(1S,2S,13R,21R)-N-(4-aminobutyl)-22-(cyclopropylmethyl)-2,16-dihydroxy-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaene-7-carboxamide | 873428-01-4

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: (1S,2S,13R,21R)-N-(4-aminobutyl)-22-(cyclopropylmethyl)-2,16-dihydroxy-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaene-7-carboxamide
• CAS: 873428-01-4
• 化学式: C₃₁H₃₆N₄O₄
• 分子量: 528.651
• InChiKey: AZVWXRQRKHTUDB-FSYRHIKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  39
• 可旋转键数：
  7
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  124
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (1S,2S,13R,21R)-N-(4-aminobutyl)-22-(cyclopropylmethyl)-2,16-dihydroxy-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaene-7-carboxamide 、 丁二酸酐 在 三乙胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 0.5h， 生成
  参考文献：
  名称：

  Affinity identification of δ-opioid receptors using latex nanoparticles

  摘要：

  Three types of latex nanoparticles carrying naltrindole (NTI) derivatives were synthesized as probes for the affinity isolation of their binding proteins including the delta-opioid receptor. The effect of the attachment of NTI to different positions on the linker was investigated. Only latex nanoparticles in which the NTI derivative was linked through the phenol group were useful for isolating the recombinant delta-opioid receptor solubilized from CHO cell membrane. These latex nanoparticles could be a useful tool for investigations of the pharmacological activity of NTI. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.09.028
• 作为产物：
  描述：

  纳曲酮 在 4-(4-formyl-3-methoxyphenoxy)butyrylaminomethylpolystyrene 、 sodium cyanoborohydride 、 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 105.5h， 生成 (1S,2S,13R,21R)-N-(4-aminobutyl)-22-(cyclopropylmethyl)-2,16-dihydroxy-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaene-7-carboxamide
  参考文献：
  名称：

  Affinity identification of δ-opioid receptors using latex nanoparticles

  摘要：

  Three types of latex nanoparticles carrying naltrindole (NTI) derivatives were synthesized as probes for the affinity isolation of their binding proteins including the delta-opioid receptor. The effect of the attachment of NTI to different positions on the linker was investigated. Only latex nanoparticles in which the NTI derivative was linked through the phenol group were useful for isolating the recombinant delta-opioid receptor solubilized from CHO cell membrane. These latex nanoparticles could be a useful tool for investigations of the pharmacological activity of NTI. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.09.028

文献信息

• Affinity identification of δ-opioid receptors using latex nanoparticles
  作者：Makoto Hasegawa、Hiroshi Ohno、Hiroshi Tanaka、Mamoru Hatakeyama、Haruma Kawaguchi、Takashi Takahashi、Hiroshi Handa

  DOI：10.1016/j.bmcl.2005.09.028

  日期：2006.1

  Three types of latex nanoparticles carrying naltrindole (NTI) derivatives were synthesized as probes for the affinity isolation of their binding proteins including the delta-opioid receptor. The effect of the attachment of NTI to different positions on the linker was investigated. Only latex nanoparticles in which the NTI derivative was linked through the phenol group were useful for isolating the recombinant delta-opioid receptor solubilized from CHO cell membrane. These latex nanoparticles could be a useful tool for investigations of the pharmacological activity of NTI. (c) 2005 Elsevier Ltd. All rights reserved.