Propylene glycol monocaprate | 68795-69-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Propylene glycol monocaprate
• 英文别名: decanoic acid;propane-1,2-diol
• CAS: 68795-69-7
• 化学式: C13H28O4
• 分子量: 248.36
• InChiKey: PHMQYKDOTWAOBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.57
• 重原子数：
  17
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• FORMULATION FOR ENHANCED TRANSDERMAL ABSORPTION OF DRUG
  申请人：UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)

  公开号：US20190091168A1

  公开（公告）日：2019-03-28

  Provided is a transdermal formulation including a transdermal absorption enhancer including an aliphatic hydrocarbon derivative and a pyrrolidone derivative; and a benzene diamine derivative for preventing or treating dementia, Alzheimer's disease, and hair loss.

  提供的是一种透皮制剂，包括一种透皮吸收增强剂，其中包括一种脂肪族碳氢化合物衍生物和一种吡咯烷酮衍生物；以及一种苯二胺衍生物，用于预防或治疗痴呆症、阿尔茨海默病和脱发。
• Polyglycerols and production thereof
  申请人：Endo Toshio

  公开号：US20070049775A1

  公开（公告）日：2007-03-01

  A polyglycerol composition contains diglycerol, triglycerol, and tetraglycerol each in a content of 5 percent by weight or more, has a total content of diglycerol, triglycerol, and tetraglycerol of 75 percent by weight or more, has a total content of higher polyglycerol components of 10 percent by weight or less, the higher polyglycerol components each having a degree of polymerization of 7 or higher, and is substantially free from chlorine atom. A process prepares a polyglycerol composition by reacting glycerol and/or a polyglycerol with glycidol in the presence of an activated carbon catalyst.

  一种聚甘油组合物，其中二甘油、三甘油和四甘油的含量均达到重量的5％或更多，其二甘油、三甘油和四甘油的总含量达到重量的75％或更多，高聚甘油成分的总含量不超过重量的10％，高聚甘油成分的聚合度均达到7或更高，并且基本上不含氯原子。一种方法通过在活性炭催化剂存在下将甘油和/或聚甘油与环氧丙烷反应来制备聚甘油组合物。
• Dermal anti-inflammatory composition
  申请人：——

  公开号：US20020165286A1

  公开（公告）日：2002-11-07

  A pharmaceutical composition for dermal application comprises a lipophilic anti-inflammatory compound and a pharmaceutically acceptable vehicle comprising a lipophilic excipient capable of solubilizing the anti-inflammatory compound and targeting said compound to the pilosebaceous ducts on application of the composition on the skin. The composition may be used in the treatment of dermal inflammatory conditions, in particular acne.

  一种用于皮肤应用的制剂，包括一个亲脂性抗炎化合物和一种药学上可接受的载体，该载体包括一种亲脂性赋形剂，能够溶解抗炎化合物并将该化合物靶向应用于皮肤上的毛囊皮脂导管。该制剂可用于治疗皮肤炎症状况，特别是痤疮。
• EXTERNAL PREPARATION CONTAINING CYCLOSPORIN
  申请人：LTT INSTITUTE CO., LTD.

  公开号：EP0547229A1

  公开（公告）日：1993-06-23

  An external preparation containing cyclosporin as the active ingredient, characterized by comprising (a) cyclosporin, (b) an organic solvent for dissolving the same, (c) a fatty acid ester of a monohydric alcohol, which is liquid at 25 °C and bears at least 8 carbon atoms in total, and/or an alkanolamine which is liquid at 25 °C, (d) an oleaginous substance which is solid at 25 °C, and (e) a surfactant, wherein the cyclosporin content ranges from 0.1 to 10 wt.% and the content of the ester and/or alkanolamine ranges from 1 to 15 wt.%. The preparation has an excellent efficacy of curing atopic dermatitis, psoriasis, allergic contact dermatitis, and so forth.

  一种含有环孢素作为有效成分的外用制剂，其特征在于包括：(a) 环孢素，(b) 用于溶解环孢素的有机溶剂，(c) 一元醇的脂肪酸酯，该脂肪酸酯在 25 °C时为液态，总共含有至少 8 个碳原子，和/或烷醇胺，该烷醇胺在 25 °C时为液态，(d) 含油物质，该含油物质在 25 °C时为固态，和 (e) 表面活性剂，其中环孢素的含量范围为 0.1 至 10 重量%，酯和/或烷醇胺的含量为 1 至 15 重量%。该制剂在治疗特应性皮炎、牛皮癣、过敏性接触性皮炎等方面具有极佳的疗效。
• COMPOSITION OF EXTERNAL PREPARATION
  申请人：TSUMURA & CO.

  公开号：EP0788794A1

  公开（公告）日：1997-08-13

  Disclosed herein is an external preparation composition, such as a liquid preparation, cream, ointment or cataplasm plaster, characterized in that the composition contains a water-soluble salt of diclofenac such as diclofenac sodium, water, and a fatty acid dialkylolamide and/or its polyoxyethylene adduct. The external preparation composition according to this invention is excellent in the percutaneous absorption of the water-soluble salt of diclofenac, which has high solubility and stability in the preparation.

  本发明公开了一种外用制剂组合物，如液体制剂、乳膏、软膏或卡他性膏药，其特征在于该组合物含有双氯芬酸的水溶性盐（如双氯芬酸钠）、水和脂肪酸二烷基酰胺和/或其聚氧乙烯加合物。 根据本发明的外用制剂组合物在经皮吸收双氯芬酸的水溶性盐方面表现出色，其在制剂中具有高溶解度和稳定性。