cholinium serinate | 1361335-80-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cholinium serinate
• 英文别名: (2S)-2-amino-3-hydroxypropanoate;2-hydroxyethyl(trimethyl)azanium
• CAS: 1361335-80-9
• 化学式: C₃H₆NO₃*C₅H₁₄NO
• 分子量: 208.258
• InChiKey: TWEQFZNNFJIALY-WNQIDUERSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.26
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  氯化胆碱 在 potassium hydroxide 作用下， 以 甲醇 为溶剂， 生成 cholinium serinate
  参考文献：
  名称：

  源自生物可再生来源的双功能离子液体，可作为可持续固定二氧化碳的催化剂

  摘要：

  分别从胆碱和氨基酸制备了一系列含有季烷基铵阳离子和胺阴离子的高效双功能离子液体。合成，表征了九种IL，并将其用作有机催化剂以化学固定二氧化碳以形成环状碳酸酯和喹唑啉-2,4（1  H，3  H）-diones。IL和助催化剂的二元混合物会生成深共熔溶剂（DESs），并在大气压和低温（70°C）下加速环加成反应的速率。IL中胆碱的羟基官能团和氨基酸的游离胺基的存在对环氧化物和二氧化碳向环加成反应的活化具有协同作用。这些白介素是可生物降解的，并且是从易于获得的生物可再生来源合成的。此外，由于温和的无金属和无溶剂条件以及催化剂和助催化剂的可回收性，该催化方法显示出最终的环境友好性。

  DOI：

  10.1002/cssc.201601228

文献信息

• Choline and amino acid based biocompatible ionic liquid mediated transdermal delivery of the sparingly soluble drug acyclovir
  作者：Md. Rafiqul Islam、Md. Raihan Chowdhury、Rie Wakabayashi、Yoshiro Tahara、Noriho Kamiya、Muhammad Moniruzzaman、Masahiro Goto

  DOI：10.1016/j.ijpharm.2020.119335

  日期：2020.5

  Transdermal delivery of drugs is more challenging for drugs that are insoluble or sparingly soluble in water and most organic solvents. To overcome this problem, ionic liquid (IL)-mediated ternary systems have been suggested as potential drug carriers. Here, we report potent ternary (IL-EtOH-IPM) systems consisting of biocompatible ILs, ethanol (EtOH), and isopropyl myristate (IPM) that can dissolve

  对于不溶于水或微溶于水和大多数有机溶剂的药物，透皮给药更具挑战性。为了克服这个问题，已经提出离子液体（IL）介导的三元系统作为潜在的药物载体。在这里，我们报告了由生物相容性IL，乙醇（EtOH）和肉豆蔻酸异丙酯（IPM）组成的有效三元（IL-EtOH-IPM）系统，该系统可以溶解大量微溶性药物阿昔洛韦（ACV）。三元体系是光学透明的并且热力学稳定，具有广泛的IL相关性。一项体外药物渗透研究表明，三元系统中的IL大大增强了ACV渗透进皮肤和穿过皮肤的能力。用三元体系处理后的角质层（sc）的傅立叶变换红外光谱显示，皮肤屏障功能由于角质细胞规则排列的紊乱和渗透过程中sc的表面性质的改变而降低。组织学分析和使用重建的人表皮模型的皮肤刺激性研究显示了三元系统的安全性，并且皮，表皮和真皮的结构没有明显变化。因此，含有生物相容性IL的三元系统有望用于不溶性或微溶性药物的透皮递送。使用重建的人类表皮模型进
• Cholinium-amino acid based ionic liquids: a new method of synthesis and physico-chemical characterization
  作者：Serena De Santis、Giancarlo Masci、Francesco Casciotta、Ruggero Caminiti、Eleonora Scarpellini、Marco Campetella、Lorenzo Gontrani

  DOI：10.1039/c5cp01612f

  日期：——

  Fourteen cholinium-amino acid based room temperature ionic liquids were prepared using a cleaner synthetic method. Chemicophysical properties were well correlated with the wide range of amino acid chemical structures.

  使用更清洁的合成方法制备了十四种基于氨基酸的胆碱盐室温离子液体。化学物理性质与多样的氨基酸化学结构广泛相关。
• Ionic liquids from renewable biomaterials: synthesis, characterization and application in the pretreatment of biomass
  作者：Qiu-Ping Liu、Xue-Dan Hou、Ning Li、Min-Hua Zong

  DOI：10.1039/c2gc16128a

  日期：——

  A series of room temperature ionic liquids (ILs), in which cholinium acts as the cation and amino acids as the anions, were prepared via a simple and green chemical route, and characterized. Most of the ILs dissolved lignin efficiently and selectively (with solubilities of 140–220 mg of lignin per g of IL). The solubility of xylan in these ILs (which ranged from <1 to 85 mg g−1) depended on the nature of the anion, while cellulose was scarcely soluble (<5 mg g−1). In addition, enzymatic hydrolysis of microcrystalline cellulose and rice straw was enhanced significantly after pretreatment using the IL [Ch][Gly].

  一系列室温离子液体（ILs）被制备，其中胆碱作为阳离子，氨基酸作为阴离子，通过一种简单且环保的化学路线进行制备和表征。大多数ILs能够高效且选择性地溶解木质素（溶解度为每克IL 140–220毫克木质素）。这些ILs中木聚糖的溶解度（范围为<1到85毫克每克）依赖于阴离子的性质，而纤维素几乎不溶解（<5毫克每克）。此外，经过IL [Ch][Gly] 预处理后，微晶纤维素和稻草的酶解水解显著增强。
• Synthesis and Thermophysical Properties of Biocompatible Cholinium-Based Amino Acid Ionic Liquids
  作者：Duan-Jian Tao、Zheng Cheng、Feng-Feng Chen、Zhang-Min Li、Na Hu、Xiang-Shu Chen

  DOI：10.1021/je301103d

  日期：2013.6.13

  Nowadays the knowledge of thermodynamic properties for amino acid ionic liquids (AAILs) has been paramount for the design of many chemical processes. In this present work, a series of cholinium-based AAILs ([Ch][AA]) were synthesized by neutralization of choline hydroxide solution with five amino acids and then were characterized by H-1 NMR, Fourier transform infrared (FT-IR), elemental analysis, thermogravimetry, and differential scanning calorimetry (DSC) analysis. Physico-chemical properties such as density, viscosity, refractive index, and conductivity were measured and correlated with the empirical equations in a wide temperature range. The thermal expansion coefficient values were also calculated from the acquired experimental density values. From the experimental data, it was found that the density, viscosity, and refractive index decreased while conductivity increased with the increase of temperature. The correlation results were proposed to be in good agreement with the experimental data, and optimal fitting parameters were presented. In addition, the coefficient of thermal expansion was considered to be independent of temperature in the range of (298.15 to 353.15) K.
• OPTICAL INFORMATION RECORDING MEDIUM AND NEAR-INFRARED ABSORBING MATERIAL USED THEREIN
  申请人：Ricoh Company, Ltd

  公开号：EP0676299B1

  公开（公告）日：1998-12-30