2-amino-6-chloropurine sodium salt | 131853-16-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-amino-6-chloropurine sodium salt
• 英文别名: sodium;6-chloro-9H-purin-3-id-2-imine
• CAS: 131853-16-2
• 化学式: C₅H₃ClN₅*Na
• 分子量: 191.555
• InChiKey: PPCZDQKXCBNKGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.78
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  65.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-amino-6-chloropurine sodium salt 在 copper(l) iodide 盐酸 、 二碘甲烷 、 碘 、 亚硝酸异戊酯 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 2.25h， 生成 2-chloro-9-(2,3-dihydroxypropyl)-6-iodo-9H-purine
  参考文献：
  名称：

  New 2-Alkynyl Derivatives of the Acyclic Nucleoside 9-(2,3-Dihydroxypropyl)adenine and Their 6-Guanidinopurine Counterparts as Potential Effectors of Adenosine Receptors

  摘要：

  一系列新的2-炔基衍生物，包括无环核苷酸9-(2,3-二羟基丙基)-腺嘌呤和它们的6-胍胺基嘌呤类似物，通过Sonogashira偶联法制备。对制备的化合物对A₁和A_2A受体的影响进行了研究。

  DOI：

  10.1135/cccc20032201
• 作为产物：
  描述：

  2-氨基-6-氯嘌呤 在 sodium methylate 作用下， 以 甲醇 、 乙醚 为溶剂， 以93 g (82%)的产率得到2-amino-6-chloropurine sodium salt
  参考文献：
  名称：

  Synthesis of a 3,4-dihydroxy-1-cyclopentanylpurinone

  摘要：

  从公式(IV)的醇出发，通过保护和氰化反应制备出公式(I)的三元醇。反应步骤包括保护醇基，氰化生成氰基，双键异构化，水解还原氰基回到醇基，以及顺式双羟基化双键。

  公开号：

  US05329008A1

文献信息

• Kim, Choung Un; Misco, Peter F.; Luh, Bing Y., Heterocycles, 1990, vol. 31, # 9, p. 1571 - 1574
  作者：Kim, Choung Un、Misco, Peter F.、Luh, Bing Y.、Martin, John C.

  DOI：——

  日期：——
• Synthesis of Acyclonucleoside Phosphonates as Antiviral Agents Against Cytomegalovirus
  作者：Elmer J. Reist、Wallace W. Bradford、Beatrice L. Ruhland-Fritsch、Priscilla A. Sturm、Nurulain T. Zaveri、John Huffman、Robert W. Sidwell

  DOI：10.1080/15257779408013261

  日期：1994.3

  Phosphonic acid analogs of ACV and DHPG that are isosteric with ACV phosphate and DHPG phosphate have been synthesized and evaluated for antiviral activity against human, murine. and guinea pig strains of cytomegalovirus. The phosphonates showed high activity against all of the strains. They were also evaluated against a DHPG resistant strain of human cytomegalovirus. Although the activity dropped considerably, significant antiviral activity was still evident.
• .pi.-Allylpalladium Formation from Allylic Amines via N,N-Ditosylimides and N-Tosylamides: Efficient Synthesis of the Antiviral Agent Carbovir
  作者：Michael E. Jung、Hakjune Rhee

  DOI：10.1021/jo00096a006

  日期：1994.8

  Allylic amines can be easily converted into their N,N-ditosylimides or N-tosylamides which are sufficiently good leaving groups to afford pi-allylpalladium complexes and, hence, with nucleophiles, new allylic systems with retention of configuration. The synthetic utility of this process has been demonstrated by an efficient synthesis of the antiviral agent (+/-)-carbovir,(1) from cyclopentadiene in only seven steps and 13% overall yield.
• Acyclic Nucleotide Analogues and Related Compounds
  作者：Antonín Holý、Hana Dvoráková

  DOI：10.1080/15257779508012452

  日期：1995.5.1

  Acyclic nucleotide analogues bearing amino- and N-substituted amino groups in the side chain were prepared by alkylation of the bases with corresponding oxiranes and subsequent introduction of phosphonomethyl ether function. Novel enantiomeric synthons for the preparation of HPMP-compounds were prepared from a common intermediate and applied to syntheses of novel compounds (e.g. 8-azaguanine derivatives).
• KIM, CHOUNG UN;MISCO, PETER F.;MARTIN, JOHN C., NUCLEOSIDES AND NUCLEOTIDES, 9,(1990) N, C. 579-585
  作者：KIM, CHOUNG UN、MISCO, PETER F.、MARTIN, JOHN C.

  DOI：——

  日期：——