  DOI：——

  日期：——