bis(4-(bromomethyl)phenyl)sulfane | 90549-27-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: bis(4-(bromomethyl)phenyl)sulfane
• 英文别名: bis(4-(bromomethyl)phenyl)diphenyl sulfide；Bis(4-(bromomethyl)phenyl)sulfide；1-(bromomethyl)-4-[4-(bromomethyl)phenyl]sulfanylbenzene
• CAS: 90549-27-2
• 化学式: C₁₄H₁₂Br₂S
• 分子量: 372.123
• InChiKey: XRIRZXSWLAUWPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  bis(4-(bromomethyl)phenyl)sulfane 在 双氧水 作用下， 以 溶剂黄146 为溶剂， 以68%的产率得到1-(4-(溴甲基)苯基磺酰基)-4-(溴甲基)苯
  参考文献：
  名称：

  Donor−Acceptor−Donor Fluorene Derivatives for Two-Photon Fluorescence Lysosomal Imaging

  摘要：

  As part of a strategy to achieve large two-photon absorptivity in fluorene-based probes, a series of donor- acceptor-donor (D-A-D) type derivatives were synthesized and their two-photon absorption (2PA) properties investigated. The synthesis of D-A-D fluorophores was achieved by efficient preparation of key intermediates for the introduction of central electron acceptor groups. To accomplish the synthesis of two of the new derivatives, a high-yield method for a one-step direct dibromomethylation of phenyl sulfide was developed. The linear and nonlinear optical properties, including UV-vis absorption, fluorescence emission, fluorescence anisotropy, and two-photon absorption (2PA), of the new D-A-D compounds were measured and compared to their D-A or D-D counterparts. Fully conjugated acceptor moieties in the center of the D-A-D fluorophore led to the greatest increase in the 2PA cross section, while weakly conjugated central acceptors exhibited only a modest increase in the 2PA cross section relative to D-A diploar analogs. Encapsulation of the new probes in Pluronic F 108N F micelles, and subsequent incubation in HCT 116 cells, resulted in very high lysosomal colocalization (> 0.98 colocalization coefficient) relative to commercial Lysotracker Red, making the micelle-encapsulated dyes particularly attractive as fluorescent probes for two-photon fluorescence microscopy lysosomal imaging.

  DOI：

  10.1021/jo100554j
• 作为产物：
  描述：

  聚合甲醛 、 二苯硫醚 在 氢溴酸 作用下， 以 溶剂黄146 为溶剂， 反应 48.0h， 以77%的产率得到bis(4-(bromomethyl)phenyl)sulfane
  参考文献：
  名称：

  Donor−Acceptor−Donor Fluorene Derivatives for Two-Photon Fluorescence Lysosomal Imaging

  摘要：

  As part of a strategy to achieve large two-photon absorptivity in fluorene-based probes, a series of donor- acceptor-donor (D-A-D) type derivatives were synthesized and their two-photon absorption (2PA) properties investigated. The synthesis of D-A-D fluorophores was achieved by efficient preparation of key intermediates for the introduction of central electron acceptor groups. To accomplish the synthesis of two of the new derivatives, a high-yield method for a one-step direct dibromomethylation of phenyl sulfide was developed. The linear and nonlinear optical properties, including UV-vis absorption, fluorescence emission, fluorescence anisotropy, and two-photon absorption (2PA), of the new D-A-D compounds were measured and compared to their D-A or D-D counterparts. Fully conjugated acceptor moieties in the center of the D-A-D fluorophore led to the greatest increase in the 2PA cross section, while weakly conjugated central acceptors exhibited only a modest increase in the 2PA cross section relative to D-A diploar analogs. Encapsulation of the new probes in Pluronic F 108N F micelles, and subsequent incubation in HCT 116 cells, resulted in very high lysosomal colocalization (> 0.98 colocalization coefficient) relative to commercial Lysotracker Red, making the micelle-encapsulated dyes particularly attractive as fluorescent probes for two-photon fluorescence microscopy lysosomal imaging.

  DOI：

  10.1021/jo100554j

文献信息

• Counter-rotatable dual cinchona quinuclidinium salts and their phase transfer catalysis in enantioselective alkylation of glycine imines
  作者：Jiin Oh、Jihyeon Park、Keepyung Nahm

  DOI：10.1039/d1cc02785a

  日期：——

  Dual cinchona quinuclidinium salts with a diphenyl ether linker were synthesized and used as powerful asymmetric phase transfer catalysts in the α-alkylation of imines of glycine and alanine ester with 0.01–0.1 mol% loading (17 examples, 92–99% ee). Skewed conformers of dual quinuclidiniums at TS were proposed to rationalize their high efficiency via DFT calculations.

  合成了具有二苯醚接头的双金鸡纳奎宁鎓盐，并将其用作强大的不对称相转移催化剂，用于甘氨酸和丙氨酸酯亚胺的 α-烷基化，负载量为 0.01-0.1 mol%（17 个实例，92-99% ee）。提出了 TS 双 quinuclidinium 的倾斜构象异构体，以通过DFT 计算使其高效率合理化。
• NOVEL SULFUR COMPOUNDS AND PROCESS FOR PRODUCING THE SAME
  申请人：SUMITOMO SEIKA CHEMICALS CO., LTD.

  公开号：EP0791579A1

  公开（公告）日：1997-08-27

  A novel sulfur-containing compound represented by the general formula (I): wherein n is an integer from 0 to 2; R represents a hydrogen atom, a vinyl group, a methacryloyl group, a vinylbenzyl group, a glycidyl group, an acryloyl group or an allyl group; and the case where n is 0 and R is a hydrogen atom is excluded, and a method for preparing said sulfur-containing compound. The novel sulfur-containing compound of the present invention can be copolymerized with various copolymerizable compounds to yield excellent hardened products of high refractive index. The novel sulfur-containing compound of the present invention can therefore be used as a very useful monomer for the production of optical materials, paints, adhesives, sealants, etc. having excellent properties.

  一种通式(I)代表的新型含硫化合物： 其中 n 为 0 至 2 的整数；R 代表氢原子、乙烯基、甲基丙烯酰基、乙烯基苄基、缩水甘油基、丙烯酰基或烯丙基；不包括 n 为 0 和 R 为氢原子的情况，以及制备所述含硫化合物的方法。本发明的新型含硫化合物可与各种可共聚化合物共聚，从而得到高折射率的优良硬化产品。因此，本发明的新型含硫化合物可作为一种非常有用的单体，用于生产具有优异性能的光学材料、涂料、粘合剂、密封剂等。
• 一种金属超分子化合物在制备抗新冠病毒的药物中的应用
  申请人：中国科学院长春应用化学研究所

  公开号：CN117815397A

  公开（公告）日：2024-04-05

  本发明涉及金属超分子化合物在制备抗新冠病毒的药物中的应用，具体提供了手性金属超分子化合物在制备提高RNA G‑四链体的稳定性的制剂中的应用。本发明首先发现了通过金属超分子化合物Λ1金属配合物可以高度稳定SARS‑CoV‑2RNA G‑四链体，并有效抑制病毒蛋白的表达，从而根除SARS‑CoV‑2。然而，对相应对映体Δ1的金属配合物没有检测到明显的效果，显示出显著的对映选择性。更重要的是，Λ1金属配合物更倾向于SARS‑CoV‑2G‑四链体，而不是人类基因组中的各种DNA G‑四链体，这表明其具有治疗COVID‑19的潜力。
• 七核铜吡唑配合物及其制备方法和应用
  申请人：郑州师范学院

  公开号：CN117186122A

  公开（公告）日：2023-12-08

  本发明属于催化合成技术领域，特别涉及一种新型七核铜吡唑配合物及其制备和应用。所述新的金属配合物进一步地拓展了铜吡唑金属配合物在CO2催化领域的应用。其用于催化CO2与环氧化物的环加成反应，在常压下、65℃即可进行，反应条件温和；同时本发明配合物还具有良好的催化活性和宽泛的底物普适性。
• SULFUR COMPOUNDS AND PROCESS FOR PRODUCING THE SAME
  申请人：SUMITOMO SEIKA CHEMICALS CO., LTD.

  公开号：EP0791579B1

  公开（公告）日：2002-07-17