ethylene glycol monomethacrylate chloroformate | 13695-27-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethylene glycol monomethacrylate chloroformate
• 英文别名: 2-methyl-2-propenoic acid, 2-[(chlorocarbonyl)oxy]ethyl ester；2-Methacryloyloxyethyl chloroformate；2-carbonochloridoyloxyethyl 2-methylprop-2-enoate
• CAS: 13695-27-7
• 化学式: C₇H₉ClO₄
• 分子量: 192.599
• InChiKey: WNGWIBINRGUHSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2916140000

反应信息

• 作为反应物：
  描述：

  1,2-bis(hydroxymethyl)-ortho-carborane 、 ethylene glycol monomethacrylate chloroformate 在 triethylamine 作用下， 以 二氯甲烷 为溶剂， 以97%的产率得到1,2-di(hydroxymethyl)-ortho-dicarbaborane bis(methacryloyloxyethyl carbonate)
  参考文献：
  名称：

  Shashkova; Koval'chuk; Zapadinskii, Russian Journal of General Chemistry, 1999, vol. 69, # 2, p. 225 - 234

  摘要：

  DOI：
• 作为产物：
  描述：

  甲基丙烯酸羟乙酯 、 光气 在 三乙胺 作用下， 以 氯仿 为溶剂， 以82%的产率得到ethylene glycol monomethacrylate chloroformate
  参考文献：
  名称：

  Synthesis of 4-[N- [2-(Methacryloyloxy) Ethoxycarbonyl) ]Amino-N′-[2- (Diethylamino) Ethyl]Benzamide; A Novel Polymerizable Derivative of Procainamide

  摘要：

  DOI：

  10.1002/bscb.19840930211

文献信息

• Polymerizable carbonates having ethylenic and acetylenic functions
  申请人：Nippon Paint Company, Limited

  公开号：US05194655A1

  公开（公告）日：1993-03-16

  A carbonate compound having ethylenically unsaturated and acetylenically unsaturated functions are disclosed. The compound is represented by the formula: ##STR1## wherein, A is the residue of a hydroxy group-containing, ethylenically unsaturated monomer with removal of the hydroxyl group, R.sup.1 and R.sup.2 are independently a hydrogen atom or a C.sub.1 -C.sub.20 alkyl.

  公开了一种具有乙烯基不饱和和乙炔基不饱和功能的碳酸盐化合物。该化合物由以下式子表示：##STR1## 其中，A是含有羟基的乙烯基不饱和单体的残基，去除羟基后得到；R1和R2分别是氢原子或C1-C20烷基。
• TUNABLE, BIODEGRADABLE LINKER MOLECULES FOR TRANSIENT CONJUGATION OF COMPONENTS IN DRUG DELIVERY SYSTEMS, AND DRUG DELIVERY SYSTEMS PREPARED THEREWITH
  申请人：Rijcken Cristianne Johanna Ferdinand

  公开号：US20130261094A1

  公开（公告）日：2013-10-03

  The present invention relates to a particular class of biodegradable linkers, ensuring transiently stable conjugation of building blocks and/or bioactive compounds into drug delivery systems (DDS), such as DDS based on polymeric micelles or hydrogels. In addition, the present invention relates to compounds, comprising said linkers, such compounds preferably being prodrugs. Further, the invention is directed to the use of said linkers, and especially said biodegradable linkers, in a drug delivery system. Moreover, the invention relates to controlled release system comprising a polymer matrix, capable of releasing an active ingredient, wherein the active ingredient is covalently linked to the polymer molecules of the polymer matrix through said linkers, as well as to a method of synthesising these linkers and preparing such controlled release systems.

  本发明涉及一种特定类别的可生物降解连接剂，确保构建块和/或生物活性化合物短暂稳定地结合成药物传递系统（DDS），例如基于聚合物微粒或水凝胶的DDS。此外，本发明涉及包括所述连接剂的化合物，此类化合物优选为前药。此外，本发明还涉及所述连接剂的使用，特别是所述可生物降解连接剂在药物传递系统中的使用。此外，本发明还涉及控制释放系统，包括聚合物基质，能够释放活性成分，其中所述活性成分通过所述连接剂共价连接到聚合物基质的聚合物分子上，以及一种合成这些连接剂和制备此类控制释放系统的方法。
• Novel unsaturated peroxides, polymeric derived therefrom and their uses
  申请人：ELF ATOCHEM NORTH AMERICA, INC.

  公开号：EP0667339A1

  公开（公告）日：1995-08-16

  Novel unsaturated peroxide compositions of Structure A, are disclosed where the R-Q- grouping contains a polymerizable carbon-carbon double bound, i.e. R is, inter alia, alkyl of 1 to 18 carbons; Q is, inter alia, where -(X-Ri) shows the point of attachment of the X-R1 group and (R)- shows the point of attachment of the R group to the Q diradical and R2 and R3 include hydrogen; -X- includes a direct bond and -R1 is a peroxide-containing radical, e.g., wherein R6, R7, R8 and R9 are, inter alia, alkyl of 1 to 4 carbons and R10 includes t-alkyl of 4 to 12 carbons. Further, polymeric peroxide compositions derived from them and their uses are disclosed.

  公开了结构 A.的新型不饱和过氧化物组合物、 公开了结构 A 的新型不饱和过氧化物组合物，其中 R-Q-基团含有可聚合的碳碳双键，即 R 除其他外为 1 至 18 碳原子的烷基；Q 除其他外为 1 至 18 碳原子的烷基、 其中 -(X-Ri) 表示 X-R1 基团的连接点，(R)- 表示 R 基团与 Q 二叉基团的连接点，R2 和 R3 包括氢；-X- 包括直接键，-R1 是含过氧化物的基团，如 其中 R6、R7、R8 和 R9 除其他外为 1 至 4 个碳原子的烷基，R10 包括 4 至 12 个碳原子的 t-烷基。此外，还公开了由它们衍生的聚合物过氧化物组合物及其用途。
• Photographic element containing ultraviolet absorbing polymer
  申请人：EASTMAN KODAK COMPANY

  公开号：EP0773473A1

  公开（公告）日：1997-05-14

  This invention relates to a photographic element containing a polymeric ultraviolet absorbing polymer fromed from an ultraviolet absorbing monomer of formula (I): where X is a bivalent linking group, and Y contains an ethylenically unsaturated functional group.

  本发明涉及一种照相元件，它含有由式（I）紫外线吸收单体制成的紫外线吸收聚合物： 其中 X 为二价连接基团，Y 含有乙烯不饱和官能团。
• Sivergin; Yarygina, Russian Journal of Organic Chemistry, 1997, vol. 33, # 4, p. 464 - 466
  作者：Sivergin、Yarygina

  DOI：——

  日期：——