5-nitro-3-pyrazole-dPEG8carboxytyramide | 1354021-45-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-nitro-3-pyrazole-dPEG8carboxytyramide
• 英文别名: N-[2-[2-[2-[2-[2-[2-[2-[2-[3-[2-(4-hydroxyphenyl)ethylamino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]-5-nitro-1H-pyrazole-3-carboxamide
• CAS: 1354021-45-6
• 化学式: C₃₁H₄₉N₅O₁₃
• 分子量: 699.756
• InChiKey: RNTUZXNDIYHQMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  49
• 可旋转键数：
  31
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  227
• 氢给体数：
  4
• 氢受体数：
  14

反应信息

• 作为产物：
  描述：

  对羟基苯乙胺 、 (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[2-[2-[(5-nitro-1H-pyrazole-3-carbonyl)amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 以79%的产率得到5-nitro-3-pyrazole-dPEG8carboxytyramide
  参考文献：
  名称：

  [EN] HAPTEN CONJUGATES FOR TARGET DETECTION
  [FR] CONJUGUÉS D'HAPTÈNE POUR UNE DÉTECTION DE CIBLE

  摘要：

  公开号：

  WO2012003476A3

文献信息

• Signaling conjugates and methods of use
  申请人：Ventana Medical Systems, Inc.

  公开号：US10041950B2

  公开（公告）日：2018-08-07

  Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.

  本文公开了信号结合物的实施方案、使用信号结合物的方法的实施方案以及包含信号结合物的试剂盒的实施方案。 所公开的信号轭合物包括潜伏反应分子和发色分子，潜伏反应分子可进一步包括适于将潜伏反应分子与发色分子偶联的连接体。 信号共轭物可用于检测生物样本中的一个或多个靶标，并能直接共价沉积在靶标上或靶标附近。 所公开的信号轭合物使用方法的具体实施例包括复用方法。
• SIGNALING CONJUGATES AND METHODS OF USE
  申请人：VENTANA MEDICAL SYSTEMS, INC.

  公开号：US20130260379A1

  公开（公告）日：2013-10-03

  Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.
• [EN] DIGITALLY ENHANCED MICROSCOPY FOR MULTIPLEXED HISTOLOGY<br/>[FR] MICROSCOPIE AMÉLIORÉE NUMÉRIQUEMENT POUR HISTOLOGIE MULTIPLEXÉE
  申请人：VENTANA MED SYST INC

  公开号：WO2014143155A1

  公开（公告）日：2014-09-18

  A multispectral imaging system (100) for imaging a specimen located on a microscope slide (134) comprise: an imaging apparatus (112) including an illuminator (140) with a plurality of different color light sources (180a-d) for sequentially producing light for sequentially illuminating the specimen, an image capture device (120) for capturing a plurality of specimen images each corresponding to the specimen being exposed to light from a respective one of the light sources, and a processing device (122) configured to produce contrast enhanced color image data and/or spectrally deconvolved image data based on the captured specimen images; at least one lens positioned along an optical path extending from the specimen to the image capture device; and a display (114) in communication with the imaging apparatus and configured to display contrast enhanced output (144) and/or spectrally deconvolved output (144) of the specimen based on the contrast enhanced color image data and/or spectrally deconvolved image data from the processing device.
• [EN] HAPTEN CONJUGATES FOR TARGET DETECTION<br/>[FR] CONJUGUÉS D'HAPTÈNE POUR UNE DÉTECTION DE CIBLE
  申请人：VENTANA MED SYST INC

  公开号：WO2012003476A3

  公开（公告）日：2012-05-03