3-(3-cyano-4-hydroxyphenyl)-L-alanine | 96844-03-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(3-cyano-4-hydroxyphenyl)-L-alanine
• 英文别名: 3-cyano-L-tyrosine；(2S)-2-amino-3-(3-cyano-4-hydroxyphenyl)propanoic acid
• CAS: 96844-03-0
• 化学式: C₁₀H₁₀N₂O₃
• 分子量: 206.201
• InChiKey: UGAKFUKRKDNFOB-QMMMGPOBSA-N

物化性质

• 沸点：
  447.1±45.0 °C(Predicted)
• 密度：
  1.41±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-(3-cyano-4-hydroxyphenyl)-L-alanine 在 盐酸 、 水 作用下， 生成 3-(3-carboxy-4-hydroxyphenyl)-L-alanine hydrochloride
  参考文献：
  名称：

  Arnold, Zdzislaw S., Polish Journal of Chemistry, 1984, vol. 58, # 1-3, p. 157 - 161

  摘要：

  DOI：
• 作为产物：
  描述：

  N-acetyl-3-(3-cyano-4-hydroxyphenyl)-L-alanine ethyl ester 在 盐酸 作用下， 反应 2.0h， 以93%的产率得到3-(3-cyano-4-hydroxyphenyl)-L-alanine
  参考文献：
  名称：

  Arnold, Zdzislaw S., Polish Journal of Chemistry, 1984, vol. 58, # 1-3, p. 157 - 161

  摘要：

  DOI：

文献信息

• Nucleic acids encoding mutant human carboxypeptidase A enzymes
  申请人：Glaxo Wellcome, Inc.

  公开号：US06319702B1

  公开（公告）日：2001-11-20

  The present invention relates to nucleic acid molecules encoding mutant human carboxypeptidase A enzymes, and encoding conjugates of targeting molecules and mutant human carboxypeptidase A enzymes. The invention further relates to vectors and cell lines containing such nucleic acid molecules.

  本发明涉及编码突变人类羧肽酶A酶的核酸分子，以及编码靶向分子和突变人类羧肽酶A酶的共轭体的核酸分子。本发明还涉及包含这种核酸分子的载体和细胞系。
• Cell-targeting molecule comprising a mutant human carboxypeptidase A
  申请人：Glaxo Wellcome Inc.

  公开号：US06140100A1

  公开（公告）日：2000-10-31

  Conjugates of a cell targetting molecule and a mutant human carboxypeptidase A enzyme are provided. Suitable targetting molecules include antibodies, hormones, ligands, cytokines, antigens, oligonucleotides and peptidomimetics. Enzymes comprising a mutant human carboxypeptidase A enzyme are also provided.

  提供了细胞靶向分子和突变人类羧肽酶A酶的共轭。适当的靶向分子包括抗体、激素、配体、细胞因子、抗原、寡核苷酸和肽类类似物。还提供了包含突变人类羧肽酶A酶的酶。
• New enzymes and prodrugs for ADEPT
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0728018B1

  公开（公告）日：2003-08-06
• THERAPY
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0728018A1

  公开（公告）日：1996-08-28
• Receptor-binding cyclic peptides and methods of use
  申请人：Sutcliffe-Goulden Julie

  公开号：US20060029544A1

  公开（公告）日：2006-02-09

  The present invention provides novel receptor-binding cyclic peptides that advantageously display high receptor binding affinity and selectively. More particularly, the present invention provides integrin-binding cyclic peptides containing an integrin-binding motif such as an RGD motif, an aromatic amino acid such as a tyrosine residue, and a lysine residue having a pi-pi stacking moiety conjugated to its ε-amino group. Methods for identifying receptor-binding cyclic peptides and for using the cyclic peptides of the present invention for imaging a tumor, organ, or tissue and for treating cancer, inflammatory diseases, and autoimmune diseases are also provided.