dibutyl trithiocarbonate | 1608-91-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫基化合物
• 英文名称: dibutyl trithiocarbonate
• 英文别名: di(n-butyl) trithiocarbonate；trithiocarbonic acid dibutyl ester；Trithiokohlensaeure-dibutylester；Dibutyl-trithiocarbonat；Bis(butylsulfanyl)methanethione
• CAS: 1608-91-9
• 化学式: C₉H₁₈S₃
• 分子量: 222.44
• InChiKey: MTSWLHARLQHYMU-UHFFFAOYSA-N

物化性质

• 沸点：
  125-127 °C(Press: 4 Torr)
• 密度：
  1.059±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  82.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  dibutyl trithiocarbonate 在 乙醇 、 一水合肼 作用下， 生成 N,N'-bis-thiohydrazinocarbonyl-hydrazine
  参考文献：
  名称：

  The Effects of a Collaborative Model of Primary Care on the Mortality and Hospital Use of Community-Dwelling Older Adults

  摘要：

  Background. This study evaluates the ability of a model of collaborative primary care practice to reduce mortality and hospital use in community-dwelling elderly persons.Methods. Pour rural and four urban clinic sites in east central Illinois were randomized to form treatment and comparison clinics from which patients were enrolled and followed prospectively for 2 years. Patients from the practices of participating physicians were eligible if they were aged 65 and older. were living in the community, and had at least one risk factor as determined prior to the study. Medicare hospital data were obtained from the Health Care Financing Administration. Demographic and health status measures were obtained by telephone interview every IZ months throughout the study.Results. The treatment group experienced a 49% reduction in all-cause mortality during the second year of the study (odds ratio. 0.51, 95% confidence interval. 0.29-0.91, p = .02). There were no significant differences between treatment and comparison patients in percentage of persons hospitalized, hospital length of stay, or Medicare payments. Although measures of health status indicated that the treatment group was significantly sicker at baseline at the end of 1 year, these differences disappeared by the end of 2 years.Conclusions. The collaborative primary care model evaluated in this study significantly reduced mortality in the second year, without increasing hospital use. These findings suggest that a collaborative primary core team that enhances primary care practice can result in better patient outcomes.

  DOI：

  10.1093/gerona/56.2.m106
• 作为产物：
  描述：

  对甲苯磺酸正丁酯 在 二硫化碳 、 caesium carbonate 作用下， 以 二甲基亚砜 为溶剂， 反应 3.0h， 以99%的产率得到dibutyl trithiocarbonate
  参考文献：
  名称：

  An efficient, one-pot synthesis of trithiocarbonates from alcoholic tosylates using the Cs2CO3/CS2 system

  摘要：

  A single-step novel protocol for the preparation of symmetrical trithiocarbonates from a corresponding variety of primary, secondary, and tertiary alcoholic tosylates using the Cs2CO3/CS2 system, was developed. This protocol is mild and more efficient than the reported methods.

  DOI：

  10.1007/s00706-008-0956-7

文献信息

• Generation of 1,2-ethanebis(trithiocarbonic acid) dianion from 2,2′-[1,2-ethanediylbis(thio)]- bis-1,3-dithiolane and its reaction with alkyl halides
  作者：Shigeo Tanimoto、Tatuo Oida、Kouhel Hatanaka、Toyonari Sugimoto

  DOI：10.1016/s0040-4039(01)92515-8

  日期：1981.1

  Generation of 1,2-ethanbis(trithiocarbonic acid) dianion from 2,2′-[1,2-ethanediylbis (thio)]bis-1,3-dithiolane and its reaction with alkyl halldes were investigated.

  研究了由2,2'-[1,2-乙二基双（硫代）]双-1,3-二硫杂环戊烷生成1,2-乙双（三硫代碳酸）二价阴离子及其与烷基卤化物的反应。
• A convenient one-pot method for the synthesis of symmetrical dialkyl trithiocarbonates using NH₄ OAc under mild neutral conditions
  作者：Zeinab Arzehgar、Hosna Ahmadi

  DOI：10.1002/jccs.201800062

  日期：2019.3

  A facial, new, one‐pot method for the preparation of symmetrical organic trithiocarbonates from various alkyl halides and carbon disulfide is described. This is a convenient, clean, and mild procedure, which involves the use of the neutral, nontoxic, commercially available, and inexpensive reagent NH4OAc in the preparation of the trithiocarbonate ion from carbon disulfide.

  描述了一种用面部，新颖，一锅法从各种卤代烷和二硫化碳制备对称有机三硫代碳酸酯的方法。这是一种方便，清洁且温和的过程，涉及在从二硫化碳制备三硫代碳酸根离子时使用中性，无毒，可商购且廉价的试剂NH 4 OAc。
• The Thermal and Mass Spectral Fragmentation of N-Butyl Thiolo-, Thiono-, and Dithio-Chloroformate
  作者：Harry R. Hudson、Andrew J. Koplick

  DOI：10.1080/10426507.2011.582801

  日期：2011.8.1

  chlorides (mainly without rearrangement) together with numerous other byproducts, indicating the operation of a more complex combination of reaction pathways. The mass spectra of all three thio compounds exhibit molecular ions; the most prominent fragment ions in their spectra are the n-butyl cation, and the radical cations COS+ • and CS2 + •. Numerous chlorine-containing ions of low intensity are also observed

  摘要 硫代氯甲酸正丁酯在 150°C 的热分解遵循与先前报道的氯甲酸正丁酯相似的模式，得到氯甲酸丁酯，其大部分重排为仲丁基异构体。提出了一种涉及 1,2- 和 1,3- 氢化物位移的离子对机制。不太稳定的亚硫基和二硫代氯甲酸酯分解后产生的丁基氯（主要是没有重排）和许多其他副产物的收率较低，这表明反应途径的组合更为复杂。所有三种硫代化合物的质谱均显示分子离子；其光谱中最突出的碎片离子是正丁基阳离子，以及自由基阳离子 COS+ • 和 CS2 + •。还观察到了许多低强度的含氯离子，并讨论了它们的形成方式。
• Mild and Efficient One-Step Synthesis of Trithiocarbonates Using Minimum Amount of CS₂
  作者：Takeshi Endo、Naoto Aoyagi、Bungo Ochiai、Hideharu Mori

  DOI：10.1055/s-2006-932480

  日期：——

  Symmetrical dialkyl trithiocarbonates were obtained from various alkyl halides with an equivalent of carbon disulfide and cesium carbonate in polar aprotic solvents, although the conventional synthesis of trithiocarbonates had required large excess amount of carbon disulfide. This reaction proceeds under ambient conditions, for example, at room temperature under an aerial atmosphere, without strong

  尽管三硫代碳酸酯的常规合成需要大量过量的二硫化碳，但在极性非质子溶剂中，由各种烷基卤化物与等量的二硫化碳和碳酸铯得到对称的二烷基三硫代碳酸酯。该反应在环境条件下进行，例如在室温和大气气氛下，没有强碱和相转移催化剂。
• TBAH-Catalyzed One-Pot Synthesis of Symmetrical Trithiocarbonates from Alkyl Halides and Carbon Disulfide under Neat Aqueous Conditions
  作者：Mohammad Soleiman-Beigi、Zeinab Arzehgar、Barahman Movassagh

  DOI：10.1055/s-0029-1217132

  日期：2010.2

  tetra-n-butylammonium hydroxide catalyzed, one-pot protocol has been developed for the synthesis of symmetrical trithiocarbonates from alkyl halides and carbon disulfide­ under neat aqueous conditions. trithiocarbonate - tetra-n-butylammonium hydroxide - one-pot - neat - carbon disulfide

  已经开发了一种新颖且有效的四正丁基氢氧化铵催化的一锅操作规程，用于在纯水条件下由卤代烷和二硫化碳合成对称的三硫代碳酸酯。 三硫代碳酸盐-四正丁基氢氧化铵-一锅-纯净-二硫化碳