Alanine trimethylsilyl ester hydrochloride | 130529-58-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Alanine trimethylsilyl ester hydrochloride
• 英文别名: trimethylsilyl (2S)-2-aminopropanoate;hydrochloride
• CAS: 130529-58-7
• 化学式: C₆H₁₅NO₂Si*ClH
• 分子量: 197.737
• InChiKey: KDLHLRUDSOESHW-JEDNCBNOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.13
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  52.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  9-溴-9-苯基芴 、 Alanine trimethylsilyl ester hydrochloride 在 甲醇 、 lead(II) nitrate 、 三乙胺 作用下， 生成 (2S)-N-(9-phenylfluoren-9-yl)alanine
  参考文献：
  名称：

  N-保护的α-氨基醛的构型稳定性

  摘要：

  合成这些 en 3 etapes de [phenyl-9 fluorenyl-9amino]-2 propanal a partir de l'alanine protegee通信者。Purete optique de cet 氨基醛

  DOI：

  10.1021/ja00235a035
• 作为产物：
  描述：

  三甲基氯硅烷 、 L-丙氨酸 以 氯仿 、 乙腈 为溶剂， 反应 2.0h， 生成 Alanine trimethylsilyl ester hydrochloride
  参考文献：
  名称：

  N-保护的α-氨基醛的构型稳定性

  摘要：

  合成这些 en 3 etapes de [phenyl-9 fluorenyl-9amino]-2 propanal a partir de l'alanine protegee通信者。Purete optique de cet 氨基醛

  DOI：

  10.1021/ja00235a035

文献信息

• Parental administration of pyruyate precursors
  申请人：Abbott Laboratories

  公开号：US05472980A1

  公开（公告）日：1995-12-05

  A method for administering pyruvate is disclosed which comprises administering a therapeutically effective amount of a pyruvate precursor to a mammal in the form of pyruvamide or a pyruvyl-amino acid. The pyruvyl-amino acid is preferably selected from the group comprising pyruvyl-glycine, pyruvyl-alanine, pyruvyl-leucine, pyruvyl-valine, pyruvyl-isoleucine, pyruvyl-phenylalanine, pyruvyl-proline and pyruvyl-sarcosine, and their amides and esters as well as their salts. Associated with the administration of a pyruvate precursor to a mammal in accordance with this invention are improved insulin resistance, lower fasting insulin levels, and reduced fat gain. Novel methods of synthesizing several pyruvate precursors are also disclosed.

  本发明公开了一种给予丙酮酸的方法，其中包括以丙酮酰胺或丙酰氨基酸的形式给哺乳动物以丙酮酸前体的治疗有效剂量。丙酰氨基酸优选从以下组中选择：丙酰基甘氨酸，丙酰基丙氨酸，丙酰基亮氨酸，丙酰基缬氨酸，丙酰基异亮氨酸，丙酰基苯丙氨酸，丙酰基脯氨酸和丙酰基肌氨酸及其酰胺和酯以及其盐。根据本发明给予哺乳动物丙酮酸前体的方法与改善胰岛素抵抗、降低空腹胰岛素水平和减少脂肪增加有关。本发明还公开了合成几种丙酮酸前体的新方法。
• Method of administering pyruvate and methods of synthesizing pyruvate
  申请人：Abbott Laboratories

  公开号：US05256697A1

  公开（公告）日：1993-10-26

  A method for administering pyruvate is disclosed which comprises administering a therapeutically effective amount of a pyruvate precursor to a mammal in the form of pyruvamide or a pyruvyl-amino acid. The pyruvyl-amino acid is preferably selected from the group comprising pyruvyl-glycine, pyruvyl-alanine, pyruvyl-leucine, pyruvyl-valine, pyruvyl-isoleucine, pyruvyl-phenylalanine, pyruvyl-proline and pyruvyl-sarcosine, and their amides and esters as well as their salts. Associated with the administration of a pyruvate precursor to a mammal in accordance with this invention are improved insulin resistance, lower fasting insulin levels, and reduced fat gain. Novel methods of synthesizing several pyruvate precursors are also disclosed.

  本发明揭示了一种给予丙酮酸的方法，其包括以丙酮酰胺或丙酰氨基酸的形式向哺乳动物给予丙酮酸前体的治疗有效量。所述丙酰氨基酸优选从包括丙酰甘氨酸、丙酰丙氨酸、丙酰亮氨酸、丙酰缬氨酸、丙酰异亮氨酸、丙酰苯丙氨酸、丙酰脯氨酸和丙酰肌氨酸及其酰胺和酯以及其盐的群体中选择。根据本发明向哺乳动物给予丙酮酸前体的治疗，可改善胰岛素抵抗、降低空腹胰岛素水平和减少脂肪增加。本发明还揭示了合成几种丙酮酸前体的新方法。
• Method for reducing insulin resistance in mammals
  申请人：Abbott Laboratories

  公开号：US05283260A1

  公开（公告）日：1994-02-01

  A method for administering pyruvate is disclosed which comprises administering a therapeutically effective amount of a pyruvate precursor to a mammal in the form of pyruvamide or a pyruvyl-amino acid. The pyruvyl-amino acid is preferably selected from the group comprising pyruvyl-glycine, pyruvyl-alanine, pyruvyl-leucine, pyruvyl-valine, pyruvyl-isoleucine, pyruvylphenyl al anine, pyruvyl-proline and pyruvyl-sarcosine, and their amides and esters as well as their salts. Associated with the administration of a pyruvate precursor to a mammal in accordance with this invention are improved insulin resistance, lower fasting insulin levels, and reduced fat gain. Novel methods of synthesizing several pyruvate precursors are also disclosed.

  本发明公开了一种给予丙酮酸的方法，包括给哺乳动物以丙酮酸前体的治疗有效量，其形式为丙酰胺或丙酰基-氨基酸。所述丙酰基-氨基酸优选从以下群组中选择：丙酰基-甘氨酸、丙酰基-丙氨酸、丙酰基-亮氨酸、丙酰基-缬氨酸、丙酰基-异亮氨酸、丙酰基-苯丙氨酸、丙酰基-脯氨酸和丙酰基-肌氨酸及其酰胺和酯以及其盐。根据本发明给予哺乳动物丙酮酸前体的方法与改善胰岛素抵抗、降低空腹胰岛素水平和减少脂肪增加有关。本发明还公开了合成几种丙酮酸前体的新方法。
• Method of synthesizing the precursor pyruvamide
  申请人：Abbott Laboratories

  公开号：US05312985A1

  公开（公告）日：1994-05-17

  A method for administering pyruvate is disclosed which comprises administering a therapeutically effective amount of a pyruvate precursor to a mammal in the form of pyruvamide or a pyruvyl-amino acid. The pyruvyl-amino acid is preferably selected from the group comprising pyruvyl-glycine, pyruvyl-alanine, pyruvyl-leucine, pyruvyl-valine, pyruvyl-isoleucine, pyruvyl-phenylalanine, pyruvyl-proline and pyruvyl-sarcosine, and their amides and esters as well as their salts. Associated with the administration of a pyruvate precursor to a mammal in accordance with this invention are improved insulin resistance, lower fasting insulin levels, and reduced fat gain. Novel methods of synthesizing several pyruvate precursors are also disclosed.

  本发明公开了一种给予丙酮酸的方法，其中包括以丙酮酰胺或丙酰氨基酸的形式向哺乳动物给予丙酮酸前体的治疗有效量。丙酰氨基酸优选从包括丙酰甘氨酸、丙酰丙氨酸、丙酰亮氨酸、丙酰缬氨酸、丙酰异亮氨酸、丙酰苯丙氨酸、丙酰脯氨酸和丙酰肌氨酸及其酰胺和酯以及盐的群组中选择。根据本发明向哺乳动物给予丙酮酸前体伴随着改善胰岛素抵抗、降低空腹胰岛素水平和减少脂肪增加。本发明还公开了合成几种丙酮酸前体的新方法。