| 1217266-98-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• CAS: 1217266-98-2
• 化学式: C₆₉H₁₇NO₂
• 分子量: 891.899
• InChiKey: LPYSEYZUYCVDON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.1
• 重原子数：
  72
• 可旋转键数：
  5
• 环数：
  33.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以100%的产率得到
  参考文献：
  名称：

  Synthesis and Characterization of Highly Water-Soluble Dendrofulleropyrrolidine Bisadducts with DNA Binding Activity

  摘要：

  The synthesis, characterization and DNA binding studies of a series of polycationic fullerene adducts are reported. Thew cationic species, exhibiting reasonably high water solubility and a heterogeneous distribution of positive charges, can efficiently complex plasmid DNA. Electrophoresis studies show different DNA binding efficiencies for different adducts, some of which can be considered excellent candidates for DNA binding therapies.

  DOI：

  10.1021/ol301946r
• 作为产物：
  描述：

  聚合甲醛 、 足球烯 、 2-((3-(tert-butoxy)-3-oxopropyl)amino)acetic acid 以 邻二氯苯 为溶剂， 反应 0.75h， 以45%的产率得到
  参考文献：
  名称：

  Synthesis and Characterization of Highly Water-Soluble Dendrofulleropyrrolidine Bisadducts with DNA Binding Activity

  摘要：

  The synthesis, characterization and DNA binding studies of a series of polycationic fullerene adducts are reported. Thew cationic species, exhibiting reasonably high water solubility and a heterogeneous distribution of positive charges, can efficiently complex plasmid DNA. Electrophoresis studies show different DNA binding efficiencies for different adducts, some of which can be considered excellent candidates for DNA binding therapies.

  DOI：

  10.1021/ol301946r

文献信息

• Synthesis and Characterization of Highly Water-Soluble Dendrofulleropyrrolidine Bisadducts with DNA Binding Activity
  作者：Alejandro Montellano López、Francesco Scarel、Noelia Rubio Carrero、Ester Vázquez、Aurelio Mateo-Alonso、Tatiana Da Ros、Maurizio Prato

  DOI：10.1021/ol301946r

  日期：2012.9.7

  The synthesis, characterization and DNA binding studies of a series of polycationic fullerene adducts are reported. Thew cationic species, exhibiting reasonably high water solubility and a heterogeneous distribution of positive charges, can efficiently complex plasmid DNA. Electrophoresis studies show different DNA binding efficiencies for different adducts, some of which can be considered excellent candidates for DNA binding therapies.