2-(diphenylhydroxymethyl)-1-methyl-1H-imidazole | 30517-58-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(diphenylhydroxymethyl)-1-methyl-1H-imidazole
• 英文别名: (1-methyl-1H-imidazol-2-yl)diphenylmethanol；2-(hydroxydiphenylmethyl)-1-methylimidazole；(1-methylimidazol-2-yl)diphenylmethanol；1-methylimidazol-2-diphenylmethanol；(1-methyl-1H-imidazol-2-yl)-diphenyl-methanol；mimCPh2OH；(1-Methylimidazol-2-yl)-diphenylmethanol
• CAS: 30517-58-9
• 化学式: C₁₇H₁₆N₂O
• 分子量: 264.327
• InChiKey: JTSGTMXVIOGSKF-UHFFFAOYSA-N

物化性质

• 溶解度：
  35.4 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  38
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(diphenylhydroxymethyl)-1-methyl-1H-imidazole 在 次氯酸 作用下， 生成 二苯甲酮
  参考文献：
  名称：

  1-甲基-1H-咪唑-2-YL部分对羰基的功能掩盖

  摘要：

  容易获得的1-甲基-2-（1'-羟烷基）-1H-咪唑（4）被发现是一种新型的羰基掩蔽形式，可以在各种恶劣条件下生存。通过用CH 3 I对咪唑（4）进行季铵化，然后进行碱性水溶液处理，可以容易地复制相应的羰基化合物（3）。通过使用本发明的方法，可以将2-酰基-1H-咪唑（5）转化为醛或酮（3）。

  DOI：

  10.1016/s0040-4039(01)91023-8
• 作为产物：
  描述：

  N-甲基咪唑 在 正丁基锂 作用下， 生成 2-(diphenylhydroxymethyl)-1-methyl-1H-imidazole
  参考文献：
  名称：

  The Metalation of 1-Methyl-, 1-Benzyl- and 1-Phenylimidazole with n-Butyllithium

  摘要：

  DOI：

  10.1021/ja01575a027

文献信息

• 1,2-Functionalized Imidazoles as Palladium Ligands: An Efficient and Robust Catalytic System for the Fluorine-Free Hiyama Reaction
  作者：Regina Martínez、Isidro M. Pastor、Miguel Yus

  DOI：10.1002/ejoc.201301439

  日期：2014.2

  Financial support from the Spanish Ministerio de Ciencia e Innovacion (MICINN) (project numbers CTQ2007-65218, CTQ2011-24165), from Consolider Ingenio 2010 (CSD2007-00006), from the Generalitat Valenciana (PROMETEO/2009/039), from the Fondos Europeos para el Desarrollo Regional (FEDER) and from the Universidad de Alicante is acknowledged.

  来自西班牙国家科学与创新部长 (MICINN)（项目编号 CTQ2007-65218、CTQ2011-24165）、Consolider Ingenio 2010 (CSD2007-00006)、瓦伦西亚政府总署 (PROMETEO/2009)、Fo Europeos para el Desarrollo Regional (FEDER) 和来自阿利坎特大学的认可。
• Isoprene-catalyzed lithiation of imidazole: synthesis of 2-(hydroxyalkyl)- and 2-(aminoalkyl)imidazoles
  作者：Rosario Torregrosa、Isidro M. Pastor、Miguel Yus

  DOI：10.1016/j.tet.2005.09.024

  日期：2005.11

  of isoprene (20 mol%) in THF at room temperature. By reacting this organolithium with carbonyl electrophiles 2-(hydroxyalkyl)imidazoles 3 were obtained, in good yields. As a result of the reaction of the mentioned lithium intermediate with imines 4, the corresponding 2-(aminoalkyl)imidazoles 5 were isolated in excellent yields.

  通过新方案制备2-锂硫代咪唑，该新方案由在室温下在THF中亚化学计量的异戊二烯（20摩尔％）存在下略有过量的锂金属组成。通过使该有机锂与羰基亲电试剂反应，以良好的产率获得了2-（羟烷基）咪唑3。作为上述锂中间体与亚胺4反应的结果，以优异的产率分离了相应的2-（氨基烷基）咪唑5。
• Ohta, Shunsaku; Hayakawa, Satoshi; Nishimura, Kazuko, Chemical and pharmaceutical bulletin, 1987, vol. 35, # 3, p. 1058 - 1069
  作者：Ohta, Shunsaku、Hayakawa, Satoshi、Nishimura, Kazuko、Okamoto, Masao

  DOI：——

  日期：——
• Carpenter, Andrew J.; Chadwick, Derek J.; Ngochindo Raphael I., Journal of Chemical Research, Miniprint, 1983, # 8, p. 1913 - 1941
  作者：Carpenter, Andrew J.、Chadwick, Derek J.、Ngochindo Raphael I.

  DOI：——

  日期：——
• Synthesis of nickel(II) complexes containing neutral N,N− and anionic N,O− bidentate ligands, and their behaviour as chain-growth catalysts; structural characterisation of complexes containing (mim)2CO, , and mimCPh2O− (mim=1-methylimidazol-2-yl)
  作者：Michael P. Batten、Allan J. Canty、Kingsley J. Cavell、Thomas Rüther、Brian W. Skelton、Allan H. White

  DOI：10.1016/j.ica.2004.06.069

  日期：2006.4

  The complexes NiBr2(L-2) [L-2 = (mim)(2)CO (7a), (bim)(2)CO (7b), py(mim)CO (8), PhN=CHbim (9)], NiBr(o-Tol)(mim)(2)CO) (10), Ni(L-2)(o-Tol)(PPh3) [L-2 = mimCO(2)(-) (11a), bmCO(2)(-)(11b), mimCPh(2)O(-) (12), mimC(6)H(4)O(-) (13)], and [Nif(MiM)2C0h1[BF412.0.25H,O (16) have been synthesised from nickel(II) salts (7-9, 16) or NiBr(o-Tol)(PPh3)(2) [10-13], where mim = 1-methylimidazol-2-yl, bim = 1-benzylimidazol-2-yl, and py = pyridin-2-yl. The square-planar complexes (11a, 12) and octahedral 16 have been characterised by X-ray diffraction studies, together with octahedral cis-[Ni(mim)(2)CO)(2)Br(OH2)](BrCD3CN)-C-. (14) and cis-[Ni(mim)(2)CO}(2)(OH2)(2)Br(2)(.)3CD(3)CN (15). Preliminary catalytic studies have been undertaken with a number of the nickel complexes. Complexes 11-13 form single component catalysts for the oligomerization or polymerization of ethylene and the bromo-complexes (7-9) form active catalysts for the oligomerization or polymerization of ethylene when activated with MMAO. (c) 2004 Elsevier B.V. All rights reserved.