(R)-methyl 2,2-dibutylthiazolidine-4-carboxylate | 920758-06-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-methyl 2,2-dibutylthiazolidine-4-carboxylate
• 英文别名: methyl (4R)-2,2-dibutyl-1,3-thiazolidine-4-carboxylate
• CAS: 920758-06-1
• 化学式: C₁₃H₂₅NO₂S
• 分子量: 259.413
• InChiKey: MVEIONHRJHOZCO-NSHDSACASA-N

物化性质

• 沸点：
  346.1±37.0 °C(Predicted)
• 密度：
  0.992±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-壬酮 、 D-半胱氨酸甲酯盐酸盐 在 对甲苯磺酸 作用下， 以 苯 为溶剂， 反应 48.0h， 以87%的产率得到(R)-methyl 2,2-dibutylthiazolidine-4-carboxylate
  参考文献：
  名称：

  Modular chiral thiazolidine catalysts in asymmetric aryl transfer reactions

  摘要：

  Modular chiral thiazolidine derivatives were synthesized in a single step from inexpensive and commercially available starting materials. These ligands catalyzed enantioselective arylation of different aldehydes using aryl boronic acids as a source of transferable aryl groups. The products were obtained in excellent yields and good enantioselectivities. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.10.025

文献信息

• Modular chiral thiazolidine catalysts in asymmetric aryl transfer reactions
  作者：Antonio Luiz Braga、Priscila Milani、Fabrício Vargas、Márcio W. Paixão、Jasquer A. Sehnem

  DOI：10.1016/j.tetasy.2006.10.025

  日期：2006.10

  Modular chiral thiazolidine derivatives were synthesized in a single step from inexpensive and commercially available starting materials. These ligands catalyzed enantioselective arylation of different aldehydes using aryl boronic acids as a source of transferable aryl groups. The products were obtained in excellent yields and good enantioselectivities. (c) 2006 Elsevier Ltd. All rights reserved.