申请人:Alwyn Company, Inc.
公开号:US20030147968A1
公开(公告)日:2003-08-07
Allantoin-containing preparations are prepared in a form suitable for administration as gels and aerosols. In one embodiment of the aerosol formulation, an allantoin-containing composition comprises: (1) water; (2) allantoin in a therapeutically effective quantity; (3) an anionic ethoxylated surfactant; (4) lanolin oil; and (5) cod liver oil. The composition has a viscosity and surface tension in a range that allows the composition to be administered to the skin of a user as an aerosol by a mechanical spray pump. In another aspect of this invention, the allantoin-containing preparations are prepared in a form suitable for administration as gels. The compositions can be substantially anhydrous or can contain water. In one embodiment of the gel formation, an allantoin-containing composition comprises: (1) allantoin in a therapeutically effective quantity; (2) a complex comprising mineral oil and at least one hydrogenated alkylene copolymer; (3) lanolin oil; and (4) cod liver oil. The compositions can comprise other ingredients. Compositions according to the present invention are suitable for the treatment of a number of skin conditions or diseases characterized by ulceration, inflammation, or blistering of the skin, such as epidermolysis bullosa.
含有尿囊素的制剂以适合作为凝胶和气雾剂的形式制备。在气雾剂配方的一个实施例中,含有尿囊素的组合物包括:(1)水;(2)疗效有效量的尿囊素;(3)阴离子乙氧基化表面活性剂;(4)羊毛脂油;和(5)鱼肝油。该组合物具有粘度和表面张力范围,使得通过机械喷雾泵将组合物作为气雾施用到用户皮肤上。在这项发明的另一个方面,含有尿囊素的制剂以适合作为凝胶的形式制备。这些组合物可以是几乎无水的,也可以含水。在凝胶形成的一个实施例中,含有尿囊素的组合物包括:(1)疗效有效量的尿囊素;(2)包括矿物油和至少一种氢化烷烯共聚物的复合物;(3)羊毛脂油;和(4)鱼肝油。这些组合物可以包含其他成分。根据本发明的组合物适用于治疗一系列皮肤状况或疾病,其特征是皮肤溃疡、炎症或水疱,如表皮溶解性水疱症。