[5-chloro-2-(2,4-dichlorophenoxy) phenoxy]-acetic acid methyl ester | 70007-07-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [5-chloro-2-(2,4-dichlorophenoxy) phenoxy]-acetic acid methyl ester
• 英文别名: Methyl 2-[5-chloro-2-(2,4-dichlorophenoxy)phenoxy]acetate
• CAS: 70007-07-7
• 化学式: C₁₅H₁₁Cl₃O₄
• 分子量: 361.609
• InChiKey: UVUSQYSQLHVUCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [5-chloro-2-(2,4-dichlorophenoxy) phenoxy]-acetic acid methyl ester 在 三乙胺 、 sodium hydroxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 [5-chloro-2-(2,4-dichloro-phenoxy)-phenoxy]-acetic acid methoxy carbonyl methyl ester
  参考文献：
  名称：

  Functionalized biodegradable triclosan monomers and oligomers for controlled release

  摘要：

  这项发明涉及发现功能化三氯生脂单体和寡聚体，当它们被纳入医疗设备或作为涂层的一部分应用于医疗设备和/或消费品时，可以延长医疗设备和/或消费品的抗菌性能持续时间。

  公开号：

  US08053591B2
• 作为产物：
  描述：

  三氯生 、 alkaline earth salt of/the/ methylsulfuric acid 生成 [5-chloro-2-(2,4-dichlorophenoxy) phenoxy]-acetic acid methyl ester
  参考文献：
  名称：

  DE2832435

  摘要：

  公开号：

文献信息

• Synthesis and herbicidal activities of aryloxyacetic acid derivatives as HPPD inhibitors
  作者：Man-Man Wang、Hao Huang、Lei Shu、Jian-Min Liu、Jian-Qiu Zhang、Yi-Le Yan、Da-Yong Zhang

  DOI：10.3762/bjoc.16.25

  日期：——

  (Ki = 0.011 µM) and I23 (Ki = 0.012 µM), which exhibit similar activities to that of mesotrione, a commercial HPPD herbicide (Ki = 0.013 µM). Furthermore, the newly synthesized compounds show significant greenhouse herbicidal activities against tested weeds at dosages of 150 g ai/ha. In particular, II4 exhibited high herbicidal activity for pre-emergence treatment that was slightly better than that

  设计并合成了一系列芳氧基乙酸衍生物，作为4-羟基苯基丙酮酸双加氧酶（HPPD）抑制剂。初步的生物测定结果表明，这些衍生物是有前途的拟南芥HPPD（At HPPD）抑制剂，特别是化合物I12（K i = 0.011 µM）和I23（K i = 0.012 µM），其活性与市售甲基磺草酮相似。 HPPD除草剂（K i = 0.013 µM）。此外，新合成的化合物在150 g ai / ha的剂量下对被测杂草显示出显着的温室除草活性。特别是II4在芽前处理中表现出较高的除草活性，略高于甲基磺草酮。此外，化合物II4对于玉米田中150 g ai / ha的杂草防治是安全的，并且被确定为新型HPPD抑制剂除草剂的最有效候选者。本文所述的化合物可为设计新的抑制HPPD的除草剂及其修饰提供有用的指导。
• FUNCTIONALIZED BIODEGRADABLE TRICLOSAN MONOMERS AND OLIGOMERS FOR CONTROLLED RELEASE
  申请人：Bezwada Rao S.

  公开号：US20090105352A1

  公开（公告）日：2009-04-23

  This invention relates to the discovery of functionalized triclosan monomers and oligomers that, when incorporated into a substrate of, or applied as part of a coating to, medical devices and/or consumer products may extend the duration of antimicrobial properties to the medical devices and/or consumer products.

  这项发明涉及发现的功能化三氯生单体和寡聚体，当它们被纳入医疗设备的基质中，或作为涂层的一部分应用于医疗设备和/或消费品时，可以延长医疗设备和/或消费品的抗菌性能持续时间。
• Selective Enzyme-Linked Immunosorbent Assay for Triclosan. Application to Wastewater Treatment Plant Effluents
  作者：Eva M. Brun、Emilio Bonet、Rosa Puchades、Ángel Maquieira

  DOI：10.1021/es702300s

  日期：2008.3.1

  A sensitive and highly selective enzyme-linked immunosorbent assay was developed for triclosan, one of the most common bactericides in personal care products, which is also considered as an emerging contaminant, given its presence in the effluents of sewage and wastewater treatment plants. From synthesized haptens, polyclonal rabbit antibodies against triclosan were raised. The best ELISA immunoassay was based on an antibody-coated format, yielding a detection limit of 0.03 mu g L-1, an l(50) of 3.85 mu g L-1, and a dynamic range from 0.22 to 42.16 mu g L-1, with little or no cross-reactivity (< 10%) to similarly structured compounds, including its metabolite methyltriclosan (CR < 6%). The assay was applied as a screening method to quantify triclosan in surface water and in wastewaters. After C18 solid-phase extraction, nanogram per liter concentrations were determined in effluents of urban wastewater treatment plants. The satisfactory recoveries achieved as well as the agreement between immunochemical and chromatographic methods (GC-MS) indicate its potential for either screening or laboratory quantification.
• US8053591B2
  申请人：——

  公开号：US8053591B2

  公开（公告）日：2011-11-08
• US8232422B2
  申请人：——

  公开号：US8232422B2

  公开（公告）日：2012-07-31