(2-Fluorophenyl)-(4-methoxyphenyl)methanol | 944695-91-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-Fluorophenyl)-(4-methoxyphenyl)methanol
• CAS: 944695-91-4
• 化学式: C₁₄H₁₃FO₂
• 分子量: 232.254
• InChiKey: AVOGIJRVHPNHGD-UHFFFAOYSA-N

物化性质

• 沸点：
  358.7±37.0 °C(Predicted)
• 密度：
  1.189±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-Fluorophenyl)-(4-methoxyphenyl)methanol 在 三乙胺 、 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 生成 2-氟-4’-甲氧基苯甲酮
  参考文献：
  名称：

  钯催化脱氢环化反应合成芴酮衍生物

  摘要：

  据报道，钯通过氧化脱氢环化反应将苯甲酮的双CH官能化形成芴酮。该方法为合成芴酮衍生物提供了一条简洁有效的途径，该途径显示出出色的官能团相容性。

  DOI：

  10.1021/ol302181z
• 作为产物：
  描述：

  4-溴苯甲醚 、 2-氟苯甲醛 在 magnesium 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 (2-Fluorophenyl)-(4-methoxyphenyl)methanol
  参考文献：
  名称：

  钯催化脱氢环化反应合成芴酮衍生物

  摘要：

  据报道，钯通过氧化脱氢环化反应将苯甲酮的双CH官能化形成芴酮。该方法为合成芴酮衍生物提供了一条简洁有效的途径，该途径显示出出色的官能团相容性。

  DOI：

  10.1021/ol302181z

文献信息

• Fe(OTf)₃-Catalyzed α-Benzylation of Aryl Methyl Ketones with Electrophilic Secondary and Aryl Alcohols
  作者：Xiaojuan Pan、Minghao Li、Yanlong Gu

  DOI：10.1002/asia.201300956

  日期：2014.1

  alcohols, is known to be an effective CC bond forming reaction. However, until now, this reaction has not been amenable for α‐alkylation of aryl methyl ketones because of the notoriously low nucleophilicities of these compounds. Therefore, α‐alkylation of aryl methyl ketone relies on precious metal catalysts and also, the use of primary alcohols is mandatory. In this study, we found that a system composed

  用亲电子醇将酸催化1，3-二羰基化合物的Friedel-Crafts烷基化反应是有效的CC键形成反应。但是，到目前为止，由于这些化合物的亲核性极低，因此该反应不适用于芳基甲基酮的α-烷基化。因此，芳基甲基酮的α-烷基化依赖于贵金属催化剂，而且必须使用伯醇。在这项研究中，我们发现一个由Fe（OTf）3组成的系统催化剂和氯苯溶剂足以通过使用苯氢酚作为亲电试剂来促进标题Friedel-Crafts反应。3,4-二氢-9-（2-羟基-4,4-二甲基-6-氧代-1-环己烯-1-基）-3,3-二甲基黄嘌呤-1（2 H）也适用在这种类型的苄基化反应中作为亲电试剂。基于此结果，还开发了水杨醛，二甲酮和芳基甲基酮的三组分反应，这为合成密集取代的4H-色烯衍生物提供了一种有效的方法。
• Brønsted Acid Ionic Liquid as a Solvent-Conserving Catalyst for Organic Reactions
  作者：Amir Taheri、Xiaojuan Pan、Changhui Liu、Yanlong Gu

  DOI：10.1002/cssc.201402220

  日期：2014.8

  sulfonyl‐containing ammonium‐based Brønsted acid ionic liquid was prepared and used as a liquid heterogeneous catalyst for organic reactions. The unique macroscopic phase heterogeneity of the IL in the reaction system not only ensures an excellent catalytic activity of the IL catalyst but also avoids the use of organic reaction solvents. The catalyst system is applicable for a wide range of reactions.

  制备了含磺酰基的铵基布朗斯台德酸离子液体，并将其用作有机反应的液体多相催化剂。IL在反应体系中独特的宏观相异质性不仅确保了IL催化剂的出色催化活性，而且避免了使用有机反应溶剂。催化剂体系适用于多种反应。
• Elemental step thermodynamics of various analogues of indazolium alkaloids to obtaining hydride in acetonitrile
  作者：Nan-Ping Lei、Yan-Hua Fu、Xiao-Qing Zhu

  DOI：10.1039/c5ob01715g

  日期：——

  A series of analogues of the natural indazolium alkaloids were designed and synthesized. The thermodynamic driving forces of the 6 elemental steps for the analogues to gain hydride in acetonitrile were determined. The reduction mechanism of indazolium alkaloids by NADH coenzyme was examined.

  一系列类似天然吲哚盐类生物碱的类似物被设计并合成。确定了类似物在乙腈中获得氢化物的6个基本步骤的热力学驱动力。研究了NADH辅酶对吲哚盐类生物碱的还原机制。
• Silica-supported policresulen as a solid acid catalyst for organic reactions
  作者：Kexing Zeng、Zhipeng Huang、Jie Yang、Yanlong Gu

  DOI：10.1016/s1872-2067(15)60910-x

  日期：2015.9

  A new type of solid catalyst was prepared by coating a thin layer of policresulen, an inexpensive polymer prepared via condensation of 2-hydroxy-4-methylbenzenesulfonic acid and formaldehyde that has been used as commercially available drug, onto the surface of silica. The policresulen component is insoluble in many organic solvents and can be adsorbed on silica with the aid of hydrogen bonding. The obtained silica/policresulen composite showed remarkable catalytic activity for various organic reactions. In model reactions, the catalyst can be recycled several times without significant loss of activity. The salient features of using this acid catalyst in organic reactions include cost-effectiveness, simple and time-efficient preparation, and the convenience of controlling the acid loading on the solid. (C) 2015, Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.
• Synthesis of Fluorenone Derivatives through Pd-Catalyzed Dehydrogenative Cyclization
  作者：Hu Li、Ru-Yi Zhu、Wen-Juan Shi、Ke-Han He、Zhang-Jie Shi

  DOI：10.1021/ol302181z

  日期：2012.9.21

  Palladium-catalyzed dual C–H functionalization of benzophenones to form fluorenones by oxidative dehydrogenative cyclization is reported. This method provides a concise and effective route toward the synthesis of fluorenone derivatives, which shows outstanding functional group compatibility.

  据报道，钯通过氧化脱氢环化反应将苯甲酮的双CH官能化形成芴酮。该方法为合成芴酮衍生物提供了一条简洁有效的途径，该途径显示出出色的官能团相容性。