N-propyl-L-Ser | 90600-11-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-propyl-L-Ser
• 英文别名: N-n-propyl-L-serine；Propylserine；(2S)-3-hydroxy-2-(propylamino)propanoic acid
• CAS: 90600-11-6
• 化学式: C₆H₁₃NO₃
• 分子量: 147.174
• InChiKey: CUFVMBQKFLNIQA-YFKPBYRVSA-N

物化性质

• 沸点：
  314.6±32.0 °C(Predicted)
• 密度：
  1.141±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  L-丝氨酸 、 丙醛 在 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 反应 18.0h， 以60%的产率得到N-propyl-L-Ser
  参考文献：
  名称：

  AN EFFICIENT ONE-STEP REDUCTIVEN-MONOALKYLATION OF α-AMINO ACIDS

  摘要：

  在氰基硼氢化钠存在下，无保护的 a-氨基酸与醛或酮发生反应，得到无机盐形式的 N-单烷基化氨基酸。此外，还介绍了该方法在合成具有重要生物价值的氨基酸的 N-烷基衍生物中的应用。

  DOI：

  10.1246/cl.1984.441

文献信息

• PARAKERATOSIS INHIBITOR, PORE-SHRINKING AGENT OR AGENT FOR PREVENTING/AMELIORATING ROUGH SKIN AND EXTERNAL COMPOSITION FOR SKIN
  申请人：Shiseido Company, Limited

  公开号：EP1884230A1

  公开（公告）日：2008-02-06

  The invention provides a parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/amaliorating agent that has a function such as parakeratosis inhibition, pore shrinkage, or rough skin -inhibition/abatement, poses no safety problems such as sensory irritation, and is very safe, and to further provide an external composition for skin to which a compound having the above-mentioned function has been added. The parakeratosis inhibitor agent, pore-shrinking agent, or rough skin preventing/amaliorating agent comprises one, two, or more compounds selected from the group consisting of α-amino acid derivatives and salts thereof. The external composition for skin comprises the one, two, or more compounds selected from the group consisting of α-amino acid derivatives and salts thereof as the above-mentioned parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/amaliorating agent.

  该发明提供了一种具有角化不全抑制、收缩毛孔或防止/改善粗糙皮肤功能的抑制剂、收缩毛孔剂或防止/改善粗糙皮肤剂，不会引起感觉刺激等安全问题，非常安全，并进一步提供了一种外用皮肤组合物，其中添加了具有上述功能的化合物。角化不全抑制剂、收缩毛孔剂或防止/改善粗糙皮肤剂包括从α-氨基酸衍生物和其盐组成的群中选择的一种、两种或更多化合物。外用皮肤组合物包括从α-氨基酸衍生物和其盐组成的群中选择的一种、两种或更多化合物，作为上述角化不全抑制剂、收缩毛孔剂或防止/改善粗糙皮肤剂。
• Beta-substituted non-canonical amino acids
  申请人：California Institute of Technology

  公开号：US10612056B2

  公开（公告）日：2020-04-07

  The present disclosure provides methods for preparing β-substituted tryptophan compounds. The methods include: combining i) an unsubstituted indole or a substituted indole, ii) a β-substituted serine, and iii) a tryptophan synthase β-subunit (i.e., a TrpB); and maintaining the resulting mixture under conditions sufficient to form the β-substituted tryptophan. The TrpB contains at least one amino acid mutation which promotes formation of an amino-acrylate intermediate. New TrpB variants and new β-substituted tryptophan analogs are also described.

  本公开提供了制备β-取代色氨酸化合物的方法。这些方法包括：将 i) 未取代的吲哚或取代的吲哚、ii) β-取代的丝氨酸和 iii) 色氨酸合成酶 β-亚基（即 TrpB）结合在一起；并将所得混合物保持在足以形成 β-取代的色氨酸的条件下。TrpB 至少含有一个氨基酸突变，可促进氨基丙烯酸酯中间体的形成。此外，还介绍了新的 TrpB 变体和新的β-取代色氨酸类似物。
• Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof
  申请人：GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

  公开号：US11078192B2

  公开（公告）日：2021-08-03

  Disclosed are an aromatic acetylene or aromatic ethylene compound, an intermediate, a preparation method, a pharmaceutical composition and a use thereof. The aromatic acetylene or aromatic ethylene compound has a significant inhibitory effect on PD-1 and PD-L1, and can effectively relieve or treat cancers and other related diseases.

  本发明公开了一种芳香族乙炔或芳香族乙烯化合物、一种中间体、一种制备方法、一种药物组合物及其用途。芳香炔或芳香乙烯化合物对 PD-1 和 PD-L1 有显著的抑制作用，能有效缓解或治疗癌症及其他相关疾病。
• METAL-POLISHING COMPOSITION AND CHEMICAL MECHANICAL POLISHING METHOD BY USING THE SAME
  申请人：KATO Tomoo

  公开号：US20080188079A1

  公开（公告）日：2008-08-07

  The present invention provides a metal-polishing composition for use in chemical mechanical polishing of semiconductor devices, comprising: (a) a compound represented by the following Formula A, (b) a compound represented by the following Formula B, (c) an abrasive grain, and (d) an oxidizing agent: in Formula A, R 1 represents an alkyl group having 1 to 3 carbon atoms; and R 2 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, and in Formula B, R 3 , R 4 , and R 5 each independently represent a hydrogen atom, or an alkyl, aryl, alkoxy, amino, aminoalkyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl or carbamoyl group.
• METHODS AND ENZYME CATALYSTS FOR THE SYNTHESIS OF NON-CANONICAL AMINO ACIDS
  申请人：California Institute of Technology

  公开号：US20180327793A1

  公开（公告）日：2018-11-15

  The present disclosure provides methods for preparing β-substituted tryptophan compounds. The methods include: combining i) an unsubstituted indole or a substituted indole, ii) a β-substituted serine, and iii) a tryptophan synthase β-subunit (i.e., a TrpB); and maintaining the resulting mixture under conditions sufficient to form the β-substituted tryptophan. The TrpB contains at least one amino acid mutation which promotes formation of an amino-acrylate intermediate. New TrpB variants and new β-substituted tryptophan analogs are also described.