1-[(10-bromodecyl)oxy]-4-chloro-benzene | 75612-72-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-[(10-bromodecyl)oxy]-4-chloro-benzene
• 英文别名: 1-Bromo-10-(4-chlorophenoxy)-decane；1-(10-bromodecoxy)-4-chlorobenzene
• CAS: 75612-72-5
• 化学式: C₁₆H₂₄BrClO
• 分子量: 347.723
• InChiKey: NJTLYAWMBICLJY-UHFFFAOYSA-N

物化性质

• 沸点：
  400.7±15.0 °C(Predicted)
• 密度：
  1.211±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  19
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-[(10-bromodecyl)oxy]-4-chloro-benzene 以 甲醇 为溶剂， 反应 6.0h， 以38%的产率得到10-苯氧基癸基溴化物
  参考文献：
  名称：

  The mechanism of the photo-induced homolysis of aryl halides

  摘要：

  DOI：

  10.1016/s0040-4039(00)78642-4
• 作为产物：
  描述：

  1,10-二溴癸烷 、 对氯苯酚 在 sodium hydride 作用下， 以 乙醇 为溶剂， 以65%的产率得到1-[(10-bromodecyl)oxy]-4-chloro-benzene
  参考文献：
  名称：

  ω-Substituted alkyl carboxylic acids as antidiabetic and lipid-lowering agents

  摘要：

  In screening experiments certain omega-substituted alkyl carboxylic acids were found to produce an increase in insulin-stimulated C-14-acetate incorporation into triglycerides, which may indicate an improvement in the action of insulin. Antidiabetic and lipid-lowering properties in genetically diabetic ob/ob mice demonstrated the in vivo relevance of the insulin-potentiating effects seen in vitro. The chemical structures of the w-substituted alkyl carboxylic acids with insulin-potentiating effects correspond to the general formula ring-spacer-COOH. A close structure-activity relationship was observed. The most potent compound in ob/ob mice was 3e, which normalized blood glucose as well as hyperinsulinaemia and lowered serum triglycerides and cholesterol by 52% and 37%, respectively. On the basis of these results, omega-substituted alkyl carboxylic acids are interesting as a new class of oral antidiabetic agents with insulin-sensitizing and lipid-lowering activity. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(99)80029-4

文献信息

• 2,2-Dichloroalkanecarboxylic acids, processes for their production and
  申请人：Roche Diagnostics GmbH

  公开号：US05968982A1

  公开（公告）日：1999-10-19

  Pharmaceutical agents for treating diabetus mellitus which contain a compound of formula I ##STR1## as the active substance, in which A, B, A' and W have the meanings stated in the claims, new compounds of formula I as well as processes for their production.

  治疗糖尿病的药物剂量，其含有公式I中的化合物作为活性物质，其中A，B，A'和W具有声明中所述的含义，公式I的新化合物以及其制备过程。
• Aryloxyalkylamine, Verfahren zu ihrer Herstellung und ihre Verwendung zur Bekämpfung unerwünschten Pflanzenwuchses
  申请人：BASF Aktiengesellschaft

  公开号：EP0103252A2

  公开（公告）日：1984-03-21

  Die Erfindung betrifft Aryloxyalkylamine der Formel in der Y, m. n. R1 und R2 die in der Beschreibung genannten Bedeutungen haben. Verfahren zu ihrer Herstellung und ihre Verwendung zur Bekämpfung unerwünschten Pflanzenwuchses.

  本发明涉及式如下的芳氧基烷基胺 其中 Y、m.n. R1 和 R2 具有说明中给出的含义。其制备工艺及其在防治植物不良生长方面的用途。
• 2,2-DICHLORALKANCARBONSÄUREN, VERFAHREN ZU IHRER HERSTELLUNG DIESE ENTHALTENDE ARZNEIMITTEL, UND IHRE VERWENDUNG ZUR BEHANDLUNG DER INSULINRESISTENZ
  申请人：Roche Diagnostics GmbH

  公开号：EP0790824B1

  公开（公告）日：2002-02-06
• US5968982A
  申请人：——

  公开号：US5968982A

  公开（公告）日：1999-10-19
• ω-Substituted alkyl carboxylic acids as antidiabetic and lipid-lowering agents
  作者：Kirstin Meyer、Edgar Voss、Richard Neidlein、Hans-Frieder Kühnle、Johannes Pill

  DOI：10.1016/s0223-5234(99)80029-4

  日期：1998.10

  In screening experiments certain omega-substituted alkyl carboxylic acids were found to produce an increase in insulin-stimulated C-14-acetate incorporation into triglycerides, which may indicate an improvement in the action of insulin. Antidiabetic and lipid-lowering properties in genetically diabetic ob/ob mice demonstrated the in vivo relevance of the insulin-potentiating effects seen in vitro. The chemical structures of the w-substituted alkyl carboxylic acids with insulin-potentiating effects correspond to the general formula ring-spacer-COOH. A close structure-activity relationship was observed. The most potent compound in ob/ob mice was 3e, which normalized blood glucose as well as hyperinsulinaemia and lowered serum triglycerides and cholesterol by 52% and 37%, respectively. On the basis of these results, omega-substituted alkyl carboxylic acids are interesting as a new class of oral antidiabetic agents with insulin-sensitizing and lipid-lowering activity. (C) Elsevier, Paris.